{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:18:21Z","timestamp":1769120301611,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1954,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016304","name":"Medtronic plc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Response to cardiac resynchronization therapy (CRT) is known to be associated with a number of clinical characteristics, including QRS duration and morphology, gender, height, and the aetiology of heart failure (HF). We assessed the relation of gender and baseline characteristics with QRS duration and Kansas City Cardiomyopathy Questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>AdaptResponse is a global randomized trial. The trial enrolled CRT-indicated patients with New York Heart Association classes II\u2013IV HF, left bundle branch block (QRS \u2265 140 ms in men, \u2265130 ms in women), and baseline PR interval \u2264200 ms. In total, 3620 patients were randomized, including 1569 women (43.3%) approaching the actual proportion of women in the HF population. Women were older and more often New York Heart Association class III or IV than men (55.6% vs. 48.7%), had less frequent ischaemic cardiomyopathy (21.2% vs. 39.5%), and had a 5.1 ms shorter QRS duration than men. Women were more often depressed (18.5% vs. 9.7%), had a significantly lower Kansas City Cardiomyopathy Questionnaire score, and had differences in medication prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AdaptResponse is the largest randomized CRT trial and enrolled more women than any other landmark CRT trial. Women differed from men with regard to baseline characteristics and quality of life. Whether these differences translate into clinical outcome differences will be examined further in the AdaptResponse trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12914","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T09:40:58Z","timestamp":1597311658000},"page":"2972-2982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Differences in Clinical Characteristics and Reported Quality of Life of Men and Women Undergoing Cardiac Resynchronization Therapy"],"prefix":"10.1093","volume":"7","author":[{"given":"Bruce L.","family":"Wilkoff","sequence":"first","affiliation":[{"name":"Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Birnie","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of South Carolina , Charleston, SC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad S.","family":"Hersi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Medtronic Bakken Research Center , Maastricht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Gerritse","sequence":"additional","affiliation":[{"name":"Medtronic Bakken Research Center , Maastricht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Kusano","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Leclercq","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Rennes , Rennes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Mullens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium and Hasselt University , Hasselt ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"School of Medicine, National and Kapodistrian University of Athens , Athens ,","place":["Greece"]},{"name":"School of Medicine, University of Cyprus , Nicosia ,","place":["Cyprus"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"2026012114062867900_ehf212914-bib-0001","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"2026012114062867900_ehf212914-bib-0002","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0003","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrcardio.2014.67","article-title":"Strategies to improve cardiac resynchronization therapy","volume":"11","author":"Vernooy","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0004","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jacc.2014.06.1162","article-title":"Sex-specific mortality risk by QRS morphology and duration in patients receiving CRT: results from the NCDR","volume":"64","author":"Zusterzeel","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0005","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/jamainternmed.2014.2717","article-title":"Cardiac resynchronization therapy in women: US Food and Drug Administration meta-analysis of patient-level data","volume":"174","author":"Zusterzeel","year":"2014","journal-title":"JAMA Intern Med"},{"key":"2026012114062867900_ehf212914-bib-0006","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.hfc.2018.08.011","article-title":"Implantable cardioverter-defibrillators and cardiac resynchronization therapy in women","volume":"15","author":"Ignaszewski","year":"2019","journal-title":"Heart Fail Clin"},{"key":"2026012114062867900_ehf212914-bib-0007","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jacc.2010.06.061","article-title":"Cardiac resynchronization therapy is more effective in women than in men: the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) trial","volume":"57","author":"Arshad","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0008","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1540-8159.2010.02909.x","article-title":"Female gender is associated with a better outcome after cardiac resynchronization therapy","volume":"34","author":"Leyva","year":"2011","journal-title":"Pacing Clin Electrophysiol"},{"key":"2026012114062867900_ehf212914-bib-0009","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ejhf.1133","article-title":"The interaction of sex, height, and QRS duration on the effects of cardiac resynchronization therapy on morbidity and mortality: an individual-patient data meta-analysis","volume":"20","author":"Linde","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026012114062867900_ehf212914-bib-0010","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1161\/CIRCULATIONAHA.110.956011","article-title":"Bundle-branch block morphology and other predictors of outcome after cardiac resynchronization therapy in Medicare patients","volume":"122","author":"Bilchick","year":"2010","journal-title":"Circulation"},{"key":"2026012114062867900_ehf212914-bib-0011","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1161\/CIRCULATIONAHA.110.014324","article-title":"Predictors of response to cardiac resynchronization therapy in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT)","volume":"124","author":"Goldenberg","year":"2011","journal-title":"Circulation"},{"key":"2026012114062867900_ehf212914-bib-0012","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ahj.2011.11.014","article-title":"Effect of QRS morphology on clinical event reduction with cardiac resynchronization therapy: meta-analysis of randomized controlled trials","volume":"163","author":"Sipahi","year":"2012","journal-title":"Am Heart J"},{"key":"2026012114062867900_ehf212914-bib-0013","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.amjcard.2010.11.010","article-title":"Defining left bundle branch block in the era of cardiac resynchronization therapy","volume":"107","author":"Strauss","year":"2011","journal-title":"Am J Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0014","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jacep.2017.02.021","article-title":"Sex-specific response to cardiac resynchronization therapy: effect of left ventricular size and QRS duration in left bundle branch block","volume":"3","author":"Varma","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"2026012114062867900_ehf212914-bib-0015","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N Engl J Med"},{"key":"2026012114062867900_ehf212914-bib-0016","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"2026012114062867900_ehf212914-bib-0017","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejheart.2005.01.010","article-title":"Baseline