{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:31:32Z","timestamp":1793637092915,"version":"4.5.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":2514,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ek0210009h0003"],"award-info":[{"award-number":["15ek0210009h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ek0210009h0003"],"award-info":[{"award-number":["15ek0210009h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>There are regional differences in the patient characteristics, management, and outcomes of hospitalized patients with heart failure (HF). The aim of this study was to evaluate the clinical characteristics and outcomes of Japanese patients who are hospitalized with HF on the basis of the left ventricular ejection fraction (LVEF) stratum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively conducted a multicentre cohort study of 1245 hospitalized patients with decompensated HF between 2013 and 2014. Of these patients, 36% had an LVEF &amp;lt; 40% [HF with reduced ejection fraction (HFrEF), median age 72 years, 71% male], 21% had an LVEF 40\u201349% [HF with mid-range EF (HFmrEF), 77 years, 56% male], and 43% had an LVEF \u2265 50% [HF with preserved EF (HFpEF), 81 years, 44% male]. The primary outcome was death from any cause, and the secondary outcomes were cardiac death and re-hospitalization due to worsened HF after hospital discharge. There were high proportions of non-ischaemic cardiomyopathy (32%) in HFrEF patients, coronary artery disease (44%) in HFmrEF patients, and valvular disease (39%) in HFpEF patients. The frequencies of intravenous diuretic and natriuretic peptide administration during hospitalization were 66% and 30%, respectively. The median hospital stay for the overall population was 19 days, and the length of stay was &amp;gt;7 days for &amp;gt;90% of patients. In-hospital mortality was 7%, but was not different among the LVEF groups (HFrEF 7%, HFmrEF 6%, and HFpEF 8%). After a median follow-up of 19 months (range, 3\u201326 months), 192 (17%) of the 1156 patients who were discharged alive died, and 534 (46%) were re-hospitalized after hospital discharge. There were no significant differences in mortality after hospital discharge among the three LVEF groups (HFrEF 18%, HFmrEF 16%, and HFpEF 16%). There were no differences in cardiac death or re-hospitalization due to worsened HF after hospital discharge among the LVEF groups (cardiac death: HFrEF 8%, HFmrEF 7%, and HFpEF 7%; re-hospitalization due to worsened HF: HFrEF 19%, HFmrEF 16%, and HFpEF 17%). Multivariable-adjusted analyses showed that the HFmrEF and HFrEF groups, compared with the HFpEF group, were not associated with an increased risk for in-hospital death or death after hospital discharge. Non-cardiac causes of death and re-hospitalization after hospital discharge accounted for 35% and 38%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results revealed different clinical characteristics but similar mortality rates in the HFrEF, HFmrEF, and HFpEF groups. The most common cause of death and re-hospitalization after hospital discharge was HF, but non-cardiac causes also contributed to their prognosis. Integrated management approaches will be required for HF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12418","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T01:23:33Z","timestamp":1551662613000},"page":"475-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Clinical Characteristics of Hospitalized Heart Failure Patients with Preserved, Mid-Range, and Reduced Ejection Fractions in Japan"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0358-7196","authenticated-orcid":false,"given":"Tsuyoshi","family":"Shiga","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Haruta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University Yachiyo Medical Center , Yachiyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Yokohama Medical Center , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Kurihashi Hospital , Kuki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center of Sendai , Sendai ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Seirei Hamamatsu General Hospital , Hamamatsu ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Metropolitan Tama Medical Center , Fuchu ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Murasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tama-Hokubu Medical Center , Higashimurayama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, JCHO Sagamino Hospital , Sagamihara ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shinmatsudo Central General Hospital , Matsudo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 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University , 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]},{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen and DZHK (German Center for Cardiovascular Research) , G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Uetsuka","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics, Tokyo Women's Medical University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 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