{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:08:51Z","timestamp":1769123331431,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":2003,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hennepin Health Services"},{"name":"Oxford-Emergent Tuberculosis Consortium"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203135"],"award-info":[{"award-number":["203135"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104-803"],"award-info":[{"award-number":["104-803"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["095780"],"award-info":[{"award-number":["095780"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009342","name":"Aeras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"European & Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["IP.07.32080.002"],"award-info":[{"award-number":["IP.07.32080.002"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203135"],"award-info":[{"award-number":["203135"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104\u2010803"],"award-info":[{"award-number":["104\u2010803"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["095780"],"award-info":[{"award-number":["095780"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bank of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009342","name":"Aeras Global Tuberculosis Vaccine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["IP.07.32080.002"],"award-info":[{"award-number":["IP.07.32080.002"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Efforts to improve access to antiretroviral therapy (ART) have shifted morbidity and mortality among persons living with HIV (PLWH) from AIDS to non-communicable diseases, such as cardiovascular disease (CVD). However, contemporary data on CVD among PLWH in sub-Saharan Africa in the current ART era are lacking. The aim of this study was to assess the burden of cardiac stress among PLWH in South Africa via measurement of N-terminal prohormone of brain natriuretic peptide (NT-proBNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>NT-proBNP was measured at baseline in 224 PLWH enrolled in a sub-study of a tuberculosis vaccine trial in Khayelitsha township near Cape Town, South Africa. Thresholds were applied at the assay's limit of detection (\u2265137 pg\/mL) and a level indicative of symptomatic heart failure in the acute setting (&amp;gt;300 pg\/mL).<\/jats:p>\n                    <jats:p>Mean (SD) age of participants was 39 (6) years, 86% were female, and 19% were hypertensive. Mean (SD) duration of HIV diagnosis was 8.3 (3.9) years and CD4 + count was 673 (267) with 79% prescribed ART for a duration of 5.6 (2.7) years. Thirty-one percent of participants had NT-proBNP &amp;gt; 300 pg\/mL. Elevated vs. undetectable NT-proBNP level was associated with older age (P = 0.04), no ART (P = 0.03), and higher plasma tumour necrosis factor-\u03b1 (P = 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among South African PLWH largely free of known CVD and on ART with high CD4 + counts and few comorbidities, we observed a high proportion with elevated NT-proBNP levels, suggesting the burden of cardiac stress in this population may be high. This observation underscores the need for more in-depth research, including the current effect of HIV on heart failure risk among a growing ART-treated population in sub-Saharan Africa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12849","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T19:58:30Z","timestamp":1593115110000},"page":"3246-3251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Elevated N-Terminal Prohormone of Brain Natriuretic Peptide Among Persons Living with HIV in a South African Peri-Urban Township"],"prefix":"10.1093","volume":"7","author":[{"given":"Tess E.","family":"Peterson*","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota , Minneapolis, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason V.","family":"Baker","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Hennepin Healthcare Research Institute , Minneapolis, MN ,","place":["USA"]},{"name":"Department of Medicine, University of Minnesota , Minneapolis, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lye-Yeng","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oregon Health Sciences University , Portland, OR ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Rupert","sequence":"additional","affiliation":[{"name":"Leidos Biomedical Research Inc, Frederick National Laboratory for Cancer Research , Frederick, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ntobeko A. B.","family":"Ntusi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanif","family":"Esmail","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"MRC Clinical Trials Unit, University College London , London ,","place":["UK"]},{"name":"Institute for Global Health, University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Infectious Disease, Imperial College London , London ,","place":["UK"]},{"name":"Francis Crick Institute , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irini","family":"Sereti","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Meintjes","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mpiko","family":"Ntsekhe","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Thienemann","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Medicine, University Hospital Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"2026012114063432400_ehf212849-bib-0001","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/QAI.0000000000000825","article-title":"Long-term mortality in HIV-infected individuals 50 years or older: a nationwide, population-based cohort study","volume":"71","author":"Legarth","year":"2016","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026012114063432400_ehf212849-bib-0002","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1093\/infdis\/jiw275","article-title":"Immunologic