{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:52:08Z","timestamp":1791237128860,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1990,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Das Deutsche Zentrum f\u00fcr Herz-Kreislauf-Forschung, DZHK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB834"],"award-info":[{"award-number":["SFB834"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB834"],"award-info":[{"award-number":["SFB834"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Systemic inflammatory response, identified by increased total leucocyte counts, was shown to be a strong predictor of mortality after transcatheter aortic valve implantation (TAVI). Yet the mechanisms of inflammation-associated poor outcome after TAVI are unclear. Therefore, the present study aimed at investigating individual inflammatory signatures and functional heterogeneity of circulating myeloid and T-lymphocyte subsets and their impact on 1 year survival in a single-centre cohort of patients with severe aortic stenosis undergoing TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>One hundred twenty-nine consecutive patients with severe symptomatic aortic stenosis admitted for transfemoral TAVI were included. Blood samples were obtained at baseline, immediately after, and 24 h and 3 days after TAVI, and these were analysed for inflammatory and cardiac biomarkers. Myeloid and T-lymphocyte subsets were measured using flow cytometry. The inflammatory parameters were first analysed as continuous variables; and in case of association with outcome and area under receiver operating characteristic (ROC) curve (AUC) \u2265 0.6, the values were dichotomized using optimal cut-off points. Several baseline inflammatory parameters, including high-sensitivity C-reactive protein (hsCRP; HR = 1.37, 95% CI: 1.15\u20131.63; P &amp;lt; 0.0001) and IL-6 (HR = 1.02, 95% CI: 1.01\u20131.03; P = 0.003), lower counts of Th2 (HR = 0.95, 95% CI: 0.91\u20130.99; P = 0.009), and increased percentages of Th17 cells (HR = 1.19, 95% CI: 1.02\u20131.38; P = 0.024) were associated with 12 month all-cause mortality. Among postprocedural parameters, only increased post-TAVI counts of non-classical monocytes immediately after TAVI were predictive of outcome (HR = 1.03, 95% CI: 1.01\u20131.05; P = 0.003). The occurrence of SIRS criteria within 48 h post-TAVI showed no significant association with 12 month mortality (HR = 0.57, 95% CI: 0.13\u20132.43, P = 0.45). In multivariate analysis of discrete or dichotomized clinical and inflammatory variables, the presence of diabetes mellitus (HR = 3.50; 95% CI: 1.42\u20138.62; P = 0.006), low left ventricular (LV) ejection fraction (HR = 3.16; 95% CI: 1.35\u20137.39; P = 0.008), increased baseline hsCRP (HR = 5.22; 95% CI: 2.09\u201313.01; P &amp;lt; 0.0001), and low baseline Th2 cell counts (HR = 8.83; 95% CI: 3.02\u201325.80) were significant predictors of death. The prognostic value of the linear prediction score calculated of these parameters was superior to the Society of Thoracic Surgeons score (AUC: 0.88; 95% CI: 0.78\u20130.99 vs. 0.75; 95% CI: 0.64\u20130.86, respectively; P = 0.036). Finally, when analysing LV remodelling outcomes, ROC curve analysis revealed that low numbers of Tregs (P = 0.017; AUC: 0.69) and increased Th17\/Treg ratio (P = 0.012; AUC: 0.70) were predictive of adverse remodelling after TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate an association of specific pre-existing inflammatory phenotypes with increased mortality and adverse LV remodelling after TAVI. Distinct monocyte and T-cell signatures might provide additive biomarkers to improve pre-procedural risk stratification in patients referred to TAVI for severe aortic stenosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12837","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T08:43:51Z","timestamp":1594197831000},"page":"2597-2610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Inflammatory Signatures are Associated with Increased Mortality After Transfemoral Transcatheter Aortic Valve Implantation"],"prefix":"10.1093","volume":"7","author":[{"given":"Jedrzej","family":"Hoffmann*","sequence":"first","affiliation":[{"name":"Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) , Partner site Rhine-Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mas-Peiro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) , Partner site Rhine-Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Berkowitsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Boeckling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) , Partner site Rhine-Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Rasper","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Pieszko","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nowa S\u00f3l Multidisciplinary Hospital , Nowa S\u00f3l ,","place":["Poland"]},{"name":"Faculty of Medicine and Health Sciences, University of Zielona G\u00f3ra , Zielona G\u00f3ra ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Hiczkiewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nowa