{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:46:46Z","timestamp":1790221606922,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2807,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H26-Ippan-001"],"award-info":[{"award-number":["H26-Ippan-001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H26\u2010Ippan\u2010001"],"award-info":[{"award-number":["H26\u2010Ippan\u2010001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Patients with fulminant myocarditis (FM) often present with cardiogenic shock and require mechanical circulatory support, including extracorporeal membrane oxygenation (ECMO) and ventricular assist device (VAD) implantation. This study sought to clarify the determinants of successful weaning from ECMO in FM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We studied 37 consecutive FM patients supported by ECMO as the initial form of mechanical circulatory support between January 1995 and December 2014 in our hospital. Twenty-two (59%) patients were successfully weaned from ECMO, while 15 (41%) were not. There were significant differences in levels of peak creatine kinase and those of its MB isoform (CK-MB), left ventricular posterior wall thickness (LVPWT), and prevalence of cardiac rhythm disturbances. Receiver operating characteristic curve analysis revealed that a peak CK-MB level of 185 IU\/L and LVPWT of 11 mm were the optimal cut-off values for predicting successful weaning from ECMO (areas under the curve, 0.89 and 0.85, respectively). During the follow-up [median 48 (interquartile range 8\u2013147) months], 83% of FM patients who were weaned from ECMO survived, with preserved fractional shortening based on echocardiography. Of the 15 FM patients who were not weaned from ECMO, nine bridged to VAD, and only two were successfully weaned from VAD and survived.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that myocardial injury, as evidenced by CK-MB and LVPWT, and prolonged presence of cardiac rhythm disturbances are important clinical determinants of successful weaning from ECMO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12291","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T10:30:33Z","timestamp":1526293833000},"page":"675-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Clinical Determinants of Successful Weaning from Extracorporeal Membrane Oxygenation in Patients with Fulminant Myocarditis"],"prefix":"10.1093","volume":"5","author":[{"given":"Manabu","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]},{"name":"Department of Innovative Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai, Miyagi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Asaumi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Department of Transplantation, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Kanaya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Transplantation, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Seguchi","sequence":"additional","affiliation":[{"name":"Department of Transplantation, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Yanase","sequence":"additional","affiliation":[{"name":"Department of Transplantation, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Anzai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatsue","family":"Ishibashi-Ueda","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai, Miyagi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center , Suita, Osaka ,","place":["Japan"]},{"name":"Department of Innovative Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai, Miyagi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"2026012115112569800_ehf212291-bib-0001","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ncpcardio1331","article-title":"Fulminant myocarditis","volume":"5","author":"Gupta","year":"2008","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"2026012115112569800_ehf212291-bib-0002","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1056\/NEJM200003093421003","article-title":"Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis","volume":"342","author":"McCarthy","year":"2000","journal-title":"New Engl J Med"},{"key":"2026012115112569800_ehf212291-bib-0003","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.healun.2003.09.038","article-title":"Myocarditis with shock: what mechanical support should be considered first?","volume":"24","author":"Chen","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"2026012115112569800_ehf212291-bib-0004","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1093\/eurheartj\/ehi411","article-title":"Favourable clinical outcome in patients with cardiogenic shock due to fulminant myocarditis supported by percutaneous extracorporeal membrane oxygenation","volume":"26","author":"Asaumi","year":"2005","journal-title":"Eur Heart J"},{"key":"2026012115112569800_ehf212291-bib-0005","first-page":"682","article-title":"Extracorporeal membranous oxygenation support for acute fulminant myocarditis: analysis of a single center's experience","volume":"40","author":"Hsu","year":"2011","journal-title":"Eur J Cardiothoracic Surg"},{"key":"2026012115112569800_ehf212291-bib-0006","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/ejcts\/ezs242","article-title":"Rapid onset of fulminant myocarditis portends a favourable prognosis and the ability to bridge mechanical circulatory support to recovery","volume":"43","author":"Atluri","year":"2013","journal-title":"Eur J Cardiothoracic Surg"},{"key":"2026012115112569800_ehf212291-bib-0007","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/CIRCULATIONAHA.109.858076","article-title":"Selection of cardiac transplantation candidates in 2010","volume":"122","author":"Mancini","year":"2010","journal-title":"Circulation"},{"key":"2026012115112569800_ehf212291-bib-0008","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1253\/circj.CJ-14-0970","article-title":"The Registry Report of Heart Transplantation in Japan (1999\u20132013)","volume":"78","author":"Nakatani","year":"2014","journal-title":"Circ J"},{"key":"2026012115112569800_ehf212291-bib-0009","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.athoracsur.2015.08.014","article-title":"Venoarterial extracorporeal membrane oxygenation for acute fulminant myocarditis in adult patients: a 5-year multi-institutional experience","volume":"101","author":"Lorusso","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"2026012115112569800_ehf212291-bib-0010","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1097\/CCM.0000000000000920","article-title":"Extracorporeal