{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:32:24Z","timestamp":1775025144687,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":2096,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Aptamer BC 007, a 15-mer single-strand DNA oligonucleotide (5\u2032-GGTTGGTGTGGTTGG-3\u2032), was developed to neutralize functional autoantibodies that bind to the extracellular domains of G protein-coupled receptors (GPCR-AAB), leading to the modulation of receptor-mediated signalling cascades that induce pathophysiological states. Among the GPCR-AAB, there are those directed against the \u03b21-adrenergic receptor (\u03b21-AAB) that are highly present in patients with dilated cardiomyopathy (DCM) and are increasingly accepted as disease drivers.<\/jats:p>\n                    <jats:p>Using Doberman Pinschers (DP) with DCM, which possess similarities with human DCM among these \u03b21-AAB positivity for that the disease-driving role in DP DCM was demonstrated, the safety of BC 007, efficacy for neutralizing \u03b21-AAB, and the DP's outcome were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Fourteen client-owned \u03b21-AAB-positive DP with electrocardiographically and echocardiographically indicated DCM were treated with BC 007. For controlling, two groups were created: 14 \u03b21-AAB-positive DP with DCM not treated with BC 007 (Control 1) and 14 DP with DCM closely matched to the BC 007-treated DP (Control 2), retrospectively selected from the institutional database of DP. After treatment, DP were monitored both echocardiographically, and for \u03b21-AAB, and survival curves were calculated. Based on clinical and laboratory examination, no adverse effects associated with BC 007 treatment were observed during the study. Forty-eight hours after treatment, the DP's blood was free of \u03b21-AAB, which led to a reduction or stabilization of left ventricular end-systolic volume (ESVI) during \u03b21-AAB free time in 10 of the treated DP. In one DP, where \u03b21-AAB returned after 3 months and ESVI worsened again, a second BC 007 treatment after 9 months again cleared the blood from \u03b21-AAB and improved the ESVI. Compared with the controls, DP treated with BC 007 showed a significantly longer survival time [572 days, interquartile range (IQR) 442\u2013840 days] vs. Control group 1 (266 days, IQR 97\u2013438 days; logrank: P = 0.009) and Control group 2 (229 days, IQR 174\u2013319 days; logrank: P = 0.012).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with BC 007 for \u03b21-AAB neutralization was safe, resulted in a long-lasting reduction of \u03b21-AAB combined with improved cardiac function and prolonged the survival of DP with DCM. Using a natural large animal model of DCM considered superior to small animal models of immunization-induced cardiomyopathy, combined with a study design comparable with clinical trials, we believe that our results provide the basis for optimism that treatment with BC 007 might also be effective in human patients with DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12628","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T20:43:48Z","timestamp":1585082628000},"page":"844-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Aptamer BC 007 for Treatment of Dilated Cardiomyopathy: Evaluation in Doberman Pinschers of Efficacy and Outcomes"],"prefix":"10.1093","volume":"7","author":[{"given":"Sabine","family":"Werner","sequence":"first","affiliation":[{"name":"Department of Cardiology, Clinic of Small Animal Medicine, Ludwig-Maximilians-University , Munich 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