{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:51:25Z","timestamp":1791931885514,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This prospective study (NCT06283641) was the first real\u2010world, multicentre, post\u2010marketing surveillance of GLP\u20101 receptor agonist liraglutide as an adjunct for weight management in adults with obesity in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from 14 sites at baseline, week 13 and week 26 (February 2024\u2013January 2025). Safety and effectiveness outcomes, including adverse event (AE) incidence proportions (IPs) and body weight (BW) change, were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 259 adults, 61.0% were female (mean\u2009\u00b1\u2009SD age 42.6\u2009\u00b1\u200911.3\u2009years, BW 90.4\u2009\u00b1\u200917.6\u2009kg, BMI 33.0\u2009\u00b1\u20094.7\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Dyslipidaemia (38.2%), hypertension (26.3%), and diabetes (21.2%) were common. Mean daily and maximum doses were 1.4\u2009\u00b1\u20090.5 and 1.8\u2009\u00b1\u20090.7\u2009mg\/day, respectively. Overall IP of AEs was 11.2%; 90.9% of events were mild. General\/injection\u2010site and gastrointestinal events were most frequent. Medication cost (49.0%) was the predominant factor for dose non\u2010escalation. At weeks 13 and 26, mean BW loss was \u22125.7\u2009\u00b1\u20093.5 and \u22128.5\u2009\u00b1\u20095.7\u2009kg (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001; \u2265\u20095% BW loss in 58.4% and 76.7%) and mean systolic blood pressure decrease was 9.0\u2009\u00b1\u200916.7 and 10.4\u2009\u00b1\u200918.9\u2009mmHg, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Liraglutide at &lt;\u20093.0\u2009mg\/day was well\u2010tolerated, with BW reduction observed over 26\u2009weeks in Taiwanese adults. Medication cost is a barrier to long\u2010term obesity management and a significant consideration for health policies in Taiwan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70333","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:31:56Z","timestamp":1789835516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Liraglutide in Adults With Obesity: A Multicentre, Single\u2010Arm, Post\u2010Marketing Surveillance Study in Taiwan"],"prefix":"10.1002","volume":"9","author":[{"given":"Shih\u2010Te","family":"Tu","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Changhua Christian Hospital  Changhua 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