{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:40:57Z","timestamp":1775641257950,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3100,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ClinSearch"},{"name":"ClinSearch France"},{"name":"ClinSearch"},{"name":"ClinSearch France"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Although left ventricular assist devices (LVADs) are currently approved for coverage and reimbursement in France, no French cost-effectiveness (CE) data are available to support this decision. This study aimed at estimating the CE of LVAD compared with medical management in the French health system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Individual patient data from the \u2018French hospital discharge database\u2019 (Medicalization of information systems program) were analysed using Kaplan\u2013Meier method. Outcomes were time to death, time to heart transplantation (HTx), and time to death after HTx. A micro-costing method was used to calculate the monthly costs extracted from the Program for the Medicalization of Information Systems. A multistate Markov monthly cycle model was developed to assess CE. The analysis over a lifetime horizon was performed from the perspective of the French healthcare payer; discount rates were 4%. Probabilistic and deterministic sensitivity analyses were performed. Outcomes were quality-adjusted life years (QALYs) and incremental CE ratio (ICER). Mean QALY for an LVAD patient was 1.5 at a lifetime cost of \u20ac190 739, delivering a probabilistic ICER of \u20ac125 580\/QALY [95% confidence interval: 105 587 to 150 314]. The sensitivity analysis showed that the ICER was mainly sensitive to two factors: (i) the high acquisition cost of the device and (ii) the device performance in terms of patient survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our economic evaluation showed that the use of LVAD in patients with end-stage heart failure yields greater benefit in terms of survival than medical management at an extra lifetime cost exceeding the \u20ac100 000\/QALY. Technological advances and device costs reduction shall hence lead to an improvement in overall CE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12194","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T06:58:33Z","timestamp":1500965913000},"page":"75-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cost-Effectiveness of Left Ventricular Assist Devices for Patients with End-Stage Heart Failure: Analysis of the French Hospital Discharge Database"],"prefix":"10.1093","volume":"5","author":[{"given":"Abir","family":"Tadmouri","sequence":"first","affiliation":[{"name":"Health Economics and Outcome Research (HEOR) Department, ClinSearch , Malakoff ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefin","family":"Blomkvist","sequence":"additional","affiliation":[{"name":"Health Economics and Outcome Research (HEOR) Department, ClinSearch , Malakoff ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Landais","sequence":"additional","affiliation":[{"name":"Health Economics and Outcome Research (HEOR) Department, ClinSearch , Malakoff ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Seymour","sequence":"additional","affiliation":[{"name":"Health Economics and Outcome Research (HEOR) Department, ClinSearch , Malakoff ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Azmoun","sequence":"additional","affiliation":[{"name":"H\u00f4pital Marie Lannelongue , Le Plessis-Robinson ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"2026012115121429500_ehf212194-bib-0001","volume-title":"Rapport annuel de l'Agence de la biom\u00e9decine 2013","author":"l'Agence de la biom\u00e9decine","year":"2013"},{"key":"2026012115121429500_ehf212194-bib-0002","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/j.jacc.2015.04.039","article-title":"Left ventricular assist devices: a rapidly evolving alternative to transplant","volume":"65","author":"Mancini","year":"2015","journal-title":"Journal of the American College of Cardiology."},{"key":"2026012115121429500_ehf212194-bib-0003","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Long-term use of a left ventricular assist device for end-stage heart failure","volume":"345","author":"Rose","year":"2001","journal-title":"The New England Journal of Medicine"},{"key":"2026012115121429500_ehf212194-bib-0004","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.jacc.2014.01.053","article-title":"Results of the destination therapy post-food and drug administration approval study with a continuous flow left ventricular assist device: a prospective study using the INTERMACS registry (Interagency Registry for Mechanically Assisted Circulatory Support)","volume":"63","author":"Jorde","year":"2014","journal-title":"Journal of the American College of Cardiology."},{"key":"2026012115121429500_ehf212194-bib-0005","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.athoracsur.2015.09.013","article-title":"National trends in utilization, mortality, complications, and cost of care after left ventricular assist device implantation from 2005 to 2011","volume":"101","author":"Shah","year":"2016","journal-title":"Ann Thorac Surg."