S\u00f3l Multidisciplinary Hospital , Nowa S\u00f3l ,","place":["Poland"]},{"name":"Faculty of Medicine and Health Sciences, University of Zielona G\u00f3ra , Zielona G\u00f3ra ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Burchardt","sequence":"additional","affiliation":[{"name":"Biology of Lipid Disorders Department, Poznan University of Medical Sciences , Pozna\u0144 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Fichtlscherer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) , Partner site Rhine-Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas M.","family":"Zeiher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) , Partner site Rhine-Main ,","place":["Germany"]},{"name":"Cardiopulmonary Institute, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Dimmeler","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK) , Partner site Rhine-Main ,","place":["Germany"]},{"name":"Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"Cardiopulmonary Institute, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariuca Vasa","family":"Nicotera","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center of Internal Medicine, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) , Partner site Rhine-Main ,","place":["Germany"]},{"name":"Cardiopulmonary Institute, Goethe University Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"2026012114052858900_ehf212837-bib-0001","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1093\/eurheartj\/ehy465","article-title":"TAVI: from an experimental procedure to standard of care","volume":"39","author":"L\u00fcscher","year":"2018","journal-title":"Eur Heart J"},{"key":"2026012114052858900_ehf212837-bib-0002","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N Engl J Med"},{"key":"2026012114052858900_ehf212837-bib-0003","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients","volume":"376","author":"Reardon","year":"2017","journal-title":"N Engl J Med"},{"key":"2026012114052858900_ehf212837-bib-0004","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N Engl J Med"},{"key":"2026012114052858900_ehf212837-bib-0005","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N Engl J Med"},{"key":"2026012114052858900_ehf212837-bib-0006","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.4244\/EIJY14M06_05","article-title":"Occurrence and prognostic impact of systemic inflammatory response syndrome in transfemoral and transapical aortic valve implantation with balloon- and self-expandable valves","volume":"10","author":"Schwietz","year":"2015","journal-title":"EuroIntervention"},{"key":"2026012114052858900_ehf212837-bib-0007","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/eurheartj\/ehs002","article-title":"Systemic inflammatory response syndrome predicts increased mortality in patients after transcatheter aortic valve implantation","volume":"33","author":"Sinning","year":"2012","journal-title":"Eur Heart J"},{"key":"2026012114052858900_ehf212837-bib-0008","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/heartjnl-2014-307057","article-title":"Systemic inflammatory response syndrome after transcatheter or surgical aortic valve replacement","volume":"101","author":"Lindman","year":"2015","journal-title":"Heart"},{"key":"2026012114052858900_ehf212837-bib-0009","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1084\/jem.20170355","article-title":"The fate and lifespan of human monocyte subsets in steady state and systemic inflammation","volume":"214","author":"Patel","year":"2017","journal-title":"J Exp Med"},{"key":"2026012114052858900_ehf212837-bib-0010","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-immunol-042617-053119","article-title":"Nonclassical monocytes in health and disease","volume":"37","author":"Narasimhan","year":"2019","journal-title":"Annu Rev Immunol"},{"key":"2026012114052858900_ehf212837-bib-0011","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3389\/fimmu.2018.00883","article-title":"Emerging functions of regulatory T cells in tissue homeostasis","volume":"9","author":"Sharma","year":"2018","journal-title":"Front Immunol"},{"key":"2026012114052858900_ehf212837-bib-0012","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41423-019-0220-6","article-title":"Helper T cell differentiation","volume":"16","author":"Saravia","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"2026012114052858900_ehf212837-bib-0013","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/ATVBAHA.118.312002","article-title":"Novel features of monocytes and macrophages in cardiovascular biology and disease","volume":"39","author":"van der Vorst","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026012114052858900_ehf212837-bib-0014","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41591-018-0064-0","article-title":"Myeloid cell contributions to cardiovascular health and disease","volume":"24","author":"Nahrendorf","year":"2018","journal-title":"Nat Med"},{"key":"2026012114052858900_ehf212837-bib-0015","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007849","article-title":"Role