{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:49:51Z","timestamp":1753868991755,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Intraperitoneal (IP) insulin administration is a last\u2010resort treatment option for selected patients with type 1 diabetes mellitus (T1DM). As the IP route of insulin administration mimics the physiology more closely than the subcutaneous (SC) route, we hypothesized that IP insulin would result in less oxidative stress (expressed as systemic level of free sulphydryl (R\u2010SH) content) compared to SC insulin in subjects with T1DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Prospective, observational case\u2010control study. Serum thiol measurements were performed at baseline and at 26\u00a0weeks in age\u2010 and gender\u2010matched patients with T1DM. Serum\u2010free thiols, compounds with a R\u2010SH group that are readily oxidized by reactive oxygen species, are considered to be a marker of systemic redox status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 176 patients, 39 of which used IP and 141 SC insulin therapy were analysed. Mean baseline R\u2010SH concentration was 248 (31) \u03bcmol\/L. In multivariable analysis, the route of insulin therapy had no impact on baseline R\u2010SH levels. The estimated geometric mean concentrations of R\u2010SH did not differ significantly between both groups: 264 (95% CI 257, 270) for the IP group and 258 (95% CI 254, 261) for the SC group with a difference of 6 (95% CI \u22122, 14) \u03bcmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on R\u2010SH as a marker of systemic oxidative stress, these findings demonstrate that the route of insulin administration, IP or SC, does not influence systemic redox status in patients with T1DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.88","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T08:37:51Z","timestamp":1565253471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Different routes of insulin administration do not influence serum free thiols in type 1 diabetes mellitus"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-6551","authenticated-orcid":false,"given":"Peter R.","family":"van Dijk","sequence":"first","affiliation":[{"name":"The Diabetes Centre Isala Zwolle The Netherlands"},{"name":"Department of Internal Medicine, University Medical Center University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Waanders","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Isala Zwolle The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan J. J.","family":"Logtenberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Diakonessenhuis Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaas H.","family":"Groenier","sequence":"additional","affiliation":[{"name":"The Diabetes Centre Isala Zwolle The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titia M.","family":"Vriesendorp","sequence":"additional","affiliation":[{"name":"The Diabetes Centre Isala Zwolle The Netherlands"},{"name":"Department of Internal Medicine Isala Zwolle The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanne","family":"Kleefstra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center University of Groningen Groningen The Netherlands"},{"name":"Langerhans Medical Research Group Ommen The Netherlands"},{"name":"High &amp; Intensive Care GGZ Drenthe Mental Health Institute Assen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk J. G.","family":"Bilo","sequence":"additional","affiliation":[{"name":"The Diabetes Centre Isala Zwolle The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)89516-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.11.1361"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126974"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.12.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2534"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00099-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-2340"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.1.53"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.8.847"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2000.7727"},{"issue":"2","key":"e_1_2_11_14_1","first-page":"118","article-title":"Continuous intraperitoneal insulin infusion partly restores the glucagon response to hypoglycaemia in type 1 diabetic patients","volume":"26","author":"Oskarsson PR","year":"2000","journal-title":"Diabetes Metab"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978916"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91462-1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0090257"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050604"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2015.08.007"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1473"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12129"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12546"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7083"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.027"},{"issue":"9","key":"e_1_2_11_25_1","first-page":"399","article-title":"Intraperitoneal versus subcutaneous insulin therapy in the treatment of type 1 diabetes mellitus","volume":"73","author":"Dijk PR","year":"2015","journal-title":"Neth J Med"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-008-0437-9"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-13-0089"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.07.005"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"issue":"2","key":"e_1_2_11_30_1","first-page":"257","article-title":"Antioxidant protection against hypochlorous acid in human plasma","volume":"121","author":"Hu ML","year":"1993","journal-title":"J Lab Clin Med"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03127.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2011.07.2310"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1774"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2015.0001"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.5152\/etd.2018.0059"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.050"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0784-6"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.88","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/edm2.88","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.88","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T03:41:07Z","timestamp":1694230867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edm2.88"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,8]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/edm2.88"],"URL":"https:\/\/doi.org\/10.1002\/edm2.88","archive":["Portico"],"relation":{},"ISSN":["2398-9238","2398-9238"],"issn-type":[{"type":"print","value":"2398-9238"},{"type":"electronic","value":"2398-9238"}],"subject":[],"published":{"date-parts":[[2019,8,8]]},"assertion":[{"value":"2019-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00088"}}