{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:25:23Z","timestamp":1793258723400,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2923,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1TR000058"],"award-info":[{"award-number":["UL1TR000058"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R34HL117026"],"award-info":[{"award-number":["1R34HL117026"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1TR000058"],"award-info":[{"award-number":["UL1TR000058"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R34HL117026"],"award-info":[{"award-number":["1R34HL117026"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that presents clinicians with a diagnostic challenge. The use of natriuretic peptides to exclude a diagnosis of HFpEF has been proposed. We sought to compare HFpEF patients with N-terminal pro-brain natriuretic peptide (NT-proBNP) level above and below the proposed cut-off.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Stable patients (n = 30) with left ventricular (LV) ejection fraction \u2265 50% were eligible if they had a diagnosis of HF according to the European Society of Cardiology diagnostic criteria. Characteristics of patients with NT-proBNP below (\u2264125 pg\/mL) and above (&amp;gt;125 pg\/mL) the diagnostic criterion were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 19 (66%) women with median age 54 years. Half were African American (16, 53%), and most were obese. There were no significant differences in clinical characteristics or medication use between groups. LV end-diastolic volume index was greater in high NT-proBNP patients (P = 0.03). Left atrial volume index, E\/e\u2032 ratio, and E\/e\u2032 ratio at peak exercise were not significantly different between NT-proBNP groups. Peak oxygen consumption (VO2), VO2 at ventilatory threshold, and ventilatory efficiency measures were impaired in all patients and were not significantly different between high and low NT-proBNP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NT-proBNP was below the proposed diagnostic cut-off point of 125 pg\/mL in half of this obese study cohort. Cardiac diastolic dysfunction and cardiorespiratory fitness were not significantly different between high and low NT-proBNP patients. These data indicate that excluding the diagnosis of HFpEF based solely on NT-proBNP levels should be discouraged.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12235","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:10:45Z","timestamp":1516234245000},"page":"372-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Low NT-proBNP Levels in Overweight and Obese Patients Do Not Rule Out a Diagnosis of Heart Failure with Preserved Ejection Fraction"],"prefix":"10.1093","volume":"5","author":[{"given":"Leo F.","family":"Buckley","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University , Richmond, VA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Canada","sequence":"additional","affiliation":[{"name":"VCU Pauley Heart Center, Virginia Commonwealth University , 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298 ,","place":["USA"]},{"name":"Department of Kinesiology and Health Sciences, Virginia Commonwealth University , Richmond, VA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco G.","family":"Del Buono","sequence":"additional","affiliation":[{"name":"VCU Pauley Heart Center, Virginia Commonwealth University , 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Carbone","sequence":"additional","affiliation":[{"name":"VCU Pauley Heart Center, Virginia Commonwealth University , 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298 ,","place":["USA"]},{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory R.","family":"Trankle","sequence":"additional","affiliation":[{"name":"VCU Pauley Heart Center, Virginia Commonwealth University , 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Billingsley","sequence":"additional","affiliation":[{"name":"VCU Pauley Heart Center, Virginia Commonwealth University , 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kadariya","sequence":"additional","affiliation":[{"name":"VCU Pauley Heart Center, Virginia Commonwealth University , 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Arena","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin W.","family":"Van Tassell","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University , Richmond, VA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Abbate","sequence":"additional","affiliation":[{"name":"VCU Pauley Heart Center, Virginia Commonwealth University , 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"2026012115120025000_ehf212235-bib-0001","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.CIR.0000053947.82595.03","article-title":"Heart failure with a normal ejection fraction: is it really a disorder of diastolic 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