membrane oxygenation for the support of adults with acute myocarditis","volume":"43","author":"Diddle","year":"2015","journal-title":"Crit Care Med"},{"key":"2026012115112569800_ehf212291-bib-0011","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1093\/eurheartj\/ehv194","article-title":"Predicting survival after ECMO for refractory cardiogenic shock: the survival after veno-arterial-ECMO (SAVE)-score","volume":"36","author":"Schmidt","year":"2015","journal-title":"Eur Heart J"},{"key":"2026012115112569800_ehf212291-bib-0012","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1253\/jcj.65.145","article-title":"Appropriate indications for the use of a percutaneous cardiopulmonary support system in cases with cardiogenic shock complicating acute myocardial infarction","volume":"65","author":"Aiba","year":"2001","journal-title":"Circ J"},{"key":"2026012115112569800_ehf212291-bib-0013","first-page":"M420","article-title":"Practical assessment of natural heart function using echocardiography in mechanically assisted patients","volume":"37","author":"Nakatani","year":"1991","journal-title":"ASAIO Trans"},{"key":"2026012115112569800_ehf212291-bib-0014","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10047-009-0448-5","article-title":"Fifteen-year experience with Toyobo paracorporeal left ventricular assist system","volume":"12","author":"Saito","year":"2009","journal-title":"J Artifi Organs"},{"key":"2026012115112569800_ehf212291-bib-0015","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1253\/circj.CJ-11-0833","article-title":"Initial experience of conversion of Toyobo paracorporeal left ventricular assist device to DuraHeart left ventricular assist device","volume":"76","author":"Yoshioka","year":"2012","journal-title":"Circ J"},{"key":"2026012115112569800_ehf212291-bib-0016","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.amjcard.2013.10.021","article-title":"In-hospital arrhythmia development and outcomes in pediatric patients with acute myocarditis","volume":"113","author":"Miyake","year":"2014","journal-title":"Am J of Cardiol"},{"key":"2026012115112569800_ehf212291-bib-0017","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0046-8177(87)80363-5","article-title":"Myocarditis: the Dallas criteria","volume":"18","author":"Aretz","year":"1987","journal-title":"Hum Pathol"},{"key":"2026012115112569800_ehf212291-bib-0018","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.jacc.2015.02.043","article-title":"2015 SCAI\/ACC\/HFSA\/STS clinical expert consensus statement on the use of percutaneous mechanical circulatory support devices in cardiovascular care: endorsed by the American Heart Association, the Cardiological Society of India, and Sociedad Latino Americana de Cardiologia Intervencionista; Affirmation of value by the Canadian Association of Interventional Cardiology-Association Canadienne de Cardiologie d'intervention","volume":"65","author":"Rihal","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2026012115112569800_ehf212291-bib-0019","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cardfail.2014.03.005","article-title":"Clinical outcomes in fulminant myocarditis requiring extracorporeal membrane oxygenation: a weighted meta-analysis of 170 patients","volume":"20","author":"Cheng","year":"2014","journal-title":"J Card Fail"},{"key":"2026012115112569800_ehf212291-bib-0020","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jtcvs.2008.09.051","article-title":"Paracorporeal pulsatile biventricular assist device versus extracorporal membrane oxygenation-extracorporal life support in adult fulminant myocarditis","volume":"137","author":"Pages","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026012115112569800_ehf212291-bib-0021","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/S0003-4975(00)02628-X","article-title":"Mechanical circulatory support for patients with acute-fulminant myocarditis","volume":"71","author":"Acker","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"2026012115112569800_ehf212291-bib-0022","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00595-007-3724-0","article-title":"Mechanical circulatory support for fulminant myocarditis","volume":"38","author":"Sezai","year":"2008","journal-title":"Surg Today"},{"key":"2026012115112569800_ehf212291-bib-0023","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.pathmechdis.3.121806.151534","article-title":"Molecular biology and pathogenesis of viral myocarditis","volume":"3","author":"Esfandiarei","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"2026012115112569800_ehf212291-bib-0024","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jacc.2004.01.055","article-title":"Serum levels of interleukin-10 on admission as a prognostic predictor of human fulminant myocarditis","volume":"44","author":"Nishii","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2026012115112569800_ehf212291-bib-0025","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1161\/CIRCULATIONAHA.113.003092","article-title":"Long-term evolution and prognostic stratification of biopsy-proven active myocarditis","volume":"128","author":"Anzini","year":"2013","journal-title":"Circulation"},{"key":"2026012115112569800_ehf212291-bib-0026","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/01.CIR.89.1.252","article-title":"Gamma-globulin treatment of acute myocarditis in the pediatric population","volume":"89","author":"Drucker","year":"1994","journal-title":"Circulation"},{"key":"2026012115112569800_ehf212291-bib-0027","doi-asserted-by":"crossref","first-page":"e751","DOI":"10.1097\/CCM.0000000000001654","article-title":"Treating life-threatening myocarditis by blocking interleukin-1","volume":"44","author":"Cavalli","year":"2016","journal-title":"Crit Care Med"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fehf2.12291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/5\/4\/675\/66137111\/eschf_5_4_675.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/5\/4\/675\/66137111\/eschf_5_4_675.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:14:58Z","timestamp":1769026498000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/5\/4\/675\/8403780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,5,14]]},"published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.12291","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8]]},"published":{"date-parts":[[2018,5,14]]},"assertion":[{"value":"2017-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}