{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:53:53Z","timestamp":1769086433309,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":2130,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to investigate prospectively the effect of sacubitril\/valsartan in advanced heart failure (HF) patients in waiting list for heart transplantation (HT) and the effect on physical frailty (PF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We treated 37 consecutive patients with advanced HF with sacubitril\/valsartan. Patients were followed up until HT, device implant, or last follow-up visit after 2 years of follow-up. At baseline, mean New York Heart Association (NYHA) class was 3.1 \u00b1 0.4, with 64.9% in NYHA III and 35.1% NYHA IIIB. Left ventricular ejection fraction was 23.5 \u00b1 5.8%, VO2 max was 10.3 \u00b1 2.3 mL\/kg\/min, cardiac index was 2.3 \u00b1 0.5 L\/min\/m2, and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) was 4943.0 \u00b1 5326.8 pg\/mL. After a mean follow-up of 17.1 \u00b1 4.4 months, no deaths were observed, but NYHA class improved significantly with 56.8% in NYHA II, 40.5% in NYHA III, and 2.7% in NYHA IIIB (P &amp;lt; 0.001). VO2 max and 6 min walk test (6MWT) increased, whereas pulmonary systolic blood pressure, E\/E\u2032, VE\/VCO2 slope, and NT-pro-BNP decreased. At right heart catheterization performed after 1 year of follow-up, cardiac index and pulmonary vascular resistance remained stable, while a decrease in systolic pulmonary artery pressure and pulmonary capillary wedge pressure is observed. Furosemide dosage decrease from 102.7 \u00b1 69.4 to 78.7 \u00b1 66.3 mg (P = 0.040). PF decreased from 3.35 \u00b1 1.0 at baseline to 1.57 \u00b1 1.3 at the end of follow-up (P &amp;lt; 0.001), with a reduction in all PF domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study showed a rapid improvement in PF in HT waiting list patients treated with sacubitril\/valsartan. The improvement in all PF domains was paralleled by VO2 and 6MWT increase and together with an NT-pro-BNP reduction constant over the follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12610","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T15:09:51Z","timestamp":1582124991000},"page":"757-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Sacubitril\/Valsartan in Patients Listed for Heart Transplantation: Effect on Physical Frailty"],"prefix":"10.1093","volume":"7","author":[{"given":"Francesco","family":"Cacciatore","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u2018Federico II\u2019 , 80131, Naples ,","place":["Italy"]},{"name":"Department of Cardiovascular Surgery and Transplant, Monaldi Hospital, Azienda dei Colli , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Amarelli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplant, Monaldi Hospital, Azienda dei Colli , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Maiello","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplant, Monaldi Hospital, Azienda dei Colli , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Mattucci","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplant, Monaldi Hospital, Azienda dei Colli , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Salerno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplant, Monaldi Hospital, Azienda dei Colli , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Di Maio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e0 degli Studi della Campania \u2018Luigi Vanvitelli\u2019, Monaldi Hospital , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and Transplant, Monaldi Hospital, Azienda dei Colli , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Curcio","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u2018Federico II\u2019 , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"Pirozzi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u2018Federico II\u2019 , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Mercurio","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u2018Federico II\u2019 , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuditta","family":"Benincasa","sequence":"additional","affiliation":[{"name":"University Department of Advanced Medical and Surgical Sciences, Clinical Department of Internal and Specialty Medicine (DAI), Universit\u00e0 degli Studi della Campania \u2018Luigi Vanvitelli\u2019 , 80138, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Golino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e0 degli Studi della Campania \u2018Luigi Vanvitelli\u2019, Monaldi Hospital , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Bonaduce","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u2018Federico II\u2019 , 80131, Naples ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Napoli","sequence":"additional","affiliation":[{"name":"University Department of Advanced Medical and Surgical Sciences, Clinical Department of Internal and Specialty Medicine (DAI), Universit\u00e0 degli Studi della Campania \u2018Luigi Vanvitelli\u2019 , 80138, Naples 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