{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:23Z","timestamp":1786977563831,"version":"build-2736575974"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1984,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with LMNA mutation-related heart disease are characterized by conduction abnormalities, ventricular tachyarrhythmias, and high risk of sudden cardiac death with mildly impaired systolic function, often without chamber dilation. Here, we presented three unrelated cases with LMNA mutation exhibited unusual cardiac phenotype of marked LV dilation, significant reduced ejection fraction with reginal wall akinesis, and transmural enhancement with a predilection of lateral wall on cardiovascular magnetic resonance (CMR). These three patients were found to have confirmed pathological LMNA mutations (c.1621C &amp;gt; T, p.R541C and c.1621G &amp;gt; A, p.R541H) at the same location (p.R541) in the tail region of lamin A\/C.<\/jats:p>","DOI":"10.1002\/ehf2.12822","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T20:41:47Z","timestamp":1594759307000},"page":"3179-3183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Case Series:\n                    <i>LMNA<\/i>\n                    -Related Dilated Cardiomyopathy Presents with Reginal Wall Akinesis and Transmural Late Gadolinium Enhancement"],"prefix":"10.1093","volume":"7","author":[{"given":"Shuai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Second Xiangya Hospital of Central South University , 139 Renmin Middle Road, Changsha, Hunan, 410011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoquan","family":"Peng*","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Second Xiangya Hospital of Central South University , 139 Renmin Middle Road, Changsha, Hunan, 410011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"2026012114070826500_ehf212822-bib-0001","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/heartjnl-2017-312338","article-title":"Lamin and the heart","volume":"104","author":"Captur","year":"2018","journal-title":"Heart"},{"key":"2026012114070826500_ehf212822-bib-0002","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.amjcard.2011.06.022","article-title":"Review and metaanalysis of the frequency of familial dilated cardiomyopathy","volume":"108","author":"Petretta","year":"2011","journal-title":"Am J Cardiol"},{"key":"2026012114070826500_ehf212822-bib-0003","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jacc.2011.08.078","article-title":"Risk factors for malignant ventricular arrhythmias in lamin a\/c mutation carriers a European cohort study","volume":"59","author":"van Rijsingen","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2026012114070826500_ehf212822-bib-0004","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"36","author":"Priori","year":"2015","journal-title":"Eur Heart J"},{"key":"2026012114070826500_ehf212822-bib-0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00109-004-0589-1","article-title":"Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A\/C mutations portend a high risk of sudden death?","volume":"83","author":"van Berlo","year":"2005","journal-title":"J Mol Med (Berl)"},{"key":"2026012114070826500_ehf212822-bib-0006","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.jacc.2016.08.058","article-title":"Long-term arrhythmic and nonarrhythmic outcomes of lamin A\/C mutation carriers","volume":"68","author":"Kumar","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2026012114070826500_ehf212822-bib-0007","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1532-429X-13-30","article-title":"Late gadolinium enhanced cardiovascular magnetic resonance of lamin A\/C gene mutation related dilated cardiomyopathy","volume":"13","author":"Holmstrom","year":"2011","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026012114070826500_ehf212822-bib-0008","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/jhg.2010.137","article-title":"A new c.1621 C &gt; G, p.R541G lamin A\/C mutation in a family with DCM and regional wall motion abnormalities (akinesis\/dyskinesis): genotype-phenotype correlation","volume":"56","author":"Malek","year":"2011","journal-title":"J Hum Genet"},{"key":"2026012114070826500_ehf212822-bib-0009","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.ijcard.2008.12.083","article-title":"Dilated cardiomyopathy with profound segmental wall motion abnormalities and ventricular arrhythmia caused by the R541C mutation in the LMNA gene","volume":"144","author":"Saj","year":"2010","journal-title":"Int J Cardiol"},{"key":"2026012114070826500_ehf212822-bib-0010","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1540-8167.2007.01017.x","article-title":"Cardiac arrest and left ventricular fibrosis in a Finnish family with the lamin A\/C mutation","volume":"19","author":"Hookana","year":"2008","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026012114070826500_ehf212822-bib-0011","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1388-9842(03)00149-1","article-title":"Apical left ventricular aneurysm without atrio-ventricular block due to a lamin A\/C gene mutation","volume":"5","author":"Forissier","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"2026012114070826500_ehf212822-bib-0012","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/jmg.2004.023283","article-title":"In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients","volume":"42","author":"Sylvius","year":"2005","journal-title":"J Med Genet"},{"key":"2026012114070826500_ehf212822-bib-0013","doi-asserted-by":"crossref","first-page":"132e","DOI":"10.1136\/jmg.40.12.e132","article-title":"Mutation analysis of the lamin A\/C gene (LMNA) among patients with different cardiomuscular phenotypes","volume":"40","author":"Vytopil","year":"2003","journal-title":"J Med Genet"},{"key":"2026012114070826500_ehf212822-bib-0014","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jcmg.2012.06.013","article-title":"CMR-verified interstitial myocardial fibrosis as a marker of subclinical cardiac involvement in LMNA mutation carriers","volume":"6","author":"Fontana","year":"2013","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fehf2.12822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.12822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.12822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/7\/5\/3179\/65807194\/eschf_7_5_3179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/7\/5\/3179\/65807194\/eschf_7_5_3179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:07:44Z","timestamp":1769022464000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/7\/5\/3179\/8372152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,14]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,7,14]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.12822","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,7,14]]},"assertion":[{"value":"2020-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}