{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:51:15Z","timestamp":1781074275272,"version":"3.54.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2751,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation (BHF) project grant","doi-asserted-by":"publisher","award":["CS\/15\/3\/31405"],"award-info":[{"award-number":["CS\/15\/3\/31405"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"British Heart Foundation (BHF) project grant","award":["CS\/15\/3\/31405"],"award-info":[{"award-number":["CS\/15\/3\/31405"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In patients with heart failure and a pathologically prolonged PR interval, left ventricular (LV) filling can be improved by shortening atrioventricular delay using His-bundle pacing. His-bundle pacing delivers physiological ventricular activation and has been shown to improve acute haemodynamic function in this group of patients.<\/jats:p>\n                    <jats:p>In the HOPE-HF (His Optimized Pacing Evaluated for Heart Failure) trial, we are investigating whether these acute haemodynamic improvements translate into improvements in exercise capacity and heart failure symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This multicentre, double-blind, randomized, crossover study aims to randomize 160 patients with PR prolongation (\u2265200 ms), LV impairment (EF \u2264 40%), and either narrow QRS (\u2264140 ms) or right bundle branch block. All patients receive a cardiac device with leads positioned in the right atrium and the His bundle. Eligible patients also receive a defibrillator lead. Those not eligible for implantable cardioverter defibrillator have a backup pacing lead positioned in an LV branch of the coronary sinus. Patients are allocated in random order to 6 months of (i) haemodynamically optimized dual chamber His-bundle pacing and (ii) backup pacing only, using the non-His ventricular lead.<\/jats:p>\n                    <jats:p>The primary endpoint is change in exercise capacity assessed by peak oxygen uptake. Secondary endpoints include change in ejection fraction, quality of life scores, B-type natriuretic peptide, daily patient activity levels, and safety and feasibility assessments of His-bundle pacing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hope-HF aims to determine whether correcting PR prolongation in patients with heart failure and narrow QRS or right bundle branch block using haemodynamically optimized dual chamber His-bundle pacing improves exercise capacity and symptoms. We aim to complete recruitment by the end of 2018 and report in 2020.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12315","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T05:29:00Z","timestamp":1531114140000},"page":"965-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Rationale and Design of the Randomized Multicentre His Optimized Pacing Evaluated for Heart Failure (HOPE-HF) Trial"],"prefix":"10.1093","volume":"5","author":[{"given":"Daniel","family":"Keene","sequence":"first","affiliation":[{"name":"Imperial College London , London ,","place":["UK"]},{"name":"Imperial College Healthcare NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahran","family":"Arnold","sequence":"additional","affiliation":[{"name":"Imperial College London , London ,","place":["UK"]},{"name":"Imperial College Healthcare NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Shun-Shin","sequence":"additional","affiliation":[{"name":"Imperial College London , London ,","place":["UK"]},{"name":"Imperial College Healthcare NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Howard","sequence":"additional","affiliation":[{"name":"Imperial College London , London ,","place":["UK"]},{"name":"Imperial College Healthcare NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SM Afzal","family":"Sohaib","sequence":"additional","affiliation":[{"name":"Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Moore","sequence":"additional","affiliation":[{"name":"West Hertfordshire Hospitals NHS Trust , Hertfordshire ,","place":["UK"]},{"name":"Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tanner","sequence":"additional","affiliation":[{"name":"West Sussex Hospitals NHS Trust , West Sussex ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Quereshi","sequence":"additional","affiliation":[{"name":"Wycombe General Hospital , High Wycombe ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Muthumala","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust , London ,","place":["UK"]},{"name":"North Middlesex University Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badrinathan","family":"Chandresekeran","sequence":"additional","affiliation":[{"name":"Great Western Hospitals NHS Foundation Trust , Swindon ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Foley","sequence":"additional","affiliation":[{"name":"Great Western Hospitals NHS Foundation Trust , Swindon ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Leyva","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham , Birmingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaumik","family":"Adhya","sequence":"additional","affiliation":[{"name":"Medway NHS Foundation Trust , Kent ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Falaschetti","sequence":"additional","affiliation":[{"name":"Imperial College Trials Unit, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Tsang","sequence":"additional","affiliation":[{"name":"Imperial College Trials Unit, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pugal","family":"Vijayaraman","sequence":"additional","affiliation":[{"name":"Geisinger Commonwealth School of Medicine, Geisinger Heart Institute , Scranton, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[{"name":"Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Stegemann","sequence":"additional","affiliation":[{"name":"Bakken Research Center B.V. 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