{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:58:46Z","timestamp":1790830726583,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Dyslipidaemia remains a major contributor to atherosclerotic cardiovascular disease (ASCVD), and many patients fail to achieve recommended low\u2010density lipoprotein cholesterol (LDL\u2010C) targets despite statin therapy or are unable to tolerate statins. Oral non\u2010statin therapies have emerged as important alternatives; however, their comparative efficacy and safety remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase, Web of Science, and Cochrane Central up to December 2025 for clinical trials evaluating these medications in adults with dyslipidaemia. Primary outcomes were percent and absolute changes in LDL\u2010C, while secondary outcomes included other lipid parameters and safety profile. A frequentist random\u2010effects network meta\u2010analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010three trials comprising 17,021 participants were included. Combination therapies showed the greatest efficacy, with obicetrapib 10\u2009mg plus ezetimibe 10\u2009mg achieving the largest reduction in percent LDL\u2010C (\u221249.15%; 95% CI: \u221259.42 to \u221238.89), followed by bempedoic acid plus ezetimibe (\u221236.90%; 95% CI: \u221244.65 to \u221229.15). Obicetrapib also showed substantial improvements in HDL\u2010C and ApoB. Safety outcomes were generally reassuring, with no significant increase in serious adverse events, myalgia, headache, or elevated liver enzymes; however, treatment discontinuation was higher with bempedoic acid 180\u2009mg and colesevelam 3.75\u2009g. The certainty of evidence was low to very low for many efficacy outcomes, primarily because of heterogeneity and imprecision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral non\u2010statin combination therapies, particularly obicetrapib plus ezetimibe and bempedoic acid plus ezetimibe, provide the most effective LDL\u2010C lowering and are valuable for patients with statin intolerance or residual risk. Ezetimibe remains a well\u2010tolerated option. Long\u2010term cardiovascular outcome trials are needed to confirm clinical benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70353","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:30:38Z","timestamp":1790829038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Oral Non\u2010Statin Lipid\u2010Lowering Therapies in Dyslipidaemia: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3119-2548","authenticated-orcid":false,"given":"Tamer","family":"Hodrob","sequence":"first","affiliation":[{"name":"Faculty of Medicine Al\u2010Quds University  Abu Dis Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-7276","authenticated-orcid":false,"given":"Reem 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