{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:26:37Z","timestamp":1771007197672,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2492,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Fibroblast growth factor 23 (FGF-23) is known to be elevated in patients with congestive heart failure (CHF). As FGF-23 is expressed in the bone but can also be expressed in the myocardium, the origin of serum FGF-23 in CHF remains unclear. It is also unclear if FGF-23 expressed in the bone is associated with outcome in CHF. The aim of the present study was to investigate FGF-23 levels measured in bone marrow plasma (FGF-23-BM) and in peripheral blood (FGF-23-P) in CHF patients to gain further insights into the heart\u2013bone axis of FGF-23 expression. We also investigated possible associations between FGF-23-BM as well as FGF-23-P and outcome in CHF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We determined FGF-23-P and FGF-23-BM levels in 203 CHF patients (85% male, mean age 61.3 years) with a left ventricular ejection fraction (LVEF) \u226445% and compared them with those of 48 healthy controls (48% male, mean age 39.2 years). We investigated the association between FGF-23-BM and FGF-23-P with all-cause mortality in CHF patients, 32 events, median follow-up 1673 days, interquartile range [923, 1828]. FGF-23-P (median 60.3 vs. 22.0 RU\/mL, P &amp;lt; 0.001) and FGF-23-BM (median 130.7 vs. 93.1 RU\/mL, P &amp;lt; 0.001) levels were higher in CHF patients compared with healthy controls. FGF-23-BM levels were significantly higher than FGF-23-P levels in both CHF patients and in healthy controls (P &amp;lt; 0.001). FGF-23-P and FGF-23-BM correlated significantly with LVEF (r = \u22120.37 and r = \u22120.33, respectively), N terminal pro brain natriuretic peptide levels (r = 0.57 and r = 0.6, respectively), New York Heart Association status (r = 0.28 and r = 0.25, respectively), and estimated glomerular filtration rate (r = \u22120.43 and r = \u22120.41, respectively) (P for all &amp;lt;0.001) and were independently associated with all-cause mortality in CHF patients after adjustment for LVEF, estimated glomerular filtration rate, New York Heart Association status, and N terminal pro brain natriuretic peptide, hazard ratio 2.71 [confidence interval: 1.18\u20136.20], P = 0.018, and hazard ratio 2.80 [confidence interval: 1.19\u20136.57], P = 0.018, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CHF patients, FGF-23 is elevated in bone marrow plasma and is independently associated with heart failure severity and all-cause mortality. The failing heart seems to interact via FGF-23 within a heart\u2013bone axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12416","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T01:40:41Z","timestamp":1553564441000},"page":"536-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Bone Marrow and Plasma FGF-23 in Heart Failure Patients: Novel Insights Into the Heart\u2013Bone Axis"],"prefix":"10.1093","volume":"6","author":[{"given":"Beatrice","family":"von Jeinsen","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"Department of Cardiology, Kerckhoff Heart and Thorax Center , Benekestr. 2-8, 61231, Bad Nauheim ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site RheinMain , Frankfurt 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Charit\u00e9 \u2013 Universitaetsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Fichtlscherer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site RheinMain , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian H.","family":"Seeger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site RheinMain , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Honold","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site RheinMain , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Dimmeler","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site RheinMain , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"A\u00dfmus","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site RheinMain , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas M.","family":"Zeiher","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), partner site RheinMain , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-6491","authenticated-orcid":false,"given":"Till","family":"Keller","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"Department of Cardiology, Kerckhoff Heart and Thorax Center , Benekestr. 2-8, 61231, Bad Nauheim 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