{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:59:52Z","timestamp":1790373592780,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radioactive iodine (RAI) therapy is often administered post\u2010total thyroidectomy in patients with low\u2010risk differentiated thyroid carcinoma, despite guidelines advising against its routine application. Evidence regarding the efficacy of RAI in reducing recurrence and improving survival in low\u2010risk differentiated thyroid cancer (DTC) remains inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review and meta\u2010analysis of observational studies and randomized clinical trials that compare RAI versus no RAI in low\u2010risk DTC patients. Databases such as MEDLINE, Scopus, Cochrane Library, and Google Scholar were searched through December 2025. Outcomes included recurrence, recurrence\u2010free survival, treatment response, biochemical markers, and side effects. We performed statistical analysis using Review Manager (RevMan) 5.4 with a random\u2010effects model, reporting odds ratios (OR) with 95% confidence intervals, and significance set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05. Heterogeneity was assessed using\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095260) were included in the analysis. No statistically significant difference was observed between the two groups for recurrence (OR 0.66, 95% CI: 0.41\u20131.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10), 5\u2010year recurrence\u2010free survival (OR 2.47, 95% CI: 0.63\u20139.62;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19), or treatment response (excellent response: OR 1.00, 95% CI: 0.52\u20131.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00). Secondary outcomes, including serum thyroglobulin &gt;\u20091\u2009ng\/mL (OR 1.20, 95% CI: 0.00\u2013342.55;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.95), elevated thyroglobulin antibodies (OR 0.91, 95% CI: 0.38\u20132.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.83), xerostomia (OR 5.63, 95% CI: 0.05\u2013667.24;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.48), and dysphonia (OR 0.96, 95% CI: 0.53\u20131.72;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.88), were also not significantly different between groups, although estimates were not precise.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The available randomized and observational evidence does not demonstrate a clear, clinically meaningful benefit of routine RAI ablation in patients classified as low\u2010risk DTC. These findings should be interpreted with caution due to heterogeneity across studies, variability in outcome definitions, and the predominance of observational data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70293","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:20:04Z","timestamp":1785302404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reassessing Radioactive Iodine Use After Thyroidectomy in Low\u2010Risk Differentiated Thyroid Cancer: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8086-000X","authenticated-orcid":false,"given":"Maheen","family":"Asif","sequence":"first","affiliation":[{"name":"Services Institute of Medical Sciences  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7133-3180","authenticated-orcid":false,"given":"Mudasar","family":"Nisar","sequence":"additional","affiliation":[{"name":"Services Institute of Medical Sciences  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6026-2769","authenticated-orcid":false,"given":"Aliza","family":"Asif","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1430-1940","authenticated-orcid":false,"given":"Makzooma","family":"Batool","sequence":"additional","affiliation":[{"name":"Services Institute of Medical Sciences  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2087-4951","authenticated-orcid":false,"given":"Rabia Javed","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Services Institute of Medical Sciences  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Hammad Jaber","family":"Amin","sequence":"additional","affiliation":[{"name":"Alzaiem Alazhari University  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2022.101687"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.26348"},{"key":"e_1_2_13_4_1","volume-title":"Thyroid Cancer\u2014Cancer Stat Facts","author":"National Cancer Institute"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-023-00818-1"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0392"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2017.1399214"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111953"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000468927"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14950"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12986-0"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_13_16_1","unstructured":"Ottawa Hospital Research Institute \u201cNewcastle\u2010Ottawa Scale (NOS) \u201dhttps:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"e_1_2_13_17_1","unstructured":"The Cochrane Collaboration \u201cReview Manager (RevMan) [Computer Program]. 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