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Zetterlings stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF23OC0084483"],"award-info":[{"award-number":["NNF23OC0084483"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF25OC0101843"],"award-info":[{"award-number":["NNF25OC0101843"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007366","name":"Agnes och Mac Rudbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011751","name":"Stiftelsen f\u00f6r Strategisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2024\u201003344"],"award-info":[{"award-number":["2024\u201003344"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005423","name":"Akademiska Sjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity and Type 2 diabetes (T2D) impair health\u2010related quality of life (HRQoL) across metabolic, mechanical and mental domains. Gastric bypass surgery improves HRQoL in the short term, but long\u2010term trajectories remain insufficiently understood. This study evaluated HRQoL 8\u2009years after gastric bypass in a cohort with T2D, integrating quantitative assessments with qualitative exploration of lived experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eleven individuals with obesity and T2D who underwent gastric bypass participated in an 8\u2010year follow\u2010up. Anthropometric and clinical data were collected. HRQoL was assessed using the RAND SF\u201036, and changes over time were analyzed using repeated\u2010measures ANOVA. Correlations between changes in BMI, HbA1c and HRQoL domains were assessed with Spearman correlations. Semi\u2010structured qualitative interviews were conducted, transcribed verbatim and analyzed using reflexive thematic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants experienced modest weight regain but significant deterioration in glucose control from the 2\u2010year to the 8\u2010year follow\u2010up. RAND SF\u201036 scores returned to preoperative levels, and the mental health score was significantly reduced compared to the 2\u2010year follow\u2010up (\n                      <jats:italic>q<\/jats:italic>\n                      \u2009&lt;\u20090.01). Weight regain correlated with reduced physical functioning, role\u2010physical and vitality scores (all\n                      <jats:italic>r<\/jats:italic>\n                      \u2009&lt;\u2009\u22120.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while HbA1c increase correlated with poorer mental health and role\u2010emotional scores (all\n                      <jats:italic>r<\/jats:italic>\n                      \u2009&lt;\u2009\u22120.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Qualitative interviews revealed that long\u2010term HRQoL was dynamic and shaped by an interplay of physical functioning, psychological wellbeing, body adaptations, social support and life events. An overarching theme emerged:\n                      <jats:italic>Quality of life after gastric bypass is a multidimensional, evolving process influenced by changing health, life circumstances and psychosocial factors over time<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Initial postoperative improvements in HRQoL were not sustained at 8\u2009years and might have been influenced by weight regain, T2D relapse and intercurrent illness. However, lived experiences highlighted meaningful and durable benefits in physical functioning and self\u2010perception for several participants. The findings underscore the need for long\u2010term, holistic follow\u2010up that integrates metabolic monitoring with psychological and social support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov registration: NCT02729246<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70315","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:29:27Z","timestamp":1787131767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Qualitative and Quantitative Health\u2010Related Quality\u2010of\u2010Life Outcomes From an 8\u2010year Follow\u2010Up After Gastric Bypass Surgery in People With Type 2 Diabetes"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-8909","authenticated-orcid":false,"given":"Giovanni","family":"Fanni","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Clinical Diabetology and Metabolism Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-3372","authenticated-orcid":false,"given":"Petros","family":"Katsogiannos","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Diabetology and Metabolism Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-2859","authenticated-orcid":false,"given":"Magnus","family":"Sundbom","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8682-2045","authenticated-orcid":false,"given":"Janeth","family":"Leksell","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Diabetology and Metabolism Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0106-2839","authenticated-orcid":false,"given":"Eva","family":"Randell","sequence":"additional","affiliation":[{"name":"Department of Social Work Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/DOM.16263"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(14)70219\u20100"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/QJMED\/HCT075"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20662"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/DOM.16364"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/JENDSO\/BVAE027"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/DC24\u20102046"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010020\u201000597\u20101"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC\u201022\u20100172"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab398"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010020\u201002203\u2010w"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010005\u20102096\u20104"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010031\u201013942\u20100_2"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19159078"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0332276"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00049530.2022.2046445"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/2159676X.2019.1640779"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010015\u20102456\u20100"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010021\u201001270\u2010w"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010024\u201001606\u20103"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.679006"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2019.12.011"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010022\u201006018\u20108"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00049530.2023.2292022"}],"container-title":["Endocrinology, Diabetes &amp; 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