{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:32:48Z","timestamp":1771054368711,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2730,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Functional mitral regurgitation is complicating end-stage heart failure and potential heart transplantation by increasing pulmonary artery pressures. The aim of the present study was to investigate feasibility and haemodynamic effects of percutaneous mitral valve edge-to-edge repair using the MitraClip\u2122 device in patients with end-stage heart failure awaiting heart transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this retrospective study, we identified nine patients suffering from end-stage heart failure listed for heart transplantation in whom moderate\u2013severe or severe functional mitral regurgitation was recognized and treated with percutaneous mitral valve edge-to-edge repair. Twenty-two patients listed for heart transplantation and presenting with moderate\u2013severe or severe functional mitral regurgitation treated in the pre-MitraClip\u2122 era served as controls. Patients were analysed at two separate time points: MitraClip\u2122 group: pre-procedure and post-procedure (follow-up: 215 \u00b1 53 days) and control group: study entry with recognition of moderate\u2013severe or severe functional mitral regurgitation (follow-up: 197 \u00b1 47 days). Percutaneous mitral valve edge-to-edge repair with the MitraClip\u2122 was feasible and safe in our high-risk end-stage heart failure population. The intervention resulted in significant reduction of mitral regurgitation (grade 3.0 [0.5] to 1.5 [0.5]; P = 0.009), left atrial diameter (51 mm [16] to 49 mm [4]; follow-up MitraClip\u2122 vs. control group P = 0.0497), pulmonary artery pressures (sPA 50 mmHg [15] to 45 mmHg [10]; P = 0.02; mPA 34 mmHg [8] to 30 mmHg [10]; P = 0.02), and New York Heart Association class (3.5 [1.0] to 3.0 [0.5]; P = 0.01) and improved mixed-venous oxygen saturation (57% [11] to 55% [7]; follow-up MitraClip\u2122 vs. control group P = 0.02). No changes in the control group were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MitraClip\u2122 implantation as \u2018bridge-to-transplant\u2019 strategy in patients with end-stage heart failure and severe functional mitral regurgitation awaiting heart transplantation is feasible and appears to result in favourable haemodynamic effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12313","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T07:10:40Z","timestamp":1532934640000},"page":"892-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Haemodynamic Effects of Percutaneous Mitral Valve Edge-to-Edge Repair in Patients with End-Stage Heart Failure Awaiting Heart Transplantation"],"prefix":"10.1093","volume":"5","author":[{"given":"Nicolas A.","family":"Geis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, University of Heidelberg , Im Neuenheimer Feld 410, 69120, Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven T.","family":"Pleger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, University of Heidelberg , Im Neuenheimer Feld 410, 69120, Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffi","family":"Bekeredjian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, University of Heidelberg , Im Neuenheimer Feld 410, 69120, Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Chorianopoulos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, University of Heidelberg , Im Neuenheimer Feld 410, 69120, Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Kreusser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, University of Heidelberg , Im Neuenheimer Feld 410, 69120, Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Frankenstein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, University of Heidelberg , Im Neuenheimer Feld 410, 69120, Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjang","family":"Ruhparwar","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, University of Heidelberg , Im Neuenheimer Feld 410, 69120, Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip W.J.","family":"Raake","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Cardiology, University of Heidelberg , Im Neuenheimer Feld 410, 69120, Heidelberg 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