},{"key":"2026012115121429500_ehf212194-bib-0006","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.healun.2006.03.010","article-title":"Hospital costs for left ventricular assist devices for destination therapy: lower costs for implantation in the post-REMATCH era","volume":"25","author":"Miller","year":"2006","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"2026012115121429500_ehf212194-bib-0007","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.112.139824","article-title":"Cost of ventricular assist devices: can we afford the progress?","volume":"127","author":"Miller","year":"2013","journal-title":"Circulation"},{"key":"2026012115121429500_ehf212194-bib-0008","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ijcard.2013.12.015","article-title":"Cost-effectiveness of left ventricular assist devices (LVADs) for patients with advanced heart failure: analysis of the British NHS bridge to transplant (BTT) program","volume":"171","author":"Clarke","year":"2014","journal-title":"International Journal of Cardiology"},{"key":"2026012115121429500_ehf212194-bib-0009","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.healun.2006.09.011","article-title":"Cost-effectiveness of ventricular assist device use in the United Kingdom: results from the evaluation of ventricular assist device programme in the UK (EVAD-UK)","volume":"25","author":"Sharples","year":"2006","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"2026012115121429500_ehf212194-bib-0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1749-8090-7-76","article-title":"Hospital costs fell as numbers of LVADs were increasing: experiences from Oslo University Hospital","volume":"7","author":"Mishra","year":"2012","journal-title":"Journal of Cardiothoracic Surgery"},{"key":"2026012115121429500_ehf212194-bib-0011","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1017\/S0266462313000238","article-title":"Cost-effectiveness of continuous-flow left ventricular assist devices","volume":"29","author":"Neyt","year":"2013","journal-title":"International Journal of Technology Assessment in health care"},{"key":"2026012115121429500_ehf212194-bib-0012","first-page":"439","article-title":"The cost-utility of left ventricular assist devices for end-stage heart failure patients ineligible for cardiac transplantation: a systematic review and critical appraisal of economic evaluations","volume":"3","author":"Neyt","year":"2014","journal-title":"Annals of Cardiothoracic Surgery"},{"key":"2026012115121429500_ehf212194-bib-0013","volume-title":"HTA of ventricular assist devices, Rapport technique, Evaluation de l'assitance circulatoire m\u00e9canique - Service \u00e9valuation des dispositifs, Service \u00e9valuation m\u00e9dico-\u00e9conomique et sant\u00e9 - 2008","author":"Haute Autorit\u00e9 de Sant\u00e9"},{"key":"2026012115121429500_ehf212194-bib-0014","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/CIRCHEARTFAILURE.113.000807","article-title":"Comparative survival and cost-effectiveness of advanced therapies for end-stage heart failure","volume":"7","author":"Long","year":"2014","journal-title":"Circulation Heart Failure"},{"key":"2026012115121429500_ehf212194-bib-0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCHEARTFAILURE.111.962951","article-title":"Cost-effectiveness analysis of continuous-flow left ventricular assist devices as destination therapy","volume":"5","author":"Rogers","year":"2012","journal-title":"Circulation Heart Failure"},{"key":"2026012115121429500_ehf212194-bib-0016","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jtcvs.2009.02.016","article-title":"Left ventricular assist device as destination therapy: application of the payment-by-results approach for the device reimbursement","volume":"138","author":"Messori","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026012115121429500_ehf212194-bib-0017","volume-title":"Choices in methods for economic evaluation\u2014a methodological guide","author":"Haute Autorit\u00e9 de Sant\u00e9","year":"2012"},{"key":"2026012115121429500_ehf212194-bib-0018","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.healun.2011.10.017","article-title":"Cost-effectiveness of the implantable HeartMate II left ventricular assist device for patients awaiting heart transplantation","volume":"31","author":"Moreno","year":"2012","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"2026012115121429500_ehf212194-bib-0019","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.healun.2014.01.003","article-title":"Comparative cost-effectiveness of the HeartWare versus HeartMate II left ventricular assist devices used in the United Kingdom National Health Service bridge-to-transplant program for patients with heart failure","volume":"33","author":"Pulikottil-Jacob","year":"2014","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"2026012115121429500_ehf212194-bib-0020","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1001\/jama.2016.12195","article-title":"Recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses: second panel on cost-effectiveness in health and medicine","volume":"316","author":"Sanders","year":"2016","journal-title":"JAMA"},{"key":"2026012115121429500_ehf212194-bib-0021","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/EDE.0000000000000472","article-title":"Assessment of heart transplant waitlist time and pre- and post-transplant failure: a mixed methods approach","volume":"27","author":"Goldstein","year":"2016","journal-title":"Epidemiology"},{"key":"2026012115121429500_ehf212194-bib-0022","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2014-000109","article-title":"Trends in left ventricular assist device use and outcomes among Medicare beneficiaries, 2004\u20132011","volume":"1","author":"Lampropulos","year":"2014","journal-title":"Open Heart"},{"key":"2026012115121429500_ehf212194-bib-0023","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jjcc.2010.05.010","article-title":"Improved long-term performance of pulsatile extracorporeal left ventricular assist device","volume":"56","author":"Sasaoka","year":"2010","journal-title":"J Cardiol."},{"key":"2026012115121429500_ehf212194-bib-0024","first-page":"1","article-title":"Special report: cost-effectiveness of left-ventricular assist devices as destination therapy for end-stage heart failure","volume":"19","year":"2004","journal-title":"Technol Eval Cent Assess Program Exec Summ"},{"key":"2026012115121429500_ehf212194-bib-0025","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.healun.2015.10.003","article-title":"Seventh INTERMACS annual report: 15,000 patients and counting","volume":"34","author":"Kirklin","year":"2015","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"2026012115121429500_ehf212194-bib-0026","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/01.sla.0000090447.73384.ad","article-title":"Left ventricular assist devices as permanent heart failure therapy: the price of progress","volume":"238","author":"Oz","year":"2003","journal-title":"Ann Surg"},{"key":"2026012115121429500_ehf212194-bib-0027","volume-title":"Invoering van kunst-en steunhart als bestemmingstherapie voor pati\u00ebnten met eindstadium hartfalen\u2014gevolgen voor ziektelast en kosten van behandeling","author":"Adang","year":"2006"},{"key":"2026012115121429500_ehf212194-bib-0028","first-page":"1712","article-title":"Should eligibility for heart transplantation be a requirement for left ventricular assist device use? Recommendations based on a systematic review","volume":"29","author":"Boothroyd","year":"2013","journal-title":"Can J Cardiol"},{"key":"2026012115121429500_ehf212194-bib-0029","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.healun.2011.12.001","article-title":"The Fourth INTERMACS Annual Report: 4,000 implants and counting","volume":"31","author":"Kirklin","year":"2012","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"2026012115121429500_ehf212194-bib-0030","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1056\/NEJMoa0909938","article-title":"Advanced heart failure treated with continuous-flow left ventricular assist device","volume":"361","author":"Slaughter","year":"2009","journal-title":"The New England Journal of Medicine"},{"key":"2026012115121429500_ehf212194-bib-0031","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jacc.2010.10.040","article-title":"Multicenter evaluation of an intrapericardial left ventricular assist system","volume":"57","author":"Strueber","year":"2011","journal-title":"Journal of the American College of Cardiology"},{"key":"2026012115121429500_ehf212194-bib-0032","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0735-1097(02)01751-5","article-title":"Left ventricular assist device therapy improves utilization of donor hearts","volume":"39","author":"Aaronson","year":"2002","journal-title":"Journal of the American College of Cardiology"},{"key":"2026012115121429500_ehf212194-bib-0033","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1524-4733.2008.00425.x","article-title":"Utility estimates for decision-analytic modeling in chronic heart failure\u2014health states based on New York Heart Association classes and number of rehospitalizations","volume":"12","author":"Gohler","year":"2009","journal-title":"Value in Health"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fehf2.12194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/5\/1\/75\/66137609\/eschf_5_1_75.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/5\/1\/75\/66137609\/eschf_5_1_75.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:16:23Z","timestamp":1769026583000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/5\/1\/75\/8403971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,7,25]]},"published-print":{"date-parts":[[2018,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.12194","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2]]},"published":{"date-parts":[[2017,7,25]]},"assertion":[{"value":"2017-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}