biomarkers, morbidity, and mortality in treated HIV infection","volume":"214","author":"Hunt","year":"2016","journal-title":"J Infect Dis"},{"key":"2026012114063432400_ehf212849-bib-0003","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/CIRCULATIONAHA.117.033369","article-title":"Global burden of cardiovascular disease in people living with HIV: systematic review and meta-analysis","volume":"138","author":"Shah","year":"2018","journal-title":"Circulation"},{"key":"2026012114063432400_ehf212849-bib-0004","author":"State of the Epidemic Report","year":"2018"},{"key":"2026012114063432400_ehf212849-bib-0005","volume-title":"South African National HIV Prevalence, Incidence and Behaviour Survey, 2012","author":"Shisana","year":"2014"},{"key":"2026012114063432400_ehf212849-bib-0006","first-page":"2006","volume-title":"Revised Burden of Disease Estimates for the Comparative Risk Factor Assessment","author":"Norman"},{"key":"2026012114063432400_ehf212849-bib-0007","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0140-6736(08)60417-1","article-title":"Spectrum of heart disease and risk factors in a black urban population in South Africa (the Heart of Soweto Study): a cohort study","volume":"371","author":"Sliwa","year":"2008","journal-title":"Lancet"},{"key":"2026012114063432400_ehf212849-bib-0008","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1586\/14779072.7.2.169","article-title":"Epidemiology of heart failure in sub-Saharan Africa","volume":"7","author":"Ntusi","year":"2009","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"2026012114063432400_ehf212849-bib-0009","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1001\/archinternmed.2012.3310","article-title":"The causes, treatment, and outcome of acute heart failure in 1006 Africans from 9 countries","volume":"172","author":"Damasceno","year":"2012","journal-title":"Arch Intern Med"},{"key":"2026012114063432400_ehf212849-bib-0010","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1093\/eurheartj\/eht388","article-title":"HIV and the heart: the impact of antiretroviral therapy: a global perspective","volume":"34","author":"Thienemann","year":"2013","journal-title":"Eur Heart J"},{"key":"2026012114063432400_ehf212849-bib-0011","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ijcard.2014.08.007","article-title":"Obesity and natriuretic peptides, BNP and NT-proBNP: mechanisms and diagnostic implications for heart failure","volume":"176","author":"Madamanchi","year":"2014","journal-title":"Int J Cardiol"},{"key":"2026012114063432400_ehf212849-bib-0012","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjcard.2007.11.012","article-title":"Biology of the natriuretic peptides","volume":"101","author":"Martinez-Rumayor","year":"2008","journal-title":"Am J Cardiol"},{"key":"2026012114063432400_ehf212849-bib-0013","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.jacc.2004.06.015","article-title":"Primary results of the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT). A multicenter study of B-type natriuretic peptide levels, emergency department decision making, and outcomes in patients presenting with shortness of breath","volume":"44","author":"Maisel","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2026012114063432400_ehf212849-bib-0014","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1463-1326.2006.00607.x","article-title":"Diagnostic utility of brain-natriuretic peptide for left ventricular diastolic dysfunction in asymptomatic type 2 diabetic patients","volume":"9","author":"Shimabukuro","year":"2007","journal-title":"Diabetes Obes Metab"},{"key":"2026012114063432400_ehf212849-bib-0015","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0002-9343(01)00841-5","article-title":"Utility of B-natriuretic peptide levels in identifying patients with left ventricular systolic or diastolic dysfunction","volume":"111","author":"Krishnaswamy","year":"2001","journal-title":"Am J Med"},{"key":"2026012114063432400_ehf212849-bib-0016","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/hc0502.103010","article-title":"Utility of B-natriuretic peptide in detecting diastolic dysfunction: comparison with Doppler velocity recordings","volume":"105","author":"Lubien","year":"2002","journal-title":"Circulation"},{"key":"2026012114063432400_ehf212849-bib-0017","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ejhf.1381","article-title":"Prediction of incident heart failure by serum amino-terminal pro-B-type natriuretic peptide level in a community-based cohort","volume":"21","author":"Campbell","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2026012114063432400_ehf212849-bib-0018","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijcard.2016.11.110","article-title":"Biomarkers for characterization of heart failure\u2013distinction of heart failure with preserved and reduced ejection fraction","volume":"227","author":"Sinning","year":"2017","journal-title":"Int J Cardiol"},{"key":"2026012114063432400_ehf212849-bib-0019","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/CIRCRESAHA.117.311312","article-title":"Cardiovascular event prediction by machine learning: the multi-ethnic study of atherosclerosis","volume":"121","author":"Ambale-Venkatesh","year":"2017","journal-title":"Circulation Res"},{"key":"2026012114063432400_ehf212849-bib-0020","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/CIRCULATIONAHA.115.017298","article-title":"N-terminal pro-brain natriuretic peptide and heart failure risk among individuals with and without obesity: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"133","author":"Ndumele","year":"2016","journal-title":"Circulation"},{"key":"2026012114063432400_ehf212849-bib-0021","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1136\/heartjnl-2015-307782","article-title":"Prognostic value of NT-proBNP in heart failure with preserved versus reduced