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29% women) hospitalized for newly diagnosed or exacerbated HF were analysed. Associations between circulating levels of mid-regional pro-adrenomedullin (MR-proADM), copeptin, C-terminal pro-endothelin-1, N-terminal pro-brain natriuretic peptide (NT-proBNP), cystatin C, and all-cause mortality as well as risk of re-hospitalization due to cardiac causes were assessed using multivariable Cox regression models. A two-sided Bonferroni-corrected P-value of 0.05\/5 = 0.010 was considered statistically significant. All biomarkers were related to echocardiographic measurements of cardiac dimensions and function. A total of 57 patients died (median follow-up time, 17 months). In the multivariable-adjusted Cox regression analyses, all biomarkers, except C-terminal pro-endothelin-1, were significantly associated with increased mortality: NT-proBNP [hazard ratio (HR) 1.85, 95% confidence interval (CI) 1.17\u20132.17; P = 4.0 \u00d7 10\u22124], MR-proADM (HR 1.94, 95% CI 1.36\u20132.75; P = 2.2 \u00d7 10\u22124), copeptin (HR 1.70, 95% CI 1.22\u20132.36; P = 0.002), and cystatin C (HR 2.11, 95% CI 1.56\u20132.86; P = 1.0 \u00d7 10\u22126). A total of 90 patients were re-hospitalized (median time to re-hospitalization, 5 months). In multivariable Cox regression analyses, NT-proBNP was the only biomarker that showed significant association with risk of re-hospitalization due to cardiac causes (HR 1.43, 95% CI 1.10\u20131.87; P = 0.009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients hospitalized for HF, elevated plasma levels of NT-proBNP, MR-proADM, copeptin, and cystatin C are associated with higher mortality after discharge, whereas NT-proBNP is the only biomarker that predicts the risk of re-hospitalization due to cardiac causes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12486","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T11:15:52Z","timestamp":1563966952000},"page":"992-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cardiovascular Biomarkers Predict Post-Discharge Re-Hospitalization Risk and Mortality Among Swedish Heart Failure Patients"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-0510","authenticated-orcid":false,"given":"John","family":"Molvin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, Malm\u00f6 , Carl-Bertil Laurells gata 9, 214 28, Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-0158","authenticated-orcid":false,"given":"Amra","family":"Jujic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, Malm\u00f6 , Carl-Bertil Laurells gata 9, 214 28, Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-6892","authenticated-orcid":false,"given":"Erasmus","family":"Bachus","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Internal Medicine, Sk\u00e5ne University Hospital, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-9848","authenticated-orcid":false,"given":"Widet","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6633-0067","authenticated-orcid":false,"given":"Gordana","family":"Tasevska-Dinevska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, Malm\u00f6 , Carl-Bertil Laurells gata 9, 214 28, Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-484X","authenticated-orcid":false,"given":"Olle","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Internal Medicine, Sk\u00e5ne University Hospital, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-6327","authenticated-orcid":false,"given":"Artur","family":"Fedorowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, Malm\u00f6 , Carl-Bertil Laurells gata 9, 214 28, Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-5936","authenticated-orcid":false,"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6 , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, Malm\u00f6 , Carl-Bertil Laurells gata 9, 214 28, Malm\u00f6 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