{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:08:58Z","timestamp":1788120538986,"version":"build-2803163510"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":2146,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Long-term outcome data of acute decompensated heart failure (HF) are scarce from India. The aim of the study was to collect in-hospital and long-term outcome data of HF patients admitted during 2001\u20132010 in a tertiary-care centre in South India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Consecutive patients admitted with first episode of decompensated HF were part of the registry. Data regarding diagnosis, risk factors, treatment, early (in-hospital), and late (5 and 10year) mortality outcomes were captured. During this period, 1502 patients were admitted with first episode of decompensated HF [37.7% of women, mean age of 51.1 (SD = 14.3) years]. Common causes were ischaemic heart disease (36.2%), rheumatic heart disease (34.3%), and cardiomyopathies (9.9%). HF with reduced ejection fraction (HFrEF) was present in 26.9% of patients, and 33.8% had atrial arrhythmias. Diabetes, hypertension, and renal dysfunction were prevalent in 27.4%, 28.6%, and 37.4%, respectively. Median duration of hospitalization was 6 days (interquartile range: 3\u201310), and 247 patients (16.4%) died during index admission. The total time at risk was 6248 person years, and 1051 patients died during the study period with a median survival time of 3.7 years. Overall mortality rate was 16.8 per 100 person years (95% CI: 15.8\u201317.9 per 100 person years). Older age [hazard ratio (HR) = 1.08, 95% CI: 1.02\u20131.14, P = 0.007], anaemia (HR = 1.34, 95% CI: 1.08\u20131.65, P = 0.007), renal dysfunction (HR = 1.38, 95% CI: 1.20\u20131.59, P &amp;lt; 0.001), HFpEF (HR = 0.61, 95% CI: 0.52\u20130.73, P &amp;lt; 0.001 against HFrEF), and the use of guideline-directed therapies (GDT; beta blockers: HR = 0.57, 95% CI: 0.49\u20130.66, P &amp;lt; 0.0001; and angiotensin converting enzyme inhibitor\/angiotensin receptor blocker: HR = 0.59, 95% CI: 0.51\u20130.69, P &amp;lt; 0.001) were important predictors of mortality. Patients with HF and mid-range EF also benefited from GDT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our cohort, ischaemic and rheumatic heart diseases were the leading contributors for HF. Anaemia, renal dysfunction, poor ejection fraction, and suboptimal prescriptions of GDT were the main predictors of long-term mortality. Both patients with HFrEF and mid-range EF benefited from GDT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12600","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T15:09:49Z","timestamp":1580742589000},"page":"467-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early and Long-Term Outcomes of Decompensated Heart Failure Patients in a Tertiary-Care Centre in India"],"prefix":"10.1093","volume":"7","author":[{"given":"Sanjay","family":"Ganapathi","sequence":"first","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum, 695011, Kerala ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panniyammakal","family":"Jeemon","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum, 695011, Kerala ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajasekharan","family":"Krishnasankar","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum, 695011, Kerala ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajamoni","family":"Kochumoni","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum, 695011, Kerala ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purushothaman","family":"Vineeth","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum, 695011, Kerala ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Kumar","family":"Mohanan Nair","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum, 695011, Kerala ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit Kumar","family":"Valaparambil","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum, 695011, Kerala ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivadasanpillai","family":"Harikrishnan","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology , Trivandrum, 695011, Kerala ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"2026012115045556000_ehf212600-bib-0001","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/ejhf.283","article-title":"Jeemon P and Trivandrum Heart Failure R. 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