{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:58:35Z","timestamp":1787162315680,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":2138,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Right heart catheterization (RHC) is indicated in all candidates for heart transplantation (HT). An acute vasodilator challenge is recommended for those with pulmonary hypertension (PH) to assess its reversibility. The effects of inhaled nitric oxide (iNO) on pulmonary and systemic haemodynamics have been reported only in small series. Our purpose was to describe the response to iNO in a larger population and its potential clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>From 210 RHC procedures performed between 2010 and 2019, vasodilator challenge with iNO was used in 108 patients, of which 66 had advanced heart failure undergoing assessment for HT (55\u00b111 years old; 74.2% male gender; 43.9% ischaemic cardiomyopathy; left ventricular ejection fraction 28.4 \u00b1 11,4%; and peak VO2 12.1 \u00b1 3.0 mL\/kg\/min). iNO was administered through a tight-fitting facial mask regardless of baseline pulmonary pressures. Clinical endpoints (all-cause mortality and acute right heart failure) were assessed according to baseline haemodynamic findings over the available follow-up period. There were no side effects from iNO administration. Typical response consisted of a reduction in pulmonary vascular resistance, consequent to an increase in left ventricular filling pressures, no significant change in mean pulmonary artery pressure (resulting in a lower mean transpulmonary gradient) and a mild increase in cardiac ouput. Pulmonary arterial compliance increased significantly, whereas systemic vascular resistance was only mildly affected. In five cases (7.6%), pulmonary vascular resistance increased paradoxically. All-cause mortality and post-HT right heart failure events were overall low and similar in patients without PH or reversible PH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vasodilator challenge with iNO is safe in advanced heart failure patients undergoing RHC prior to HT listing. It produces a reasonably predictable haemodynamic response, which occurs predominantly at the pulmonary circulation level. Clinical implications of iNO-induced reversibility may be relevant, but further systematic validation is warranted in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12639","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T09:51:10Z","timestamp":1581414670000},"page":"673-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Haemodynamic Effects and Potential Clinical Implications of Inhaled Nitric Oxide During Right Heart Catheterization in Heart Transplant Candidates"],"prefix":"10.1093","volume":"7","author":[{"given":"Christopher","family":"Strong","sequence":"first","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. Prof. Dr. Reinaldo dos Santos, Carnaxide, 2790-134 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Raposo","sequence":"additional","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. Prof. Dr. Reinaldo dos Santos, Carnaxide, 2790-134 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Castro","sequence":"additional","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. Prof. Dr. Reinaldo dos Santos, Carnaxide, 2790-134 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Madeira","sequence":"additional","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. Prof. Dr. Reinaldo dos Santos, Carnaxide, 2790-134 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Tralh\u00e3o","sequence":"additional","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. Prof. Dr. Reinaldo dos Santos, Carnaxide, 2790-134 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Ventosa","sequence":"additional","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. Prof. Dr. Reinaldo dos Santos, Carnaxide, 2790-134 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Rebocho","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Almeida","sequence":"additional","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. Prof. Dr. Reinaldo dos Santos, Carnaxide, 2790-134 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. Prof. Dr. Reinaldo dos Santos, Carnaxide, 2790-134 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pedro","family":"Neves","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Mendes","sequence":"additional","affiliation":[{"name":"Cardiology Deparment, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental , Av. 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