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However, this autonomic imbalance is unknown in patients with restrictive cardiomyopathy (RCM) even though they have similar symptoms and poor quality of life as DCM patients have. The aim of this study was to evaluate if autonomic and neurovascular controls were altered in RCM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Fifteen RCM patients, 10 DCM patients, and 10 healthy subjects were evaluated. Heart rate and blood pressure (BP) were recorded. Peripheral sympathetic activity [muscle sympathetic nerve activity (MSNA)] by microneurography and cardiac sympathetic activity by power spectrum analysis of heart rate variability. Spontaneous baroreflex sensitivity (BRS) was evaluated by the sequence method and forearm blood flow by venous occlusion plethysmography. Both cardiomyopathy groups had higher MSNA frequency (P &amp;lt; 0.001) and MSNA incidence (P &amp;lt; 0.001), higher cardiac sympathovagal balance (P &amp;lt; 0.02), reduced BRS for increase (P = 0.002) and for decrease in BP (P = 0.002), and lower forearm blood flow (P &amp;lt; 0.001) compared with healthy subjects. We found an inverse correlation between BRS for increase and decrease in BP and peripheral sympathetic activity (r = \u22120.609, P = 0.001 and r = \u22120.648, P &amp;lt; 0.001, respectively) and between BRS for increase and decrease in BP and cardiac sympathetic activity (r = \u22120.503, P = 0.03 and r = \u22120.487, P = 0.04, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The RCM patients had cardiac and peripheral autonomic dysfunctions associated with peripheral vasoconstriction. Nonetheless, the presence of normal ejection fraction underestimates the evolution of the disease and makes clinical treatment difficult. These alterations could lead to a similar cardiovascular risk as that observed in DCM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12142","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T02:28:46Z","timestamp":1490840926000},"page":"341-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac and Peripheral Autonomic Control in Restrictive Cardiomyopathy"],"prefix":"10.1093","volume":"4","author":[{"given":"Ana Luiza C.","family":"Sayegh","sequence":"first","affiliation":[{"name":"Clinical Unit of Cardiomyopathy, Heart Institute (InCor), University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo R.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Cardiovascular Rehabilitation and Exercise Physiology Unit, Heart Institute (InCor), University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana O.","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Cardiovascular Rehabilitation and Exercise Physiology Unit, Heart Institute (InCor), University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis R.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Cardiovascular Rehabilitation and Exercise Physiology Unit, Heart Institute (InCor), University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera M.C.","family":"Salemi","sequence":"additional","affiliation":[{"name":"Clinical Unit of Heart Failure, Heart Institute (InCor), University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane T.","family":"Hotta","sequence":"additional","affiliation":[{"name":"Clinical Unit of Cardiomyopathy, Heart Institute (InCor), University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akothirene Cristhina D.B.","family":"Marques","sequence":"additional","affiliation":[{"name":"Cardiovascular Rehabilitation and Exercise Physiology Unit, Heart Institute (InCor), University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrum H.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Departmente of Neurology, Justus-Liebig-University , Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivani 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