{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:04:10Z","timestamp":1783533850032,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":3012,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,10,21]],"date-time":"2017-10-21T00:00:00Z","timestamp":1508544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are increasingly frequent in Asia and commonly coexist in patients. However, the prevalence of COPD among Asian patients with HF and its impact on HF treatment are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We compared clinical characteristics and treatment approaches between patients with or without a history of COPD, before and after 1:2 propensity matching (for age, sex, geographical region, income level, and ethnic group) in 5232 prospectively recruited patients with HF and reduced ejection fraction (HFrEF, &amp;lt;40%) from 11 Asian regions (Northeast Asia: South Korea, Japan, Taiwan, Hong Kong, and China; South Asia: India; Southeast Asia: Thailand, Malaysia, Philippines, Indonesia, and Singapore). Among the 5232 patients with HFrEF, a history of COPD was present in 8.3% (n = 434), with significant variation in geography (11.0% in Northeast Asia vs. 4.7% in South Asia), regional income level (9.7% in high income vs. 5.8% in low income), and ethnicity (17.0% in Filipinos vs. 5.2% in Indians) (all P &amp;lt; 0.05). Use of mineralocorticoid receptor antagonists and diuretics was similar between groups, while usage of all \u03b2-blockers was lower in the COPD group than in the non-COPD group in the overall (66.3% vs. 79.9%) and propensity-matched cohorts (66.3% vs. 81.7%) (all P &amp;lt; 0.05). A striking exception was the Japanese cohort in which \u03b2-blocker use was high in COPD and non-COPD patients (95.2% vs. 91.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of COPD in HFrEF varied across Asia and was related to underuse of \u03b2-blockers, except in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12228","type":"journal-article","created":{"date-parts":[[2017,10,22]],"date-time":"2017-10-22T00:06:37Z","timestamp":1508630797000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Chronic Obstructive Pulmonary Disease and \u03b2-Blocker Treatment in Asian Patients with Heart Failure"],"prefix":"10.1093","volume":"5","author":[{"given":"Yoshiaki","family":"Kubota","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Nippon Medical School , Bunky\u014d, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Ting","family":"Tay","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniya","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nippon Medical School , Bunky\u014d, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nippon Medical School , Bunky\u014d, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikutaro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Cerebral and Cardiovascular Center Hospital , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, Tokyo Women's Medical University , Shinjuku, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Omori Hospital , \u014cta, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kurita","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kinki University School of Medicine , Higashi\u014dsaka, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiew-Hwa Katherine","family":"Teng","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore , Singapore ,","place":["Singapore"]},{"name":"School of Population Health, University of Western Australia , Perth, WA ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inder","family":"Anand","sequence":"additional","affiliation":[{"name":"VA Medical Center, University of Minnesota , Minneapolis, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn S.P.","family":"Lam","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore , Singapore ,","place":["Singapore"]},{"name":"Cardiovascular Research Institute, National University Heart Centre , Singapore ,","place":["Singapore"]},{"name":"Duke\u2013National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nippon Medical School , Bunky\u014d, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,21]]},"reference":[{"key":"2026012115115190900_ehf212228-bib-0001","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ejheart.2006.07.007","article-title":"International variations in the treatment and co-morbidity of left ventricular systolic dysfunction: data from the EuroHeart Failure Survey","volume":"9","author":"Lainscak","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2026012115115190900_ehf212228-bib-0002","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0002-9343(02)01346-3","article-title":"The effects of beta-blockers on morbidity and mortality in a 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