{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:03:28Z","timestamp":1785229408956,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet & Metabol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Tirzepatide, a dual GIP\/GLP\u20101 receptor agonist, produces substantial weight loss in adults with obesity. Given ethnic differences in obesity phenotype and cardiometabolic risk, this systematic review and meta\u2010analysis compared tirzepatide's efficacy and safety between Asian and non\u2010Asian adults without diabetes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This PROSPERO\u2010registered review (CRD420261361351) searched PubMed, Scopus, Web of Science and ClinicalTrials.gov through 15 March 2026. Phase 3 SURMOUNT randomised, placebo\u2010controlled trials were classified as Asian (100% Asian participants) or predominantly non\u2010Asian (<\u200925% Asian participants). The primary outcome was the percentage change in body weight. Secondary outcomes included absolute weight change, body mass index (BMI), waist circumference, weight loss thresholds (\u2265\u20095%, \u2265\u200910%, \u2265\u200915%) and adverse events. Random\u2010effects meta\u2010analyses and meta\u2010regression were performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Five trials (six comparisons;\n N<\/jats:italic>\n \u2009=\u20094022) were included: two Asian (SURMOUNT\u2010CN, SURMOUNT\u2010J;\n n<\/jats:italic>\n \u2009=\u2009148 tirzepatide\u2010treated) and four predominantly non\u2010Asian. Tirzepatide 15\u2009mg\/maximum tolerated dose produced an 18.04% greater reduction in body weight versus placebo (95% CI \u221219.86 to \u221216.22;\n p<\/jats:italic>\n \u2009<\u20090.00001,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200977%). Percentage weight loss appeared comparable between Asian (\u221218.16%) and non\u2010Asian (\u221217.92%) trials (\n p<\/jats:italic>\n \u2009=\u20090.94), but this underpowered comparison cannot confirm equivalence. Absolute weight loss was greater in non\u2010Asians (\u221223.46 vs. \u221216.72\u2009kg;\n p<\/jats:italic>\n \u2009=\u20090.03), largely reflecting higher baseline weight. Safety profiles were similar, with no statistically significant interactions by ethnic subgroup.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Tirzepatide provides clinically meaningful weight reduction, with broadly similar relative percentage efficacy across Asian and non\u2010Asian trial populations. These exploratory, indirect findings do not establish ethnic equivalence and require confirmation in adequately powered, ethnicity\u2010stratified trials.<\/jats:p>\n <\/jats:sec>\n \n Registration<\/jats:title>\n The meta\u2010analysis was registered in PROSPERO under the registration number CRD420261361351. The review protocol summary is available on the PROSPERO website.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/edm2.70291","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:21:40Z","timestamp":1784780500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy and Safety of Tirzepatide in Asian and Non\u2010Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-6522","authenticated-orcid":false,"given":"A. B. M.","family":"Kamrul\u2010Hasan","sequence":"first","affiliation":[{"name":"Department of Endocrinology Mymensingh Medical College Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8995-1058","authenticated-orcid":false,"given":"Ibrahim","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Medicine Dhaka Medical College and Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-8805","authenticated-orcid":false,"given":"Deep","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology CEDAR Superspeciality Healthcare Dwarka New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9378-6505","authenticated-orcid":false,"given":"Kunal","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Himachal Heart Institute Mandi Himachal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-5554","authenticated-orcid":false,"given":"Lakshmi","family":"Nagendra","sequence":"additional","affiliation":[{"name":"Department of Endocrinology JSS Medical College, JSS Academy of Higher Education and Research Mysore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-5255","authenticated-orcid":false,"given":"Joseph M.","family":"Pappachan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS Trust Preston UK"},{"name":"Faculty of Science Manchester Metropolitan University Manchester UK"},{"name":"Department of Endocrinology, Kasturba Medical College Manipal Academy of Higher Education Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2025.100375"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2020.772"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(03)15268\u20103"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2023.101315"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2024.102989"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13520"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010026\u201004397\u20104"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2024.20.2.10"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002597\u2010w"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.9217"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(24)00377\u20102"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2404881"},{"key":"e_1_2_12_15_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.4 (Updated August 2023)","author":"Higgins J. 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