{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:15:20Z","timestamp":1787318120089,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2743,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Acute cardiorenal syndrome (CRS) with and without consideration of the volume state was assessed with regard to inflammatory parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Blood samples from patients with acute CRS (Ronco type 1 or 3, Group 1, n = 15), end-stage renal disease (Group 2, n = 12), hypertension (Group 3, n = 15), and, in a second cohort, with acute CRS and hypervolemia (Group 4, n = 9) and hypertension (Group 5, n = 10) were analysed with regard to lipopolysaccharide-binding protein (LBP), interleukins (ILs), and monocyte function (flow cytometry) both on admission (all groups) and on discharge (Groups 1 and 4). By discharge, one Group 1 patient died. LBP (ANOVA for Groups 1\u20133: P = 0.001) and IL-6 (Kruskal\u2013Wallis for Groups 1\u20133: P &amp;lt; 0.0001) were higher in Group 1 (LBP: 11.7 \u00b1 2.0 \u03bcg\/mL; IL-6: 15.0 \u00b1 6.1 pg\/mL) and in Group 2 (LBP: 10.4 \u00b1 1.4 \u03bcg\/mL; IL-6: 14.6 \u00b1 3.8 pg\/mL) than in Group 3 (LBP: 5.8 \u00b1 0.4 \u03bcg\/mL; IL-6: 1.8 \u00b1 0.4 pg\/mL). In a direct comparison, the proportion of activated monocytes (CD14 and CD16 positive) was higher in Group 1 (6.9% \u00b1 0.7%) vs. Group 3 (5.1% \u00b1 0.6%; P = 0.018). Group 4 patients had higher IL-6 plasma levels (34.2 \u00b1 10.1 pg\/mL) than Group 1 patients (15.0 \u00b1 6.1 pg\/mL; P = 0.03). All other findings obtained in CRS groups (Groups 1 and 4) were comparable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In acute CRS, a state of systemic inflammation was found, which is comparable with the end-stage renal disease situation. In comparison with hypertensive controls, a monocytic activation was found in acute CRS regardless of volume state.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12327","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T06:58:55Z","timestamp":1531810735000},"page":"920-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Systemic Inflammation in Acute Cardiorenal Syndrome: An Observational Pilot Study"],"prefix":"10.1093","volume":"5","author":[{"given":"Christoph","family":"Linhart","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, Martin Luther University Halle-Wittenberg , Halle ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Martin Luther University Halle-Wittenberg , Halle ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Greinert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Martin Luther University Halle-Wittenberg , Halle ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Dambeck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Martin Luther University Halle-Wittenberg , Halle ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wienke","sequence":"additional","affiliation":[{"name":"Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin Luther University Halle-Wittenberg , Halle ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Girndt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Martin Luther 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