{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:23:49Z","timestamp":1769088229567,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2979,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A patient presented with symptoms of decompensated heart failure 2 months after percutaneous mitral valve (MV) repair. Echocardiography demonstrated impaired left ventricular function with elevated MV pressure gradients and pulmonary pressures during rapid atrial fibrillation. Heart rate control was achieved by implantation of a biventricular pacemaker with subsequent His-bundle ablation because atrial fibrillation was refractory to medical treatment. During biventricular pacing at different rates (50\u2013110 b.p.m.), heart rate correlated positively with both MV mean pressure gradient and global longitudinal strain and negatively with stroke volume. MV pressure gradients directly translated into elevated pulmonary pressures. Thus, rate control and biventricular pacing improved cardiac haemodynamics.<\/jats:p>","DOI":"10.1002\/ehf2.12238","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T05:56:40Z","timestamp":1511416600000},"page":"193-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mitral Valve Pressure Gradient After Percutaneous Mitral Valve Repair: Every Beat Counts"],"prefix":"10.1093","volume":"5","author":[{"given":"Daniel","family":"Lavall","sequence":"first","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Klinik f\u00fcr Innere Medizin III \u2013 Kardiologie, Angiologie und internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes , D-66421, Homburg, Saar ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Scheller","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Klinik f\u00fcr Innere Medizin III \u2013 Kardiologie, Angiologie und internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes , D-66421, Homburg, Saar ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Werner","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Klinik f\u00fcr Innere Medizin III \u2013 Kardiologie, Angiologie und internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes , D-66421, Homburg, Saar ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Buob","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Klinik f\u00fcr Innere Medizin III \u2013 Kardiologie, Angiologie und internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes , D-66421, Homburg, Saar ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Universit\u00e4t des Saarlandes, Klinik f\u00fcr Innere Medizin III \u2013 Kardiologie, Angiologie und internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes , D-66421, Homburg, Saar ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"2026012115121145600_ehf212238-bib-0001","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.echo.2016.05.012","article-title":"Early hemodynamic improvement after percutaneous mitral valve repair evaluated by noninvasive pressure-volume analysis","volume":"29","author":"Lavall","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"2026012115121145600_ehf212238-bib-0002","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1161\/CIRCULATIONAHA.112.135061","article-title":"Real-time left ventricular pressure-volume loops during percutaneous mitral valve repair with the MitraClip system","volume":"127","author":"Gaemperli","year":"2013","journal-title":"Circulation"},{"key":"2026012115121145600_ehf212238-bib-0003","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/eurheartj\/ehv627","article-title":"One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry","volume":"37","author":"Puls","year":"2016","journal-title":"Eur Heart J"},{"key":"2026012115121145600_ehf212238-bib-0004","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2014.06.1166","article-title":"Percutaneous mitral valve edge-to-edge repair: in-hospital results and 1-year follow-up of 628 patients of the 2011-2012 Pilot European Sentinel Registry","volume":"64","author":"Nickenig","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2026012115121145600_ehf212238-bib-0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.amjcard.2015.10.044","article-title":"Comparison of percutaneous mitral valve repair versus conservative treatment in severe functional mitral regurgitation","volume":"117","author":"Giannini","year":"2016","journal-title":"Am J Cardiol"},{"key":"2026012115121145600_ehf212238-bib-0006","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1016\/j.jacc.2015.10.018","article-title":"Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST II","volume":"66","author":"Feldman","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2026012115121145600_ehf212238-bib-0007","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). 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