{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:25:01Z","timestamp":1791465901191,"version":"4.3.4"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3110,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T00:00:00Z","timestamp":1500076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001655","name":"German Academic Exchange Service","doi-asserted-by":"publisher","award":["A\/08\/76145"],"award-info":[{"award-number":["A\/08\/76145"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["A\/08\/76145"],"award-info":[{"award-number":["A\/08\/76145"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cachexia is a severe complication of cancer that adversely affects the course of the disease and is associated with high rates of mortality. Patients with cancer manifest symptoms, such as fatigue, shortness of breath, and impaired exercise tolerance, which are clinical signs of chronic heart failure. The aim of this study was to evaluate cardiac muscle wasting in cancer individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively analysed 177 individuals who died of cancer, including 58 lung, 60 pancreatic, and 59 gastrointestinal (GI) cancers, and 42 cancer-free controls who died of other, non-cardiovascular reasons. Cancer cachexia (CC) was defined based on clinical and\/or pathological diagnosis, body mass index (BMI) &amp;lt;20.0 kg\/m2 and\/or oedema-free body weight loss of 5.0% during the previous year or less. The pathology reports were analysed for BMI, heart weight (HW), and left and right ventricular wall thicknesses (LVWT and RVWT, respectively). The analysis of clinical data included recording of biochemical parameters and medication data of study patients. CC was detected in 54 (30.5%) subjects. Individuals with CC had a significantly lower HW than non-cachectic subjects (363.1 \u00b1 86.2 vs. 447.0 \u00b1 128.9 g, P &amp;lt; 0.001) and control group (412.9 \u00b1 75.8 g, P &amp;lt; 0.05). BMI correlated with HW in cases with GI cancer (r = 0.44, P &amp;lt; 0.001), lung cancer (r = 0.53, P &amp;lt; 0.0001), and pancreatic cancer (r = 0.39, P &amp;lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Body weight loss in individuals with lung, pancreatic, and GI cancers is accompanied by a decrease in HW. In patients with CC who receive cancer treatment, screening for cardiac muscle wasting may have clinical importance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12184","type":"journal-article","created":{"date-parts":[[2017,7,16]],"date-time":"2017-07-16T00:06:35Z","timestamp":1500163595000},"page":"458-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Cardiac Muscle Wasting in Individuals with Cancer Cachexia"],"prefix":"10.1093","volume":"4","author":[{"given":"Anush","family":"Barkhudaryan","sequence":"first","affiliation":[{"name":"Clinic of General and Invasive Cardiology, University Clinical Hospital No. 1 , Yerevan ,","place":["Armenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Scherbakov","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin, Charite Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK) , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Springer","sequence":"additional","affiliation":[{"name":"Institute of Innovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Centre G\u00f6ttingen (UMG) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Doehner","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin, Charite Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK) , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology and Berlin-Brandenburg Center for Regenerative Therapies, Campus Virchow, Charite Universit\u00e4tsmedizin Berlin , Berlin 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