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Our aim is to examine if 43 diabetes-related SNPs were associated with prevalent diastolic dysfunction assessed by echocardiography and incident CVD and\/or CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We genotyped 43 SNPs that previously reported genome-wide significant associations with Type 2 diabetes, in 1444 subjects from the population-based Malm\u00f6 Preventive Project-Re-examination Study (MPP-RES) (mean age 68 years; 29% women, 36% prevalent diabetes) (discovery cohort) and in 996 subjects from the VARA cohort (mean age 51 years, 52% women, 7% prevalent diabetes) (replication cohort). Multivariable logistic regression was assessed. Genetic variants that reached significant association with diastolic dysfunction in both cohorts were then analysed for association with incident CVD\/CHF in a larger sample of the MPP-RES cohort (3,407 cases and 11,776 controls, median follow up &amp;gt;30 years) using Cox regression analysis. A common variant at the HNF1B [major allele (T) coded, also the risk allele for diabetes] was the only SNP associated with increased risk of prevalent diastolic dysfunction in both the discovery [MPP-RES; odds ratio (OR) 1.21, P = 0.024), and the replication cohort (VARA; OR 1.38, P = 0.042]. Cox regression analysis showed that carriers of the T-allele of rs757210 had an increased risk of future CVD (HR 1.05, P = 0.042). No significant association was seen for incident CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The diabetes susceptibility locus HNF1B is associated with prevalent diastolic dysfunction in two independent Swedish cohorts as well as incident cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12573","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T15:51:21Z","timestamp":1576857081000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Diabetes-Associated Genetic Variant is Associated with Diastolic Dysfunction and Cardiovascular Disease"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-0510","authenticated-orcid":false,"given":"John","family":"Molvin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Clinical Research Center, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amra","family":"Jujic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Clinical Research Center, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Clinical Research Center, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Internal Medicine, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margret","family":"Leosdottir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Lindblad","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Department of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bledar","family":"Daka","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Department of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Bennet","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Clinical Research Center, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Center for primary health care research, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"R\u00e5stam","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Clinical Research Center, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriya","family":"Lyssenko","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center A\/S , Gentofte ,","place":["Denmark"]},{"name":"Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Center, Lund University \u00a0","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Clinical Research Center, Lund University , Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]},{"name":"Wallenberg Centre for Molecular Medicine, Lund University , Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"2026012115055341200_ehf212573-bib-0001","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11892-009-0014-9","article-title":"The failing diabetic heart: focus on diastolic left ventricular dysfunction","volume":"9","author":"van Heerebeek","year":"2009","journal-title":"Curr Diab 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