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However, diagnosis of isolated CS may be difficult in some cases owing to the low sensitivity of myocardial biopsy. Herein, we describe the case of a patient with isolated CS, showing change from negative to positive fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) uptake results within 9 months. The patient showed rapid reduction in left ventricular systolic function with sustained ventricular tachycardia. The diagnosis of isolated CS is often under-recognized in clinical practice because it commonly requires the diagnosis of extracardiac disease in the absence of a positive endomyocardial biopsy. The Japanese Circulation Society recently published guidelines for CS diagnosis stating that isolated CS can be clinically diagnosed with positive 18F-FDG PET or 67Gallium result. In this case, serial follow-up 18F-FDG PET was useful for diagnosing isolated CS.<\/jats:p>","DOI":"10.1002\/ehf2.12472","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T07:25:26Z","timestamp":1562052326000},"page":"889-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Case of Isolated Cardiac Sarcoidosis Diagnosed by Newly Developed Abnormal Uptake During Serial Follow-Up Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography"],"prefix":"10.1093","volume":"6","author":[{"given":"Daichi","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Cardiology, Osaka Medical College , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka Medical College , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka Medical College , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaya","family":"Inuyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka Medical College , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka Medical College , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Miyamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka Medical College , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka Medical College , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Hoshiga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka Medical College , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"2026012115093563100_ehf212472-bib-0001","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1056\/NEJMra071714","article-title":"Sarcoidosis","volume":"357","author":"Iannuzzi","year":"2007","journal-title":"N Engl J Med"},{"key":"2026012115093563100_ehf212472-bib-0002","doi-asserted-by":"crossref","first-page":"546","DOI":"10.5114\/aoms.2011.24118","article-title":"Cardiac sarcoidosis: A comprehensive review","volume":"7","author":"Sekhri","year":"2011","journal-title":"Arch Med Sci"},{"key":"2026012115093563100_ehf212472-bib-0003","first-page":"89","article-title":"Diagnostic standard and guidelines for sarcoidosis","volume":"27","author":"Hiraga","year":"2007","journal-title":"Jpn J Sarcoidosis and Granulomatous Disorders"},{"key":"2026012115093563100_ehf212472-bib-0004","first-page":"19","article-title":"Organ Assessment Instrument Investigators TW. 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