{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:42:23Z","timestamp":1769089343723,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3129,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report the case of a 55-year-old woman with heart failure with preserved ejection fraction (HFpEF), who presented with hypertensive urgency and pulmonary oedema. The patient was medically optimized and underwent cardiac catheterization revealing pulmonary hypertension, elevated pulmonary capillary wedge pressure, normal cardiac index, and non-obstructive coronary disease. Invasive evaluation of coronary flow revealed blunted coronary flow reserve and increased index of microvascular resistance. Cardiac magnetic resonance imaging demonstrated reduced global myocardial perfusion and diffuse interstitial fibrosis. This case exhibits a potential HFpEF phenotype associated with microvascular dysfunction, fibrosis, and elevated filling pressures.<\/jats:p>","DOI":"10.1002\/ehf2.12170","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T04:44:40Z","timestamp":1498452280000},"page":"645-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Microvascular Dysfunction and Cardiac Fibrosis in Heart Failure with Preserved Ejection Fraction: A Case Report"],"prefix":"10.1093","volume":"4","author":[{"given":"Nikhil","family":"Narang","sequence":"first","affiliation":[{"name":"Section of Cardiology, Department of Medicine, University of Chicago , Chicago, IL, 60637 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Medvedofsky","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine, University of Chicago , Chicago, IL, 60637 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Dryer","sequence":"additional","affiliation":[{"name":"Pritzker School of Medicine, University of Chicago , Chicago, IL, 60637 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL, 60611 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine, University of Chicago , Chicago, IL, 60637 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.A.","family":"Blair","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine, University of Chicago , Chicago, IL, 60637 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,6,26]]},"reference":[{"key":"2026012115152277800_ehf212170-bib-0001","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.080770","article-title":"Get with the Guidelines Scientific Advisory C, Investigators. Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes","volume":"126","author":"Steinberg","year":"2012","journal-title":"Circulation"},{"key":"2026012115152277800_ehf212170-bib-0002","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1056\/NEJMcp1511175","article-title":"Heart failure with preserved ejection fraction","volume":"375","author":"Redfield","year":"2016","journal-title":"N Engl J Med"},{"key":"2026012115152277800_ehf212170-bib-0003","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.003116","article-title":"Predicting heart failure with preserved and reduced ejection fraction: the international collaboration on heart failure subtypes","volume":"9","author":"Ho","year":"2016","journal-title":"Circ Heart 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