{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:42:18Z","timestamp":1784385738968,"version":"3.55.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3036,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["02.527.11.0007"],"award-info":[{"award-number":["02.527.11.0007"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to assess determinants of anorexia, that is loss of appetite in patients with heart failure (HF) and aimed to further elucidate the association between anorexia, functional capacity, and outcomes in affected patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We assessed anorexia status among 166 patients with HF (25 female, 66 \u00b1 12 years) who participated in the Studies Investigating Co-morbidities Aggravating HF. Anorexia was assessed by a 6-point Likert scale (ranging from 0 to 5), wherein values \u22651 indicate anorexia. Functional capacity was assessed as peak oxygen uptake (peak VO2), 6 min walk test, and short physical performance battery test. A total of 57 patients (34%) reported any anorexia, and these patients showed lower values of peak VO2, 6 min walk distance, and short physical performance battery score (all P &amp;lt; 0.05). Using multivariate analysis adjusting for clinically important factors, only high-sensitivity C-reactive protein [odds ratio (OR) 1.24, P = 0.04], use of loop diuretics (OR 5.76, P = 0.03), and the presence of cachexia (OR 2.53, P = 0.04) remained independent predictors of anorexia. A total of 22 patients (13%) died during a mean follow-up of 22.5 \u00b1 5.1 months. Kaplan-Meier curves for cumulative survival showed that those patients with anorexia presented higher mortality (Log-rank test P = 0.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inflammation, use of loop diuretics, and cachexia are associated with an increased likelihood of anorexia in patients with HF, and patients with anorexia showed impaired functional capacity and poor outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12209","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T06:25:24Z","timestamp":1506493524000},"page":"448-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Anorexia, Functional Capacity, and Clinical Outcome in Patients with Chronic Heart Failure: Results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)"],"prefix":"10.1093","volume":"4","author":[{"given":"Masakazu","family":"Saitoh","sequence":"first","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo R.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]},{"name":"Heart Institute (InCor), University of Sao Paulo Medical School , Sao Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Emami","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Ebner","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Valentova","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Bekfani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, Friedrich-Schiller-University , Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Sandek","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitja","family":"Lainscak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ljubljana, Slovenia; Departments of Cardiology and Research and Education, General Hospital Celje , Celje ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Doehner","sequence":"additional","affiliation":[{"name":"Centre for Stroke Research Berlin and Department of Cardiology, Virchow Klinikum, Charit\u00e9-Universit\u00e4tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]},{"name":"Division of Cardiology and Metabolism \u2013 Heart Failure, Cachexia and Sarcopenia; Department of Internal Medicine and Cardiology, Berlin-Brandenburg Center for Regenerative Therapies (BCRT) at Charit\u00e9 University Medicine , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"2026012115152110700_ehf212209-bib-0001","article-title":"Heart disease and stroke statistics\u20132013 update: a report from the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"2026012115152110700_ehf212209-bib-0002","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/jcsm.12086","article-title":"Adiponectin resistance in skeletal muscle: pathophysiological implications in chronic heart failure","volume":"7","author":"Sente","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2026012115152110700_ehf212209-bib-0003","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/eurheartj\/ehs381","article-title":"Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)","volume":"34","author":"F\u00fclster","year":"2013","journal-title":"Eur Heart J"},{"key":"2026012115152110700_ehf212209-bib-0004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijcard.2016.07.135","article-title":"Sarcopenia in patients with heart failure with preserved ejection fraction: impact on muscle strength, exercise capacity and quality of life","volume":"222","author":"Bekfani","year":"2016","journal-title":"Int J Cardiol"},{"key":"2026012115152110700_ehf212209-bib-0005","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0140-6736(96)07015-8","article-title":"Wasting as independent risk factor for mortality in chronic heart failure","volume":"349","author":"Anker","year":"1997","journal-title":"Lancet"},{"key":"2026012115152110700_ehf212209-bib-0006","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jcsm.12167","article-title":"Prevalence and clinical impact of cachexia in chronic illness in Europe, USA, and Japan: facts and numbers update 2016","volume":"7","author":"von Haehling","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2026012115152110700_ehf212209-bib-0007","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1017\/S0029665115002438","article-title":"The wasting continuum in heart failure: from sarcopenia to cachexia","volume":"74","author":"von Haehling","year":"2015","journal-title":"Proc Nutr Soc"},{"key":"2026012115152110700_ehf212209-bib-0008","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrcardio.2017.51","article-title":"Muscle wasting and cachexia in heart failure: mechanisms and therapies","volume":"14","author":"von Haehling","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"2026012115152110700_ehf212209-bib-0009","first-page":"175","article-title":"The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients","volume":"8","author":"Walsh","year":"2000","journal-title":"Support Care Cancer"},{"key":"2026012115152110700_ehf212209-bib-0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s40520-013-0186-7","article-title":"Societ\u00e0 Italiana per lo Studio della Sarcopenia e della Disabilit\u00e0 Muscolo-Scheletrica (SISDIM). 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