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We evaluated the diagnostic and prognostic utility of the novel urinary proteomic classifier HF1, compared with BNP, in HF. HF1 consists of 85 unique urinary peptide fragments thought, mainly, to reflect collagen turnover.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We performed urinary proteome analysis using capillary electrophoresis coupled with mass spectrometry in 829 participants. Of these, 622 had HF (504 had chronic HF and 118 acute HF) and 207 were controls (62 coronary heart disease patients without HF and 145 healthy controls). The area under the receiver operating characteristic (ROC) curve (AUC) using HF1 for the diagnosis of HF (cases vs. controls) was 0.94 (95% CI, 0.92\u20130.96). This compared with an AUC for BNP of 0.98 (95% CI, 0.97\u20130.99). Adding HF1 to BNP increased the AUC to 0.99 (0.98\u20130.99), P &amp;lt; 0.001, and led to a net reclassification improvement of 0.67 (95% CI, 0.54\u20130.77), P &amp;lt; 0.001. Among 433 HF patients followed up for a median of 989 days, we observed 186 deaths. HF1 had poorer predictive value to BNP for all-cause mortality and did not add prognostic information when combined with BNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The urinary proteomic classifier HF1 performed as well, diagnostically, as BNP and provided incremental diagnostic information when added to BNP. HF1 had less prognostic utility than BNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12708","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T05:02:18Z","timestamp":1588914138000},"page":"1595-1604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Novel Urinary Proteomic Classifier HF1 has Similar Diagnostic and Prognostic Utility to BNP in Heart Failure"],"prefix":"10.1093","volume":"7","author":[{"given":"Ross T.","family":"Campbell","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow , Glasgow, G12 8TA ,","place":["UK"]},{"name":"Queen Elizabeth University Hospital , Glasgow ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Jasilek","sequence":"additional","affiliation":[{"name":"Roberson Centre for Biostatistics, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Mischak","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow , Glasgow, G12 8TA ,","place":["UK"]},{"name":"Mosaiques Diagnostics GmbH , Hannover ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Nkuipou-Kenfack","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH , Hannover ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Latosinska","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH , Hannover ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul I.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow , Glasgow, G12 8TA ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colette E.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Queen Elizabeth University Hospital , Glasgow ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Cannon","sequence":"additional","affiliation":[{"name":"Harefield Hospital , Harefield, London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"McConnachie","sequence":"additional","affiliation":[{"name":"Roberson Centre for Biostatistics, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Delles","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow , Glasgow, G12 8TA ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.V.","family":"McMurray*","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow , Glasgow, G12 8TA ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"2026012115032258000_ehf212708-bib-0001","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). 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