{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:22:44Z","timestamp":1785943364606,"version":"3.56.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3035,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Skane University Hospital","award":["2015-0322"],"award-info":[{"award-number":["2015-0322"]}]},{"name":"WCMM-Lund University","award":["ALFSKANE-675271"],"award-info":[{"award-number":["ALFSKANE-675271"]}]},{"name":"Swedish Heart and Lung Foundation","award":["2015-0322"],"award-info":[{"award-number":["2015-0322"]}]},{"name":"Research Funds of Region Sk\u00e5ne"},{"name":"Kockska Foundation"},{"DOI":"10.13039\/100019649","name":"Southwest Skanes Diabetes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019649","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009761","name":"Hulda and Conrad Mossfelt Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009761","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Skane"},{"name":"Ernhold Lundstroms Research Foundation"},{"DOI":"10.13039\/501100003173","name":"Crafoord Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004817","name":"Medical Faculty of Lund University","doi-asserted-by":"publisher","award":["ALFSKANE-432021"],"award-info":[{"award-number":["ALFSKANE-432021"]}],"id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004817","name":"Medical Faculty of Lund University","doi-asserted-by":"publisher","award":["ALFSKANE-436111"],"award-info":[{"award-number":["ALFSKANE-436111"]}],"id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Orthostatic hypotension (OH) is a cardinal sign of autonomic dysfunction and a common co-morbidity in heart failure (HF). The role of autonomic dysfunction in the development of structural cardiac anomalies in HF patients has not been sufficiently explored. We aimed to assess relations between orthostatic blood pressure (BP) responses during active standing and echocardiographic changes in a series of patients admitted for HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>One hundred and forty-nine patients hospitalized for HF [mean age: 74 years; 30% women; ejection fraction (LVEF) 40 \u00b1 16%] were examined with conventional echocardiograms and active-standing test. Associations of cardiac remodelling parameters with the difference between supine and standing (after 3 min) systolic\/diastolic BP were examined. Systolic BP decreased (\u22121.1 \u00b1 15 mmHg), whereas diastolic BP increased (+1.0 \u00b1 9.5 mmHg) after 3 min of active standing. A total of 34 patients (23%) met conventional OH criteria; i.e. systolic\/diastolic BP decreases by \u226520\/10 mmHg. In the multivariable linear regression analysis, adjusted for traditional cardiovascular risk factors and LVEF, a decrease in systolic BP upon standing was associated with greater left atrial volume [\u03b2 per \u221210 mmHg: 2.37, standard error (SE) = 1.16, P = 0.043], and greater left ventricular mass (\u03b2 per \u221210 mmHg: 5.67, SE = 2.24, P = 0.012), but not with other echocardiographic parameters. No significant associations were observed between signs of cardiac remodelling and decrease in diastolic BP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Orthostatic decrease in systolic BP among older HF patients is associated with structural cardiac changes such as increased left atrial volume and left ventricular mass, independently of traditional risk factors and left ventricular dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12223","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T12:04:26Z","timestamp":1506600266000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Autonomic Dysfunction is Associated with Cardiac Remodelling in Heart Failure Patients"],"prefix":"10.1093","volume":"5","author":[{"given":"Amna","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Medical Imaging and Physiology, Lund University, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Molvin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Lund University, Sk\u00e5ne University Hospital , Inga Marie Nillsons Gata 46, 205 02, Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erasmus","family":"Bachus","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Internal Medicine, Lund University, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Tasevska-Dinevska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lund University, Sk\u00e5ne University Hospital , Inga Marie Nillsons Gata 46, 205 02, Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Fedorowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Lund University, Sk\u00e5ne University Hospital , Inga Marie Nillsons Gata 46, 205 02, Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amra","family":"Jujic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Lund University, Sk\u00e5ne University Hospital , Inga Marie Nillsons Gata 46, 205 02, Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"2026012115122205700_ehf212223-bib-0001","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jacc.2015.06.1084","article-title":"Orthostatic hypotension: epidemiology, prognosis, and 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