{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:14:34Z","timestamp":1769116474375,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1918,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"AGEL"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The improved clinical response in patients with left bundle branch block (LBBB) over LBBB-free patients treated with cardiac resynchronization therapy with a defibrillator (CRT-D) is commonly attributed to an LBBB abnormality. We aimed to find an alternative explanation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed an immediate effect of selecting the LBBB group of patients in a cohort of 63 non-ischaemic cardiomyopathy (non-ICM) and 83 ischaemic cardiomyopathy (ICM) patients treated with CRT-D; 75% of non-ICM and 51% of ICM patients had an LBBB abnormality on the electrocardiogram, with a significant difference (P = 0.0032 by \u03c72). As a result of this difference, the proportion of non-ICM patients increased from 43% in the primary cohort to 53% in LBBB selection and decreased to 28% in non-LBBB group. By nonparametric survival analysis, the hazard ratio in non-ICM patients in the LBBB selection decreased from 0.48 (P = 0.0488) to 0.36 (P = 0.0251) and increased in the non-LBBB group to 0.75 (P = 0.6496). Any comparison of LBBB and non-LBBB groups must compare sets with a significantly altered proportion of patients of different aetiologies. Most publications on LBBB patients are erroneous because they compare LBBB with non-LBBB groups, not taking into account that the groups have been substantially changed by the selection process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The declared outcome of the LBBB groups reflects inevitably the survival outcome of their non-ICM patients and not the intended outcome of patients with LBBB. CRT-D in patients with different aetiologies of cardiomyopathy calls for separate evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12893","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T05:21:30Z","timestamp":1600406490000},"page":"3667-3675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Why is the Clinical Response to Cardiac Resynchronization Better in LBBB Patients?"],"prefix":"10.1093","volume":"7","author":[{"given":"Ji\u0159\u00ed","family":"Kvasni\u010dka","sequence":"first","affiliation":[{"name":"Department of Invasive Arrhythmology, Cardiac Center AGEL, AGEL AS , Pardubice ,","place":["Czech Republic"]},{"name":"Cardiology Department, Internal Medicine Clinic, Pardubice Hospital , Pardubice ,","place":["Czech Republic"]},{"name":"1st Department of Internal Medicine - Cardioangiology, Charles University Medical Faculty and Teaching Hospital , Hradec Kr\u00e1lov\u00e9 ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale\u0161","family":"Havl\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Department of Invasive Arrhythmology, Cardiac Center AGEL, AGEL AS , Pardubice ,","place":["Czech Republic"]},{"name":"Cardiology Department, Internal Medicine Clinic, Pardubice Hospital , Pardubice ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"B\u011blohl\u00e1vek","sequence":"additional","affiliation":[{"name":"Department of Invasive Arrhythmology, Cardiac Center AGEL, AGEL AS , Pardubice ,","place":["Czech Republic"]},{"name":"Cardiology Department, Internal Medicine Clinic, Pardubice Hospital , Pardubice ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Ve\u010de\u0159a","sequence":"additional","affiliation":[{"name":"Department of Invasive 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