{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:17:56Z","timestamp":1769087876557,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3101,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR-THC135230"],"award-info":[{"award-number":["CIHR-THC135230"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR\u2010THC135230"],"award-info":[{"award-number":["CIHR\u2010THC135230"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Previous studies have examined risk factors for the development of heart failure (HF) subsequent to acute coronary syndrome (ACS). Our study seeks to clarify the clinical variables that best characterize patients who remain free from HF after coronary artery bypass grafting (CABG) surgery for ACS to determine novel biological factors favouring freedom from HF in prospective translational studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Nova Scotia residents (1995\u20132012) undergoing CABG within 3 weeks of ACS were included. The primary outcome was freedom from readmission to hospital due to HF. Descriptive statistics were generated, and a Cox proportional hazards model assessed outcome with adjustment for clinical characteristics. Of 11 936 Nova Scotians who underwent isolated CABG, 3264 (27%) had a recent ACS and were included. Deaths occurred in 210 (6%) of subjects prior to discharge. A total of 3054 patients were included in the long-term analysis. During follow-up, HF necessitating readmission occurred in 688 (21%) subjects with a hazard ratio of 12% at 2 years. The adjusted Cox model demonstrated significantly better freedom from HF for younger, male subjects without metabolic syndrome and no history of chronic obstructive pulmonary disease, renal insufficiency, atrial fibrillation, or HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings have outlined important clinical variables that predict freedom from HF. Furthermore, we have shown that 12% of patients undergoing CABG after ACS develop HF (2 years). Our findings support our next phase in which we plan to prospectively collect blood and tissue specimens from ACS patients undergoing CABG in order to determine novel biological mechanism(s) that favour resolution of post-ACS inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12197","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T05:46:49Z","timestamp":1500875209000},"page":"107-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recovery Free of Heart Failure After Acute Coronary Syndrome and Coronary Revascularization"],"prefix":"10.1093","volume":"5","author":[{"given":"Alec","family":"Falkenham","sequence":"first","affiliation":[{"name":"Department of Pathology, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj K.","family":"Saraswat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareem","family":"Gawdat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahanara","family":"Begum","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen J.","family":"Buth","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Haidl","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Francois","family":"L\u00e9gar\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]},{"name":"Department of Surgery, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"2026012115122021200_ehf212197-bib-0001","first-page":"S442","article-title":"The epidemic of heart failure: a lucid approach to stemming the rising tide","volume":"30","author":"O'Meara","year":"2014","journal-title":"Can J Cardiol"},{"key":"2026012115122021200_ehf212197-bib-0002","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.amjcard.2015.05.020","article-title":"Comparison of 5-year outcomes after coronary artery bypass grafting in heart failure patients with versus without preserved left ventricular ejection fraction (from the CREDO-Kyoto CABG Registry Cohort-2)","volume":"116","author":"Marui","year":"2015","journal-title":"Am J Cardiol"},{"key":"2026012115122021200_ehf212197-bib-0003","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1056\/NEJMoa1205512","article-title":"Prasugrel versus clopidogrel for acute coronary syndromes without revascularization","volume":"367","author":"Roe","year":"2012","journal-title":"N Engl J Med"},{"key":"2026012115122021200_ehf212197-bib-0004","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1056\/NEJM199907223410402","article-title":"Sex, clinical presentation, and outcome in patients with acute coronary syndromes. 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