{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:21:08Z","timestamp":1790785268706,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3042,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"the Ministry of Health, Labor and Welfare, Japan","doi-asserted-by":"publisher","award":["H18-Junkanki-tou (Seishuu)-Ippan-046"],"award-info":[{"award-number":["H18-Junkanki-tou (Seishuu)-Ippan-046"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labor and Welfare, Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Ministry of Health, Labor and Welfare, Japan","award":["H18-Junkanki-tou (Seishuu)-Ippan-046"],"award-info":[{"award-number":["H18-Junkanki-tou (Seishuu)-Ippan-046"]}]},{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health, Labor and Welfare, Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiac function varies in the population of patients with heart failure (HF) with preserved left ventricular ejection fraction (LVEF; HFpEF). This study investigated the heterogeneity of clinical features associated with HF and the prognostic value of BNP levels in patients with HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The study enrolled 288 patients with stable HF and serum creatinine &amp;lt;1.5 mg\/dL who were part of the original J-MELODIC study cohort. They were categorized as having HF with reduced LVEF (HFrEF; EF \u2264 40%, n = 83) or as having HFpEF (EF &amp;gt; 40%, n = 205). Patients with HFpEF were further categorized as having relatively low LVEF (HFrlEF; EF 40\u201360%, n = 107) or as having relatively high LVEF (HFrhEF; EF \u2265 60%, n = 98). We defined cardiovascular death and hospitalization for HF as adverse events and evaluated the prognostic value of the BNP levels in each group. There was no significant difference in event-free survival between HFpEF and HFrEF patients or between HFrhEF and HFrlEF patients. A multivariate Cox proportional hazards model revealed that the BNP level was an independent predictor of adverse events in HFrEF patients (hazard ratio: 4.088, 95% confidence interval: 1.178\u201314.179, P = 0.027) and in HFrlEF patients (hazard ratio: 14.888, 95% confidence interval: 4.969\u201344.608, P &amp;lt; 0.001) but not in HFrhEF patients (P = 0.767).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The BNP level has prognostic value in HFrlEF but not in HFrhEF. This indicates that HFrhEF and HFrlEF are distinct entities that may require different approaches for the management of HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12206","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T04:56:40Z","timestamp":1505969800000},"page":"36-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Prognostic Value of Brain Natriuretic Peptide in Patients with Heart Failure and Left Ventricular Ejection Fraction Higher than 60%: A Sub-Analysis of the J-MELODIC Study"],"prefix":"10.1093","volume":"5","author":[{"given":"Shuichi","family":"Kitada","sequence":"first","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University , Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tsujino","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences , Kobe ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Masuyama","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine , Nishinomiya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Ohte","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University , Nagoya 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