{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:55:39Z","timestamp":1773053739547,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3429,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The role of donor\/recipient gender matching on the long-term rejection process and clinical outcomes following heart transplantation (HT) outcomes is still controversial. We aim to investigate the impact of gender matching on early and long-term outcome HT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The study population comprised 166 patients who underwent HT between 1991 and 2013 and were prospectively followed up in a tertiary referral centre. Early and late outcomes were assessed by the type of donor\u2013recipient gender match (primary analysis: female donor\u2013male recipient [FD\u2013MR, n\u2009=\u200936] vs. male donor\u2013male recipient [MD\u2013MR, n\u2009=\u2009109]). Early mortality, need for inotropic support, length of hospital stay, and major perioperative adverse events did not differ between the FD\u2013MR and MD\u2013MR groups. However, the FD\u2013MR group experienced significantly higher rates of early major rejections per patient as compared with the MD\u2013MR group (1.2\u2009\u00b1\u20091.6 vs. 0.4\u2009\u00b1\u20090.8; P\u2009=\u20090.001), higher rates of overall major rejections (16 vs. 5.5 per 100 person years; P\u2009&amp;lt;\u20090.05), and higher rate of cardiac allograft vasculopathy (43% vs. 20%; P\u2009=\u20090.01). Kaplan\u2013Meier survival analysis showed that the cumulative probabilities of survival free of rejections and major adverse events were significantly higher in MD\u2013MR group (P\u2009=\u20090.002 and 0.001, respectively). Multivariate analysis showed that FD\u2013MR status was associated with &amp;gt;2.5-fold (P\u2009=\u20090.03) increase in the risk for rejections and with a &amp;gt;3-fold (P\u2009=\u20090.01) increase in the risk for major adverse events during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Donor\u2013recipient gender mismatch is a powerful independent predictor of early and late rejections and long-term major adverse events following HT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12107","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T10:21:50Z","timestamp":1472552510000},"page":"31-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Impact of Gender Mismatching on Early and Late Outcomes Following Heart Transplantation"],"prefix":"10.1093","volume":"4","author":[{"given":"Yael","family":"Peled","sequence":"first","affiliation":[{"name":"Heart Transplantation Unit, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]},{"name":"Heart Failure Institute, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Lavee","sequence":"additional","affiliation":[{"name":"Heart Transplantation Unit, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Arad","sequence":"additional","affiliation":[{"name":"Heart Failure Institute, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yedida","family":"Shemesh","sequence":"additional","affiliation":[{"name":"Heart Transplantation Unit, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Katz","sequence":"additional","affiliation":[{"name":"Heart Rehabilitation Center, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigal","family":"Kassif","sequence":"additional","affiliation":[{"name":"Heart Transplantation Unit, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elad","family":"Asher","sequence":"additional","affiliation":[{"name":"Heart Transplantation Unit, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Elian","sequence":"additional","affiliation":[{"name":"Heart Transplantation Unit, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yedael","family":"Har-Zahav","sequence":"additional","affiliation":[{"name":"Heart Transplantation Unit, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Heart Rehabilitation Center, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dov","family":"Freimark","sequence":"additional","affiliation":[{"name":"Heart Failure Institute, Heart Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"2026012115135182200_ehf212107-bib-0001","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.healun.2011.08.003","article-title":"The Registry of the International Society for Heart and Lung Transplantation: Twenty-eighth Adult Heart Transplant 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