{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:51:57Z","timestamp":1791978717981,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate metabolic outcomes in women with and without Polyendocrine Metabolic Ovarian Syndrome (PMOS, formerly Polycystic Ovary Syndrome (PCOS))) receiving multidisciplinary care through a women's health telehealth platform that combines physician and registered dietitian support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort analysis of 919 women with BMI \u2265\u200925 initiating care in 2024, with \u2265\u20096\u2009months follow\u2010up (mean 9.6\u2009months). Participants included 557 with PMOS and 362 without. Outcomes extracted from the electronic health record (EHR) included change in weight, HbA1c, HOMA\u2010IR, fasting insulin, fasting glucose, ALT, AST and total cholesterol between baseline and last measured value. Linear regression models adjusted for baseline values of each outcome, age, BMI, race\/ethnicity and follow\u2010up time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant improvements were observed across all metabolic markers for the group overall: HOMA\u2010IR (\u221214.0%), fasting insulin (\u221215.6%), fasting glucose (\u221213.0%), HbA1c (\u22126.2%), ALT (\u221221.2%), AST (\u221225.5%), total cholesterol (\u22128.0%) and weight (\u22124.9%). PCOS status was not associated with differential improvement in any outcome after adjustment. GLP\u20101 receptor agonist use was associated with greater weight loss; however, improvements were also observed in the no\u2010medication group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women with PCOS achieved metabolic improvements equivalent to those without PMOS through a multidisciplinary telehealth model despite presenting with a more adverse metabolic profile at baseline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70332","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:29:50Z","timestamp":1791977390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Metabolic Improvements in Women With and Without Polyendocrine Metabolic Syndrome\u00a0via a Multidisciplinary Telehealth Care Platform"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5350-6951","authenticated-orcid":false,"given":"Heather G.","family":"Huddleston","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of California, San Francisco  San Francisco California USA"},{"name":"Allara Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Blank","sequence":"additional","affiliation":[{"name":"Allara Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Sommers","sequence":"additional","affiliation":[{"name":"Allara Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hellman","sequence":"additional","affiliation":[{"name":"Allara Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Ramallo","sequence":"additional","affiliation":[{"name":"Allara Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Pham","sequence":"additional","affiliation":[{"name":"Allara Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-2273","authenticated-orcid":false,"given":"Karla","family":"Lindquist","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad463"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab613"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201021\u20100669"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13497"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae556"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24169"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201024\u20100269"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033572"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2022.01.005"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.70332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/edm2.70332","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.70332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:29:51Z","timestamp":1791977391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edm2.70332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/edm2.70332"],"URL":"https:\/\/doi.org\/10.1002\/edm2.70332","archive":["Portico"],"relation":{},"ISSN":["2398-9238","2398-9238"],"issn-type":[{"value":"2398-9238","type":"print"},{"value":"2398-9238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"2026-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70332"}}