{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:41:06Z","timestamp":1791319266266,"version":"4.3.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1996,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp & Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bayer Pharma AG, Berlin"},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of this retrospective analysis was to examine the association of left atrial (LA) strain (i.e. LA reservoir function) with left ventricular diastolic dysfunction (DD) in patients with heart failure with reduced and preserved left ventricular ejection fraction (LVEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed the baseline echocardiographic recordings of 300 patients in sinus rhythm from the SOCRATES-PRESERVED and SOCRATES-REDUCED studies. LA volume index was normal in 89 (29.7%), of whom 60.6% had an abnormal LA reservoir strain (i.e. \u226423%). In addition, the extent of LA strain impairment was significantly associated with the severity of DD according to the 2016 American Society of Echocardiography recommendations (DD grade I: LA strain 22.2 \u00b1 6.6, rate of abnormal LA strain 62.9%; DD grade II: LA strain 16.6 \u00b1 7.4, rate of abnormal LA strain 88.6%; DD grade III: LA strain 11.1 \u00b1 5.4%, rate of abnormal LA strain 95.7%; all P &amp;lt; 0.01). In line with these findings, LA strain had a good diagnostic performance to determine severe DD [area under the curve 0.83 (95% CI 0.77\u20130.88), cut-off 14.1%, sensitivity 80%, specificity 77.8%], which was significantly better than for LA volume index, LA total emptying fraction, and the mitral E\/e\u2032 ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this analysis suggest that LA strain could be a useful parameter in the evaluation of DD in patients with heart failure and sinus rhythm, irrespective of LVEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12820","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T03:50:45Z","timestamp":1593661845000},"page":"1956-1965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Left Atrial Strain as Sensitive Marker of Left Ventricular Diastolic Dysfunction in Heart Failure"],"prefix":"10.1093","volume":"7","author":[{"given":"Athanasios","family":"Frydas*","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine (Campus Virchow Klinikum) , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine (Campus Virchow Klinikum) , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health (BIH) , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Belyavskiy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine (Campus Virchow Klinikum) , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind-Kumar","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine (Campus Virchow Klinikum) , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), partner site Berlin , Berlin ,","place":["Germany"]},{"name":"Berlin Institute of Health (BIH) , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kropf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine (Campus Virchow Klinikum) , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Tadic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine (Campus Virchow Klinikum) , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Roessig","sequence":"additional","affiliation":[{"name":"Bayer AG , Wuppertal ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn S.P.","family":"Lam","sequence":"additional","affiliation":[{"name":"National Heart Centre \u00a0","place":["Singapore"]},{"name":"Department of Cardiology, University Medical Centre Groningen, University of Groningen , Groningen ,","place":["The Netherlands"]},{"name":"Duke-NUS Medical School \u00a0","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkert","family":"Pieske","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine (Campus Virchow Klinikum) , Augustenburger Platz 1, Berlin, 13353 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