{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:33:19Z","timestamp":1769088799231,"version":"3.49.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2674,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PHARIS Biotec GmbH"},{"name":"PHARIS Biotec GmbH"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Acute decompensated heart failure (ADHF) has a poor prognosis and limited treatment options. No direct comparisons between ularitide\u2014a synthetic natriuretic peptide being evaluated in ADHF\u2014and other vasoactive substances are available. The aim of this meta-analysis was to determine haemodynamic effect sizes from randomized double-blind trials in ADHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Eligible studies enrolled patients with ADHF requiring hospitalization and haemodynamic monitoring. Patients received 24\u201348 h of infusion with a vasoactive substance or comparator. Primary outcome measure was pulmonary artery wedge pressure (PAWP). Treatment effects were quantified as changes from baseline using mean differences between study drug and comparator. Results were analysed using random-effects (primary analysis) and fixed-effects meta-analyses. Twelve randomized, double-blind studies were identified with data after 3, 6, and 24 h of treatment (n = 622, 644, and 644, respectively). At 6 h, significant PAWP benefits for ularitide over placebo were seen (Hedges' g effect size, \u22120.979; P &amp;lt; 0.0001). On meta-analysis, treatment difference between ularitide and pooled other agents was statistically significant (\u22120.501; P = 0.0303). Effect sizes were numerically higher with ularitide than other treatments at 3 and 24 h. After 6 h, a significant difference in effect size between ularitide and all other treatments was observed for right atrial pressure (Hedges' g, \u22120.797 for ularitide and \u22120.304 for other treatments; P = 0.0274).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After 6 h, ularitide demonstrated high effect sizes for PAWP and right atrial pressure. Improvements in these parameters were greater with ularitide vs. pooled data for other vasoactive drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12349","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T06:11:41Z","timestamp":1537769501000},"page":"1023-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Randomized Double-Blind Clinical Studies of Ularitide and Other Vasoactive Substances in Acute Decompensated Heart Failure: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"5","author":[{"given":"Veselin","family":"Mitrovic","sequence":"first","affiliation":[{"name":"Kerckhoff-Klinik Forschungsgesellschaft mbH , K\u00fcchlerstrasse 10, 61231, Bad Nauheim ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf-Georg","family":"Forssmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic of Immunology, Division of Peptide Research, Hannover Medical School (MHH) , Hannover ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Schnitker","sequence":"additional","affiliation":[{"name":"Institute of Applied Statistics (IAS) Ltd , Bielefeld ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan B.","family":"Felix","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B, University Medicine Greifswald and DZHK (German Centre for Cardiovascular Research), partner site Greifswald , Greifswald ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"2026012115111423100_ehf212349-bib-0001","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1093\/eurheartj\/ehl337","article-title":"Haemodynamic and clinical effects of ularitide in decompensated heart failure","volume":"27","author":"Mitrovic","year":"2006","journal-title":"Eur Heart J"},{"key":"2026012115111423100_ehf212349-bib-0002","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.amjcard.2013.10.032","article-title":"Incidence and survival of hospitalized acute decompensated heart failure in four US communities (from the Atherosclerosis Risk in Communities Study)","volume":"113","author":"Chang","year":"2014","journal-title":"Am J Cardiol"},{"key":"2026012115111423100_ehf212349-bib-0003","first-page":"284","article-title":"Management of patients admitted with acute decompensated heart failure","volume":"15","author":"Krim","year":"2015","journal-title":"Ochsner J"},{"key":"2026012115111423100_ehf212349-bib-0004","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1001\/jama.287.12.1541","article-title":"Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial","volume":"287","author":"Cuffe","year":"2002","journal-title":"JAMA"},{"key":"2026012115111423100_ehf212349-bib-0005","doi-asserted-by":"crossref","first-page":"29060","DOI":"10.3390\/ijms161226147","article-title":"Use of inotropic agents in treatment of systolic heart failure","volume":"16","author":"Tariq","year":"2015","journal-title":"Int J Mol Sci"},{"key":"2026012115111423100_ehf212349-bib-0006","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1056\/NEJM199111213252103","article-title":"Effect of oral milrinone on mortality in severe chronic heart failure. 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