{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:12:08Z","timestamp":1787901128064,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>While dipeptidyl peptidase\u20104 (DPP\u20104) inhibitors are commonly considered to have a class effect, emerging evidence suggests intra\u2010class heterogeneity in pharmacological properties. For patients who fail to achieve target glycemic levels with initial DPP\u20104 inhibitors therapy, intra\u2010class therapeutic interchange may offer an alternative to dose escalation or add\u2010on therapy. This study evaluated the effectiveness of evogliptin, a novel and potent DPP\u20104 inhibitor with a unique binding structure, as a strategy for therapeutic optimization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This follow\u2010up analysis included patients with HbA1c \u2265\u20097.0% who had received metformin plus a DPP\u20104 inhibitor other than evogliptin for at least 12\u2009weeks and were subsequently switched to evogliptin. Changes in HbA1c and target achievement at 12 and 24\u2009weeks were assessed according to the initial DPP\u20104 inhibitors. Multivariable linear regression was performed to identify independent predictors of HbA1c reduction. Additional exploratory subgroup analyses were conducted according to demographic and baseline clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 770 patients in the effectiveness set, mean HbA1c decreased by \u22120.3% at 12\u2009weeks and \u22120.5% at 24\u2009weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001 for both). In the sitagliptin group, reductions were \u22120.5% and \u22120.6%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). At 24\u2009weeks, 25.8% and 50.5% of patients achieved HbA1c targets of &lt;\u20096.5% and &lt;\u20097.0%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraclass therapeutic interchange (ICTI) to evogliptin from other DPP\u20104 inhibitors was an effective and well\u2010tolerated strategy for optimizing glycemic control. These findings suggest that intra\u2010class therapeutic interchange could be an effective and well\u2010tolerated strategy for optimizing glycemic control in a clinical setting. However, given the observational nature of this study, further controlled studies are needed to confirm these findings against a comparator group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      NCT04326166\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70270","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:43:19Z","timestamp":1782920599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of Evogliptin for Intra\u2010Class Therapeutic Interchange in Patients With Type 2 Diabetes Mellitus: Subgroup Analysis From A Multi\u2010Center, Prospective, Observational Study (\n                    <scp>REVISE<\/scp>\n                    Study)"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-5769","authenticated-orcid":false,"given":"Jie\u2010Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, CHA Gangnam Medical Center CHA University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-1038","authenticated-orcid":false,"given":"Jun Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Daejeon Eulji Medical Center Eulji University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JaeMyung","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital Hallym University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Soonchunhyang University Cheonan Hospital  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Seo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Daejeon Eulji Medical Center Eulji University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sung Ae General Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KyungWan","family":"Min","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Nowon Eulji Medical Center Eulji University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong Rae Bong Seng Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon Soon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Daejeon Endo Internal Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Global Health Care Esoo Hospital  Asan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hong Ik Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-4083","authenticated-orcid":false,"given":"Jong Chul","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Gimpo 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