{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:04:03Z","timestamp":1777442643280,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2765,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Recent guidelines recommend cardiac resynchronization therapy (CRT) in mildly symptomatic heart failure (HF) but favour left bundle branch block (LBBB) morphology in patients with moderate QRS prolongation (120\u2013150 ms). We defined how many patients hospitalized with HF fulfil these criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A single-centre retrospective cohort study of 363 consecutive patients hospitalized with HF (438 admissions) was performed. Electronic imaging, electrocardiograms, and records were reviewed. Overall, 153 patients (42%) had left ventricular ejection fraction (LVEF) \u2264 35%, and 34% of patients had QRS prolongation. Eighty patients (22%) were potentially eligible with LVEF \u2264 35% and QRS \u2265 120 ms or existing CRT. The majority (68 of 80) had a Class I or IIa recommendation according to international guidelines (LBBB or non-LBBB QRS \u2265 150 ms or right ventricular pacing). Only a minority (12 of 80) had moderate QRS prolongation of non-LBBB morphology. One-quarter (n = 22) of patients fulfilling criteria were ineligible for reasons including dementia, co-morbidities, or palliative care. A further eight patients required optimization of medical therapy. CRT was therefore immediately indicated in 50 patients. Of these, 29 were implanted or had existing CRT systems. Twenty-one of the 80 patients eligible for CRT were not identified or treated (6% of the total hospitalized cohort).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Twenty-two per cent of elderly real-life patients hospitalized with HF fulfil LVEF and QRS criteria for CRT, most having a Class I or IIa indication. However, a large proportion is ineligible owing to co-morbidities or requires medical optimization. Although uptake of CRT was reasonable, there remain opportunities for improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12297","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T08:07:55Z","timestamp":1529914075000},"page":"668-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Eligibility for Cardiac Resynchronization Therapy in Patients Hospitalized with Heart Failure"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-0838","authenticated-orcid":false,"given":"Joanna","family":"Osmanska","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel M.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of British Columbia , Vancouver, BC ,","place":["Canada"]},{"name":"Vancouver General Hospital , Vancouver, BC ,","place":["Canada"]},{"name":"BC Centre for Improved Cardiovascular Health, St. Paul's Hospital , 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Toma","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of British Columbia , Vancouver, BC ,","place":["Canada"]},{"name":"Vancouver General Hospital , Vancouver, BC ,","place":["Canada"]},{"name":"BC Centre for Improved Cardiovascular Health, St. Paul's Hospital , 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ignaszewski","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of British Columbia , Vancouver, BC ,","place":["Canada"]},{"name":"Vancouver General Hospital , Vancouver, BC ,","place":["Canada"]},{"name":"BC Centre for Improved Cardiovascular Health, St. Paul's Hospital , 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean A.","family":"Virani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of British Columbia , Vancouver, BC ,","place":["Canada"]},{"name":"Vancouver General Hospital , Vancouver, BC ,","place":["Canada"]},{"name":"BC Centre for Improved Cardiovascular Health, St. Paul's Hospital , 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"2026012115113496500_ehf212297-bib-0001","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1093\/eurheartj\/ehm305","article-title":"Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. 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