characteristics of patients recruited into the CARE-HF study","volume":"7","author":"Cleland","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"2026012114062867900_ehf212914-bib-0018","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1751-7133.2008.07613.x","article-title":"Baseline characteristics of patients randomized in the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) study","volume":"14","author":"Linde","year":"2008","journal-title":"Congest Heart Fail"},{"key":"2026012114062867900_ehf212914-bib-0019","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"2026012114062867900_ehf212914-bib-0020","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1009540","article-title":"Cardiac-resynchronization therapy for mild-to-moderate heart failure","volume":"363","author":"Tang","year":"2010","journal-title":"N Engl J Med"},{"key":"2026012114062867900_ehf212914-bib-0021","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ahj.2012.02.007","article-title":"A novel algorithm for individualized cardiac resynchronization therapy: rationale and design of the adaptive cardiac resynchronization therapy trial","volume":"163","author":"Krum","year":"2012","journal-title":"Am Heart J"},{"key":"2026012114062867900_ehf212914-bib-0022","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.hrthm.2012.07.009","article-title":"Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy: results of the adaptive CRT trial","volume":"9","author":"Martin","year":"2012","journal-title":"Heart Rhythm"},{"key":"2026012114062867900_ehf212914-bib-0023","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.hrthm.2013.07.007","article-title":"Clinical outcomes with synchronized left ventricular pacing: analysis of the adaptive CRT trial","volume":"10","author":"Birnie","year":"2013","journal-title":"Heart Rhythm"},{"key":"2026012114062867900_ehf212914-bib-0024","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/europace\/eut107","article-title":"Clinical response with adaptive CRT algorithm compared with CRT with echocardiography-optimized atrioventricular delay: a retrospective analysis of multicentre trials","volume":"15","author":"Singh","year":"2013","journal-title":"Europace"},{"key":"2026012114062867900_ehf212914-bib-0025","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/ejhf.895","article-title":"Rationale and design of the AdaptResponse trial: a prospective randomized study of cardiac resynchronization therapy with preferential adaptive left ventricular-only pacing","volume":"19","author":"Filippatos","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2026012114062867900_ehf212914-bib-0026","doi-asserted-by":"crossref","first-page":"216","DOI":"10.14797\/mdcj-13-4-216","article-title":"Heart failure in women","volume":"13","author":"Bozkurt","year":"2017","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"2026012114062867900_ehf212914-bib-0027","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"2026012114062867900_ehf212914-bib-0028","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ejhf.1142","article-title":"CRT Survey II: a European Society of Cardiology survey of cardiac resynchronisation therapy in 11 088 patients\u2014who is doing what to whom and how?","volume":"20","author":"Dickstein","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026012114062867900_ehf212914-bib-0029","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1001\/jamacardio.2018.2559","article-title":"Enrollment of older patients, women, and racial and ethnic minorities in contemporary heart failure clinical trials: a systematic review","volume":"3","author":"Tahhan","year":"2018","journal-title":"JAMA Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0030","doi-asserted-by":"crossref","DOI":"10.1136\/hrt.2006.099523","article-title":"Management of patients with heart failure in clinical practice: differences between men and women","volume":"94","author":"Lenzen","year":"2008","journal-title":"Heart"},{"key":"2026012114062867900_ehf212914-bib-0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2261-3-1","article-title":"Management of congestive heart failure: a gender gap may still exist. Observations from a contemporary cohort","volume":"3","author":"Burstein","year":"2003","journal-title":"BMC Cardiovasc Disord"},{"key":"2026012114062867900_ehf212914-bib-0032","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jacc.2018.09.081","article-title":"Differential impact of heart failure with reduced ejection fraction on men and women","volume":"73","author":"Dewan","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0033","article-title":"Sex differences in optimal atrioventricular delay in patients receiving cardiac resynchronization therapy","author":"Kloosterman","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0034","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002013","article-title":"Sex differences in long-term outcomes with cardiac resynchronization therapy in mild heart failure patients with left bundle branch block","volume":"4","author":"Biton","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"2026012114062867900_ehf212914-bib-0035","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2008.08.027","article-title":"Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms","volume":"52","author":"Linde","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0036","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jacc.2007.08.058","article-title":"Risk stratification for primary implantation of a cardioverter-defibrillator in patients with ischemic left ventricular dysfunction","volume":"51","author":"Goldenberg","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026012114062867900_ehf212914-bib-0037","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCULATIONAHA.112.097709","article-title":"Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: results from the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) study","volume":"126","author":"Gold","year":"2012","journal-title":"Circulation"},{"key":"2026012114062867900_ehf212914-bib-0038","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1161\/CIRCOUTCOMES.114.001548","article-title":"Cardiac resynchronization therapy in women versus men: observational comparative effectiveness study from the National Cardiovascular Data Registry","volume":"8","author":"Zusterzeel","year":"2015","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2026012114062867900_ehf212914-bib-0039","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1093\/eurheartj\/eht290","article-title":"An individual patient meta-analysis of five randomized trials assessing the effects of cardiac resynchronization therapy on morbidity and mortality in patients with symptomatic heart failure","volume":"34","author":"Cleland","year":"2013","journal-title":"Eur Heart J"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fehf2.12914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.12914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.12914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/7\/5\/2972\/65806925\/eschf_7_5_2972.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/7\/5\/2972\/65806925\/eschf_7_5_2972.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:07:04Z","timestamp":1769022424000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/7\/5\/2972\/8372113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,8,13]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.12914","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,8,13]]},"assertion":[{"value":"2020-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}