{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T13:27:11Z","timestamp":1793626031328,"version":"4.5.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Diabetes mellitus (DM) is a chronic metabolic disorder characterized by insulin resistance, impaired insulin secretion, and increased cardiometabolic and inflammatory burden. Zinc plays a key biological role in insulin synthesis, storage, signalling and antioxidant defence; however, the clinical relevance and consistency of zinc supplementation effects in diabetes remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed\/MEDLINE, Web of Science, Scopus, CINAHL and Google Scholar was conducted to identify randomized controlled trials (RCTs) assessing zinc supplementation in individuals with diabetes, gestational diabetes or prediabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen RCTs involving 1023 participants met the eligibility criteria. Zinc supplementation significantly increased plasma zinc concentrations (MD\u2009=\u20097.80; 95% CI 4.33 to 11.26) and improved insulin resistance, as reflected by reductions in serum insulin (MD\u2009=\u2009\u22122.50; 95% CI \u22124.69 to \u22120.31) and HOMA\u2010IR (MD\u2009=\u2009\u22121.10; 95% CI \u22122.05 to \u22120.15). Total cholesterol decreased modestly but significantly (MD\u2009=\u2009\u22125.70; 95% CI \u22127.50 to \u22123.89), representing a relatively small absolute reduction, while LDL cholesterol showed a modest increase (MD\u2009=\u20093.46; 95% CI 1.48 to 5.43), although the clinical relevance of this finding remains uncertain. Inflammatory and oxidative stress markers improved, including reductions in C\u2010reactive protein (SMD\u2009=\u2009\u22120.91; 95% CI \u22121.43 to \u22120.38) and malondialdehyde (SMD\u2009=\u2009\u22120.76; 95% CI \u22121.34 to \u22120.18), alongside an increase in total antioxidant capacity (SMD\u2009=\u20091.79; 95% CI 0.68 to 2.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Zinc supplementation was associated with improvements in insulin resistance, inflammatory status and oxidative stress markers in individuals with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>International Prospective Register of Systematic Reviews (PROSPERO) registration number: CRD42025638646<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70264","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:10:25Z","timestamp":1786651825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"9","author":[{"given":"Jessica Paola","family":"Loaiza\u2010Giraldo","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Central del Valle del Cauca (UCEVA)  Tulu\u00e1 Valle del Cauca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Amigo\u2010Fierro","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda, Facultad de Medicina Universidad Andr\u00e9s Bello  Santiago 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