of monocytes in heart failure and atrial fibrillation","volume":"7","author":"Shahid","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2026012114052858900_ehf212837-bib-0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183670","article-title":"Intermediate CD14++CD16+ monocytes decline after transcatheter aortic valve replacement and correlate with functional capacity and left ventricular systolic function","volume":"12","author":"Neuser","year":"2017","journal-title":"PLoS ONE"},{"key":"2026012114052858900_ehf212837-bib-0017","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12967-018-1702-5","article-title":"Machine-learned models using hematological inflammation markers in the prediction of short-term acute coronary syndrome outcomes","volume":"16","author":"Pieszko","year":"2018","journal-title":"J Transl Med"},{"key":"2026012114052858900_ehf212837-bib-0018","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9056402","article-title":"Predicting long-term mortality after acute coronary syndrome using machine learning techniques and hematological markers","volume":"2019","author":"Pieszko","year":"2019","journal-title":"Dis Markers"},{"key":"2026012114052858900_ehf212837-bib-0019","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00380-018-1244-z","article-title":"Predictors of atrial fibrillation early recurrence following cryoballoon ablation of pulmonary veins using statistical assessment and machine learning algorithms","volume":"34","author":"Budzianowski","year":"2019","journal-title":"Heart Vessels"},{"key":"2026012114052858900_ehf212837-bib-0020","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/eurheartj\/ehs255","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document","volume":"33","author":"Kappetein","year":"2012","journal-title":"Eur Heart J"},{"key":"2026012114052858900_ehf212837-bib-0021","doi-asserted-by":"crossref","DOI":"10.1145\/2939672.2939785","volume-title":"XGBoost: a scalable tree boosting system","author":"Chen","year":"2016"},{"key":"2026012114052858900_ehf212837-bib-0022","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.amjcard.2016.02.040","article-title":"Impact of diabetes mellitus on outcomes after transcatheter aortic valve implantation","volume":"117","author":"Abramowitz","year":"2016","journal-title":"Am J Cardiol"},{"key":"2026012114052858900_ehf212837-bib-0023","doi-asserted-by":"crossref","first-page":"13886","DOI":"10.1038\/srep13886","article-title":"Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous","volume":"5","author":"Mukherjee","year":"2015","journal-title":"Sci Rep"},{"key":"2026012114052858900_ehf212837-bib-0024","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41419-018-0327-1","article-title":"The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence","volume":"9","author":"Ong","year":"2018","journal-title":"Cell Death Dis"},{"key":"2026012114052858900_ehf212837-bib-0025","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1161\/ATVBAHA.114.304650","article-title":"Nonclassical patrolling monocyte function in the vasculature","volume":"35","author":"Thomas","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026012114052858900_ehf212837-bib-0026","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0039-1700871","article-title":"High-Content Immunophenotyping and Hierarchical Clustering Reveal Sources of Heterogeneity and New Surface Markers of Human Blood Monocyte Subsets","volume":"120","author":"Hoffmann","year":"2020","journal-title":"Thromb Haemost"},{"key":"2026012114052858900_ehf212837-bib-0027","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking","volume":"168","author":"Dufour","year":"2002","journal-title":"J Immunol"},{"key":"2026012114052858900_ehf212837-bib-0028","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1189\/jlb.5A0717-302","article-title":"A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines","volume":"102","author":"Zhao","year":"2017","journal-title":"J Leukoc Biol"},{"key":"2026012114052858900_ehf212837-bib-0029","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1161\/01.CIR.98.22.2370","article-title":"Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina","volume":"98","author":"Liuzzo","year":"1998","journal-title":"Circulation"},{"key":"2026012114052858900_ehf212837-bib-0030","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1161\/CIRCULATIONAHA.113.007101","article-title":"CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload","volume":"129","author":"Laroumanie","year":"2014","journal-title":"Circulation"},{"key":"2026012114052858900_ehf212837-bib-0031","doi-asserted-by":"crossref","first-page":"E2420","DOI":"10.1073\/pnas.1621047114","article-title":"Myocardial aging as a T-cell-mediated phenomenon","volume":"114","author":"Ramos","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012114052858900_ehf212837-bib-0032","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1189\/jlb.1213633","article-title":"Th17 cells and Tregs: unlikely