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We sought the relationship of specific electrocardiographic (ECG) markers of SBHF to echocardiographic features of SBHF and their prognostic value for development of HF. The ECG markers were Cornell product (Cornell-P), P-wave terminal force in lead V1 (PTFV1), ST depression in lead V5 V6 (minSTmV5V6), and increased heart rate. Echocardiographic assessment of SBHF included left ventricular hypertrophy (LVH), impaired global longitudinal strain (GLS), and diastolic dysfunction (DD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and results<\/jats:title>\n                    <jats:p>Asymptomatic subjects \u226565 years without prior cardiac history, but with HF risks, were recruited from the local community. At baseline, they underwent clinical assessment, 12-lead ECG, and comprehensive echocardiography. New HF was assessed clinically at mean follow-up of 14 \u00b1 4 months, and echocardiography was repeated in subjects with HF. Of the 447 study subjects (age 71 \u00b1 5, 47% men) with SBHF, 13% had LVH, 32% impaired GLS, and 65% \u2265grade I DD (10% \u2265grade II DD). Forty were lost to follow-up. Clinical HF developed in 47 of 407, of whom 20% had echocardiographic LVH, 51% abnormal GLS, and 76% DD at baseline. Baseline LVH and abnormal GLS (not grade I DD) were independently associated with outcomes (clinical HF and cardiovascular death). Cornell-P and heart rate (not minSTmV5V6 nor PTFV1) were independently associated with LVH, impaired GLS, and DD. Cornell-P and minSTV5V6 (not heart rate nor PTFV1) were independently associated with outcomes. More ECG abnormalities improved sensitivity, but ECG-markers were not independent of or incremental to echocardiographic markers to predict HF in SBHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this elderly study population, ECG markers showed low diagnostic sensitivity for non-ischaemic SBHF and low prognostic value for outcomes. Cornell-P and minSTmV5V6 had predictive value for outcomes in non-ischaemic SBHF independent of age, gender, and common comorbidities but were not incremental to echocardiography.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12151","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T11:54:02Z","timestamp":1492084442000},"page":"417-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association Between Electrocardiographic and Echocardiographic Markers of Stage B Heart Failure and Cardiovascular Outcome"],"prefix":"10.1093","volume":"4","author":[{"given":"Hong","family":"Yang","sequence":"first","affiliation":[{"name":"Menzies Institute for Medical Research , Hobart ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Marwick","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research , Hobart ,","place":["Australia"]},{"name":"Baker-IDI Heart and Diabetes Institute , Melbourne ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research , Hobart ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Nolan","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research , Hobart ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Negishi","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research , Hobart ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Khan","sequence":"additional","affiliation":[{"name":"Royal Hobart Hospital , Hobart ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Okin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"2026012115152927700_ehf212151-bib-0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2008.11.013","article-title":"2009 focused update incorporated into the ACC\/AHA 2005 guidelines for the diagnosis and management of heart failure in adults","volume":"53","author":"Hunt","year":"2009","journal-title":"Journal of the American College of Cardiology."},{"key":"2026012115152927700_ehf212151-bib-0002","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jacc.2014.10.044","article-title":"Exercise limitation associated with asymptomatic left ventricular impairment: analogy with stage B heart failure","volume":"65","author":"Kosmala","year":"2015","journal-title":"J Am Coll Cardiol."},{"key":"2026012115152927700_ehf212151-bib-0003","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM199209033271003","article-title":"Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. 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