{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T03:32:46Z","timestamp":1782012766383,"version":"3.54.5"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":2039,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of this study is to identify echocardiography predictors of clinical response and reverse left ventricular (LV) remodelling in patients with functional mitral regurgitation (FMR) treated with MitraClip.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and results<\/jats:title>\n                    <jats:p>We retrospectively analysed 86 high surgical risk patients with severe FMR; of those, 58 were implanted a MitraClip, and 28 received medical treatment and served as controls. At baseline and at 1-year follow-up, we performed clinical and echocardiography evaluation to assess global longitudinal strain (GLS) and myocardial work [global work index (GWI), global constructive work (GCW), global wasted work (GWW), global work efficiency (GWE)]. Mitral regurgitation was significantly reduced after MitraClip implantation (3.7 \u00b1 0.4 vs. 1.7 \u00b1 0.8, P &amp;lt; 0.001), and the procedure was associated with improvement in brain natriuretic peptide levels (980 \u00b1 1027 vs. 420 \u00b1 338 pg\/mL, P &amp;lt; 0.001), New York Heart Association class status (3.2 \u00b1 0.55 vs. 2.0 \u00b1 0.6, P &amp;lt; 0.001), 6-min walking test (233 \u00b1 154 vs. 286 \u00b1 114 m, P = 0.01) at follow-up and reduction of left ventricle end-systolic (LVESV) and left ventricle end-diastolic volumes (LVEDV) (152 \u00b1 68 vs. 136 \u00b1 43 mL, P = 0.004 &amp; 219 \u00b1 74 vs. 193 \u00b1 66 mL, P = 0.001, respectively). MitraClip procedure was associated with improvement of LV performance and significant increase of GWI (607 \u00b1 282 vs. 650 \u00b1 260 mmHg%, P = 0.045) and GCW (854 \u00b1 288 vs. 949 \u00b1 325 mmHg%, P &amp;lt; 0.001). Baseline ejection fraction (EF), GLS, GWI, GCW, and effective regurgitant orifice area were the variables that were associated with reduction of LVEDV 1 year after intervention (P &amp;lt; 0.05 for all) and baseline GCW of the LV was the only variable associated with reduction of LVESV (P = 0.002). Receiver operating characteristic curve analysis identified that a GLS cut-off value of \u22128.65% (AUC 0.815, P = 0.007) was associated with a 20% reduction of the LVEDV with a sensitivity and specificity of 72% and 70%, respectively, and that a GCW cut-off value of 846 mmHg% (AUC 0.759, P = 0.007) was associated with a 10% reduction of LVESV with sensitivity and specificity 79% and 74%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mitral valve repair with MitraClip has positive clinical and echocardiographic impact in patients with FMR 1 year after implantation. Preserved GLS and GCW values appear to be associated with LV reverse remodelling post intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12750","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T15:33:54Z","timestamp":1589988834000},"page":"1409-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["MitraClip and Left Ventricular Reverse Remodelling: A Strain Imaging Study"],"prefix":"10.1093","volume":"7","author":[{"given":"Konstantinos","family":"Papadopoulos","sequence":"first","affiliation":[{"name":"Transcatheter Heart Valves Department, HYGEIA Hospital , Athens ,","place":["Greece"]},{"name":"Echocardiography Laboratory, European Interbalkan Medical Center , Thessaloniki 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Hospital , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parissis","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, 2nd Cardiology Department, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Spargias","sequence":"additional","affiliation":[{"name":"Transcatheter Heart Valves Department, HYGEIA Hospital , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"2026012115033566000_ehf212750-bib-0001","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.echo.2018.05.010","article-title":"Long-term hemodynamic improvement after transcatheter mitral valve repair","volume":"31","author":"Lavall","year":"2018","journal-title":"J 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