allies","volume":"95","author":"Chen","year":"2014","journal-title":"J Leukoc Biol"},{"key":"2026012114052858900_ehf212837-bib-0033","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.immuni.2008.05.007","article-title":"Molecular antagonism and plasticity of regulatory and inflammatory T cell programs","volume":"29","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"2026012114052858900_ehf212837-bib-0034","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature14452","article-title":"Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation","volume":"523","author":"Gagliani","year":"2015","journal-title":"Nature"},{"key":"2026012114052858900_ehf212837-bib-0035","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.celrep.2017.10.090","article-title":"Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance","volume":"21","author":"Wei","year":"2017","journal-title":"Cell Rep"},{"key":"2026012114052858900_ehf212837-bib-0036","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2011.03.018","article-title":"Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation","volume":"34","author":"Chaudhry","year":"2011","journal-title":"Immunity"},{"key":"2026012114052858900_ehf212837-bib-0037","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.108.188243","article-title":"IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR","volume":"104","author":"Krishnamurthy","year":"2009","journal-title":"Circ Res"},{"key":"2026012114052858900_ehf212837-bib-0038","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1084\/jem.20171274","article-title":"Cardiac macrophages promote diastolic dysfunction","volume":"215","author":"Hulsmans","year":"2018","journal-title":"J Exp Med"},{"key":"2026012114052858900_ehf212837-bib-0039","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1161\/CIRCULATIONAHA.117.032839","article-title":"Myocardial scar and mortality in severe aortic stenosis","volume":"138","author":"Musa","year":"2018","journal-title":"Circulation"},{"key":"2026012114052858900_ehf212837-bib-0040","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3389\/fimmu.2018.01048","article-title":"Foxp3+ T regulatory cells: still many unanswered questions\u2014a perspective after 20 years of study","volume":"9","author":"Shevach","year":"2018","journal-title":"Front Immunol"},{"key":"2026012114052858900_ehf212837-bib-0041","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/CIRCRESAHA.118.313129","article-title":"Anticytokine agents: targeting interleukin signaling pathways for the treatment of atherothrombosis","volume":"124","author":"Ridker","year":"2019","journal-title":"Circ Res"},{"key":"2026012114052858900_ehf212837-bib-0042","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","article-title":"Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure","volume":"139","author":"Everett","year":"2019","journal-title":"Circulation"},{"key":"2026012114052858900_ehf212837-bib-0043","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/annrheumdis-2019-eular.1671","article-title":"Efficacy and safety of e6011, an anti-fractalkine monoclonal antibody, in Mtx-Ir patients with rheumatoid arthritis","volume":"78","author":"Tanaka","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"2026012114052858900_ehf212837-bib-0044","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/acel.12430","article-title":"CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study","volume":"15","author":"Spyridopoulos","year":"2016","journal-title":"Aging Cell"},{"key":"2026012114052858900_ehf212837-bib-0045","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"Fuster","year":"2017","journal-title":"Science"},{"key":"2026012114052858900_ehf212837-bib-0046","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2018-01-829937","article-title":"Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A","volume":"132","author":"Buscarlet","year":"2018","journal-title":"Blood"},{"key":"2026012114052858900_ehf212837-bib-0047","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/eurheartj\/ehz591","article-title":"Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoingvtranscatheter aortic valve implantation","volume":"41","author":"Mas-Peiro","year":"2020","journal-title":"Eur Heart J"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fehf2.12837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.12837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.12837","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/7\/5\/2597\/65807489\/eschf_7_5_2597.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/7\/5\/2597\/65807489\/eschf_7_5_2597.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:05:59Z","timestamp":1769022359000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/7\/5\/2597\/8372051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,8]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,7,8]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.12837","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,7,8]]},"assertion":[{"value":"2020-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}