{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:49:43Z","timestamp":1753868983684,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increasing evidence points to beta\u2010cell regeneration in individuals with type 1 diabetes mellitus (type 1 DM) at all stages of the disease. Exercise and glucagon\u2010like peptide\u20101 (GLP\u20101) independently improve beta\u2010cell function and glucose homeostasis in animal studies and in clinical trials in individuals with type 2 diabetes mellitus (type 2 DM). Whether a combination of both, exercise and GLP\u20101, induces a similar effect in individuals with long\u2010lasting type 1 DM remains to be investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In an open\u2010label study, participants with long\u2010standing type 1 DM were randomly assigned to oral sitagliptin 100\u00a0mg daily for 12\u00a0weeks in combination with or without an exercise intervention. The primary end\u2010point was change in the area under the concentration\u2010time curve of C\u2010peptide during a mixed meal tolerance test before and after 12\u00a0weeks of intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 participants were included in the study and treated with sitagliptin, 12 participants were allocated to a 12\u2010week exercise intervention. After 12\u00a0weeks, there was no difference in the change of AUC C\u2010peptide between groups (exercise: 0 [\u22121424 to 1870], no exercise: 2091 [283\u201017\u00a0434]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.09). HDL improved in the exercise intervention group compared to the group with sitagliptin only (exercise: 0.11 [\u22120.09 to 0.27]; no exercise: \u22120.18 [\u22120.24 to 0.01]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). AUC glucose was numerically slightly lower in the exercise intervention group but this did not translate into changes in HbA1c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of exercise and sitagliptin had no effect on beta\u2010cell function in individuals with long\u2010lasting type 1 DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.75","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T03:43:18Z","timestamp":1558669398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exercise and the dipeptidyl\u2010peptidase IV inhibitor sitagliptin do not improve beta\u2010cell function and glucose homeostasis in long\u2010lasting type 1 diabetes\u2014A randomised open\u2010label study"],"prefix":"10.1002","volume":"2","author":[{"given":"Eleonora","family":"Seelig","sequence":"first","affiliation":[{"name":"Clinic of Endocrinology, Diabetes and Metabolism University Hospital Basel Basel Switzerland"},{"name":"Department of Biomedicine University of Basel Basel Switzerland"},{"name":"University of Cambridge Metabolic Research Laboratories, Wellcome Trust\u2010Medical Research Council Institute of Metabolic Science Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-7079","authenticated-orcid":false,"given":"Beckey","family":"Trinh","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Diabetes and Metabolism University Hospital Basel Basel Switzerland"},{"name":"Department of Biomedicine University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henner","family":"Hanssen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Institute of Exercise and Health Sciences University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Schmidt\u2010Trucks\u00e4ss","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Institute of Exercise and Health Sciences University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helga","family":"Ellingsgaard","sequence":"additional","affiliation":[{"name":"The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Christ\u2010Crain","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Diabetes and Metabolism University Hospital Basel Basel Switzerland"},{"name":"Department of Biomedicine University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Y.","family":"Donath","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Diabetes and Metabolism University Hospital Basel Basel Switzerland"},{"name":"Department of Biomedicine University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60591-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2016.08.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0676"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.832"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0647"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1206"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32959"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051530"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1949-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12164"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/isl.2.3.11396"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2080-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.48"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.380"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00056.2004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2513"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00434.2007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06400"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.4.928"},{"issue":"6","key":"e_1_2_10_23_1","first-page":"732","article-title":"Attenuation 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