EF","volume":"101","author":"Kang","year":"2015","journal-title":"Heart"},{"key":"2026012114063432400_ehf212849-bib-0022","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ejhf.140","article-title":"Prognostic value of N-terminal pro C-type natriuretic peptide in heart failure patients with preserved and reduced ejection fraction","volume":"16","author":"Lok","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"2026012114063432400_ehf212849-bib-0023","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1373\/clinchem.2013.203638","article-title":"Troponin T and N-terminal pro\u2013B-type natriuretic peptide: a biomarker approach to predict heart failure risk\u2014the atherosclerosis risk in communities study","volume":"59","author":"Nambi","year":"2013","journal-title":"Clin Chem"},{"key":"2026012114063432400_ehf212849-bib-0024","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/eurheartj\/eht066","article-title":"Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND","volume":"34","author":"Brouwers","year":"2013","journal-title":"Eur Heart J"},{"key":"2026012114063432400_ehf212849-bib-0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00392-009-0108-z","article-title":"Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction","volume":"99","author":"Luers","year":"2010","journal-title":"Clin Res Cardiol"},{"key":"2026012114063432400_ehf212849-bib-0026","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1161\/CIRCULATIONAHA.109.884866","article-title":"B-type natriuretic peptides and cardiovascular risk: systematic review and meta-analysis of 40 prospective studies","volume":"120","author":"Di Angelantonio","year":"2009","journal-title":"Circulation"},{"key":"2026012114063432400_ehf212849-bib-0027","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10741-014-9446-7","article-title":"Prediction of clinical outcomes using B-type natriuretic peptides in the general population: a systematic review","volume":"19","author":"Don-Wauchope","year":"2014","journal-title":"Heart Failure Rev"},{"key":"2026012114063432400_ehf212849-bib-0028","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.amjcard.2007.11.016","article-title":"Amino-terminal pro-B-type natriuretic peptide testing to assist the diagnostic evaluation of heart failure in symptomatic primary care patients","volume":"101","author":"Hildebrandt","year":"2008","journal-title":"Am J Cardiol"},{"key":"2026012114063432400_ehf212849-bib-0029","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/eurheartj\/ehn309","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)","volume":"29","author":"Dickstein","year":"2008","journal-title":"Eur Heart J."},{"key":"2026012114063432400_ehf212849-bib-0030","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.jacc.2007.02.037","article-title":"Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure","volume":"49","author":"Fonarow","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2026012114063432400_ehf212849-bib-0031","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S2213-2600(15)00037-5","article-title":"Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial","volume":"3","author":"Ndiaye","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2026012114063432400_ehf212849-bib-0032","volume-title":"Western Cape Province Department of Health, City of Cape Town Department of Health, University of Cape Town, Centre for Infectious Disease Epidemiology and Research","author":"Medicines Sans Frontieres"},{"key":"2026012114063432400_ehf212849-bib-0033","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026012114063432400_ehf212849-bib-0034","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/jamacardio.2017.0264","article-title":"Association between HIV infection and the risk of heart failure with reduced ejection fraction and preserved ejection fraction in the antiretroviral therapy era: results from the Veterans Aging Cohort Study","volume":"2","author":"Freiberg","year":"2017","journal-title":"JAMA Cardiol"},{"key":"2026012114063432400_ehf212849-bib-0035","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012241","article-title":"HIV infection and incidence of cardiovascular diseases: an analysis of a large healthcare database","volume":"8","author":"Alonso","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2026012114063432400_ehf212849-bib-0036","first-page":"737","article-title":"Risk of heart failure with human immunodeficiency virus in the absence of prior diagnosis of coronary heart disease","volume":"171","author":"Butt","year":"2011","journal-title":"Arch of Int Med"},{"key":"2026012114063432400_ehf212849-bib-0037","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/eurheartj\/ehr398","article-title":"Contribution of the human immunodeficiency virus\/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort","volume":"33","author":"Sliwa","year":"2011","journal-title":"Eur Heart J"},{"key":"2026012114063432400_ehf212849-bib-0038","volume-title":"Ending AIDS: Progress towards the 90\u201390-90 targets","author":"Joint United Nations Programme on HIV\/AIDS (UNAIDS)"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fehf2.12849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.12849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.12849","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/7\/5\/3246\/65807620\/eschf_7_5_3246.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/7\/5\/3246\/65807620\/eschf_7_5_3246.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:07:07Z","timestamp":1769022427000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/7\/5\/3246\/8372118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,25]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,6,25]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.12849","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,6,25]]},"assertion":[{"value":"2020-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}