{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:03:12Z","timestamp":1769122992335,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2695,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bayer Pharma"},{"DOI":"10.13039\/100004319","name":"BMS\/Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boehringer Ingelheim International"},{"name":"Boston Scientific International"},{"DOI":"10.13039\/501100022274","name":"Daiichi Sankyo Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Laboratoires Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Menarini International"},{"name":"MSD\/Merck & Co"},{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sanofi-Aventis Group"},{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This analysis evaluates gender differences in the Egyptian cohort of patients hospitalized for acute heart failure (AHF) in the European Society of Cardiology Heart Failure Long-Term Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>From April 2011 to September 2014, 1634 patients hospitalized with AHF were enrolled by 20 hospitals all over Egypt. Of these patients, 1112 (68%) patients were male and 522 (32%) were female. Women presented with a higher admission systolic blood pressure and resting heart rate. Compared with men, women had a higher body mass index (32.5 \u00b1 9.0 vs. 29.3 \u00b1 4.9, P &amp;lt; 0.001), more frequent atrial fibrillation (34.7% vs. 22.4%, P &amp;lt; 0.001), and anaemia defined by haemoglobin &amp;lt; 12 g\/dL (83.1% vs. 58.4%, P &amp;lt; 0.001). Women were more likely to present with heart failure with preserved ejection fraction (29.7% vs. 10.6%, P &amp;lt; 0.001). Women had more frequent diabetes mellitus (48.1% vs. 41.6%, P &amp;lt; 0.05) and hypertension (48.7% vs. 39.3%, P &amp;lt; 0.001) than had men, whereas smoking was rare among them (8.8% vs. 82.9%, P &amp;lt; 0.005). There was no significant difference in the primary aetiology of heart failure between both sexes. ACE inhibitors, beta-blockers, mineralocorticoid receptor antagonists, antiplatelets, statins, and nitrates were less frequently prescribed to women, whereas they more often received digoxin, amiodarone, anticoagulants, and calcium channel blockers. There was no significant difference in in-hospital (5.7% vs. 4.6%, P = 0.39) and 1 year mortality (27.9% vs. 25.9%, P = 0.48) between women and men, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Men and women with AHF differ significantly in baseline clinical characteristics and management but not in adverse outcomes. These findings emphasize the importance of individualized management and need for more comprehensive recruitment of women in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12347","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T08:06:32Z","timestamp":1535961992000},"page":"1159-1164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Gender Differences in Egyptian Patients Hospitalized with Heart Failure: Insights from the European Society of Cardiology Heart Failure Long-Term Registry"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-8371","authenticated-orcid":false,"given":"Mahmoud","family":"Hassanein","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Alexandria University , Champillion Street, Azarita, Alexandria ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdy","family":"Abdelhamid","sequence":"additional","affiliation":[{"name":"Kasr Al Ainy Hospital, Cairo University , Cairo ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"National Heart Institute , Imbaba, Giza ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Sobhy","sequence":"additional","affiliation":[{"name":"International Cardiac Centre , Alexandria ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamela","family":"Nasr","sequence":"additional","affiliation":[{"name":"Ismaileya Insurance Hospital , Ismaileya ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Wafaie","family":"Aboleineen","sequence":"additional","affiliation":[{"name":"Zagazig University , Zagazig ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Reda","sequence":"additional","affiliation":[{"name":"Menoufia University , Shibin El Kom ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Farag","sequence":"additional","affiliation":[{"name":"Dar Al Fouad Hospital , Cairo ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Elshazly","sequence":"additional","affiliation":[{"name":"Gamal Abdel Nasser Insurance Hospital , Alexandria ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek Khairy","family":"Abdeldayem","sequence":"additional","affiliation":[{"name":"Ain Shams University , Cairo ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Elmesseiry","sequence":"additional","affiliation":[{"name":"Ras Eltin General Hospital , Alexandria ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"Boshra","sequence":"additional","affiliation":[{"name":"Beni Suef University , Beni Suef ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"Sobhy","sequence":"additional","affiliation":[{"name":"El Menshawy General Hospital , Tanta ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atef","family":"Elbahry","sequence":"additional","affiliation":[{"name":"Port Fouad General Hospital , Port Fouad ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Youssef","sequence":"additional","affiliation":[{"name":"Assiut University , Assiut ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medhat","family":"Ashmawy","sequence":"additional","affiliation":[{"name":"Tanta University , Tanta 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