{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:10:33Z","timestamp":1769116233588,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3391,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aims of the study were to study the demographical and clinicopathological characteristics of patients presenting with heart failure and evaluate the 1\u2009year outcomes and to identify risk predictors if any.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A prospective observational study was conducted in consecutive patients of systolic heart failure. The study was divided into two parts\u2014an initial 6\u2009month enrolment phase followed up for 1\u2009year for major adverse cardiovascular events. All patients were treated according to the Institutional Heart Failure Protocol. Demographical and clinicopathophysiological characteristics were studied, and results were analysed. A total of 143 patients were enrolled. The mean age of subjects was 56.4\u2009years with male subjects constituting almost two-thirds of the study population. The commonest aetiology of heart failure was ischemic with valvular heart disease being the commonest cause of non-ischemic heart failure. Bendopnea, a recently described symptom of heart failure, was found in a significant number of subjects. By univariate analysis, male sex (P\u2009=\u20090.042) and cardiomegaly (P\u2009=\u20090.035) were predictors of rehospitalization, whereas the univariate predictors of mortality were ischemic aetiology (P\u2009=\u20090.000), age\u2009&amp;gt;\u200950\u2009years (P\u2009=\u20090.007), hypertension (P\u2009=\u20090.012), worsening NYHA class (P\u2009=\u20090.003), diabetes mellitus (P\u2009=\u20090.009), and hypokalaemia (P\u2009=\u20090.006). Multivariate analysis performed showed age\u2009&amp;gt;\u200950\u2009years [P\u2009=\u20090.007; OR (CI)\u2009=\u200913.547 (2.034\u201390.238)], NYHA class [P\u2009=\u20090.002; OR (CI)\u2009=\u200932.300 (3.733\u2013276.532)], and hypokalaemia [P\u2009=\u20090.031; OR (CI)\u2009=\u20097.524 (1.208\u201346.862)] as significant predictors of mortality during long-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study will definitely help us to throw more light in identifying risk predictors of heart failure and help in improving clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12119","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T02:22:35Z","timestamp":1476325355000},"page":"16-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Demographical and Clinicopathological Characteristics in Heart Failure and Outcome Predictors: A Prospective, Observational Study"],"prefix":"10.1093","volume":"4","author":[{"given":"Chakanalil Govindan","family":"Sajeev","sequence":"first","affiliation":[{"name":"Department of Cardiology, Government Medical College , Calicut ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreetal","family":"Rajan Nair","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Government Medical College , Calicut ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biju","family":"George","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Government Medical College , Calicut ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopalan Nair","family":"Rajesh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Government Medical College , Calicut ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mangalath Narayanan","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Government Medical College , Calicut ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"2026012115135355000_ehf212119-bib-0001","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/ejhf.319","article-title":"Heart failure as a general pandemic in Asia","volume":"17","author":"Shimokawa","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"2026012115135355000_ehf212119-bib-0002","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.ejheart.2004.09.003","article-title":"Aetiology, comorbidity and drug therapy of chronic heart failure in the real world: the EPICA substudy","volume":"6","author":"Ceia","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"2026012115135355000_ehf212119-bib-0003","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/eurjhf\/hft028","article-title":"Heart failure in elderly patients: distinctive features and unresolved issues","volume":"15","author":"Lazzarini","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2026012115135355000_ehf212119-bib-0004","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11897-012-0115-7","article-title":"Comparing new onset heart failure with reduced ejection fraction and new onset heart failure with preserved ejection fraction: an epidemiologic perspective","volume":"9","author":"Brouwers","year":"2012","journal-title":"Curr Heart Fail Rep"},{"key":"2026012115135355000_ehf212119-bib-0005","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/ejhf.483","article-title":"Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. 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