{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:19:47Z","timestamp":1769084387623,"version":"3.49.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1932,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Coronavirus disease 2019 (COVID-19) patients with cardiac injury have an increased risk of mortality. It remains to be determined the mechanism of cardiac injury and the identification of specific conditions that affect the heart during COVID-19. We present the case of a 76-year-old woman with COVID-19 pneumonia that developed a takotsubo syndrome (TTS). Although the patient presented normal left ventricular ejection fraction and normal levels of troponin on admission, after 16 days in intensive care unit due to respiratory distress, she suddenly developed cardiogenic shock. Shock occurred few hours after a spontaneous breathing trial through her tracheostomy. Bed-side echocardiographic revealed apical ballooning promptly supporting the diagnosis of TTS. She was successfully treated with deep sedation and low dosage of epinephrine. The relevance of this case is that TTS can occur in the late phase of COVID-19. Awareness of late TTS and bed-side echocardiographic evaluation can lead to prompt identification and treatment.<\/jats:p>","DOI":"10.1002\/ehf2.12912","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T13:08:53Z","timestamp":1599224933000},"page":"4297-4300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Takotsubo Syndrome as a Complication in a Critically Ill COVID-19 Patient"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-7767","authenticated-orcid":false,"given":"Maurizio","family":"Bottiroli","sequence":"first","affiliation":[{"name":"Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"De Caria","sequence":"additional","affiliation":[{"name":"Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriana","family":"Belli","sequence":"additional","affiliation":[{"name":"Cardiology, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Calini","sequence":"additional","affiliation":[{"name":"Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Andreoni","sequence":"additional","affiliation":[{"name":"Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Siragusa","sequence":"additional","affiliation":[{"name":"Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]},{"name":"Medical School, Milan-Bicocca University , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Moreo","sequence":"additional","affiliation":[{"name":"Cardiology, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1676-5257","authenticated-orcid":false,"given":"Enrico","family":"Ammirati","sequence":"additional","affiliation":[{"name":"Cardiology, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Mondino","sequence":"additional","affiliation":[{"name":"Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano Niguarda , Milan ,","place":["Italy"]},{"name":"Medical School, Milan-Bicocca University , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"2026012114080994200_ehf212912-bib-0001","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/jamacardio.2020.1017","article-title":"Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19)","volume":"27","author":"Guo","year":"2020","journal-title":"JAMA Cardiol. 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