{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:40:20Z","timestamp":1769107220763,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2888,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Sleep-disordered breathing (SDB) is a highly prevalent co-morbidity in patients with chronic heart failure (CHF) and can play a detrimental role in the pathophysiology course of CHF. However, the best way to manage SDB in CHF remains a matter of debate. Sacubitril\u2013valsartan has been included in the 2016 European Society of Cardiology guidelines as an alternative to angiotensin-converting enzyme inhibitors to further reduce the risk of progression of CHF, CHF hospitalization, and death in ambulatory patients. Sacubitril and valsartan are good candidates for correcting SDB of CHF patients because their known mechanisms of action are likely to counteract the pathophysiology of SDB in CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The ENTRESTO-SAS trial is a 3-month, multicentric, prospective, open-label real-life cohort study. Patients eligible for sacubitril\u2013valsartan treatment (i.e. adults with left ventricular ejection fraction \u226435%, who remain symptomatic despite optimal treatment with an angiotensin-converting enzyme inhibitor, a beta-blocker, and a mineralocorticoid receptor antagonist) will be evaluated before and after 3 months of treatment (nocturnal ventilatory polygraphy, echocardiography, laboratory testing, and quality-of-life and SDB questionnaires). The primary outcome is the change in the Apnoea\u2013Hypopnoea Index, before and after 3 months of treatment. One hundred twenty patients are required to detect a significant 20% improvement of the Apnoea\u2013Hypopnoea Index with a power of 90% at an alpha risk of 5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the context of the SERVE-HF study, physicians are waiting for new trials and alternative therapies. We sought to assess in the ENTRESTO-SAS trial whether sacubitril\u2013valsartan could improve the outcome of SDB in CHF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12270","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T06:06:39Z","timestamp":1519279599000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impact of Sacubitril\u2013Valsartan Combination in Patients with Chronic Heart Failure and Sleep Apnoea Syndrome: The ENTRESTO-SAS Study Design"],"prefix":"10.1093","volume":"5","author":[{"given":"Dany","family":"Jaffuel","sequence":"first","affiliation":[{"name":"Department of Pneumology, Arnaud de Villeneuve, Regional University Hospital of Montpellier , 371 Avenue du Doyen Giraud, 34295, Montpellier Cedex 5 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Molinari","sequence":"additional","affiliation":[{"name":"Department of Medical Information, Montpellier University Hospital, IMAG UMR 5149, Montpellier University , 34090, Montpellier ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Berdague","sequence":"additional","affiliation":[{"name":"Department of Cardiology, B\u00e9ziers Hospital , 2 rue Valentin Ha\u00fby, BP 740, 34525, B\u00e9ziers Cedex ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hypertension and Heart Failure Unit, Health Innovation Laboratory , Clinique Pasteur, Avenue de Lombez, 31000, Toulouse ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Galinier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Rangueil , 1, Avenue Professeur Jean Poulh\u00e8s, 31095, Toulouse ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Respiratory Tracts Center, H\u00f4pital Larrey , 24, chemin de Pouvourville, TSA 30030, 31059, Toulouse Cedex 9 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Etienne","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Caremeau , Place du Pr Robert Debr\u00e9, 30029, Nimes Cedex 9 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Mallet","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Arnaud de Villeneuve, Regional University Hospital of Montpellier , 371 Avenue du Doyen Giraud, 34295, Montpellier Cedex 5 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Bourdin","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Arnaud de Villeneuve, Regional University Hospital of Montpellier , 371 Avenue du Doyen Giraud, 34295, Montpellier Cedex 5 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Regional University Hospital of Montpellier, PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR , 9214, Montpellier ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"2026012115113753100_ehf212270-bib-0001","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/heart.83.5.596","article-title":"Epidemiology, aetiology, and prognosis of heart failure","volume":"83","author":"McMurray","year":"2000","journal-title":"Heart"},{"key":"2026012115113753100_ehf212270-bib-0002","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/hrt.2003.025270","article-title":"Clinical epidemiology of heart failure","volume":"93","author":"Mosterd","year":"2007","journal-title":"Heart"},{"key":"2026012115113753100_ehf212270-bib-0003","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","article-title":"ESC Committee for Practice Guidelines. 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